Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Technical Services Manager Whey and Ingredients
$88K - $105K *
Analyze and optimize whey and ingredient processes to enhance efficiency, quality, and yield. Lead projects, ensure compliance with safety standards, and provide technical support to improve operation...
2 weeks ago
$215K - $240K *
Shape the future of commercial operations by leading strategy, workflows, and data integration. Collaborate with senior leaders to enhance brand performance and drive operational excellence across cro...
2 weeks ago
Regional Sales Manager III - South East
$160K - $250K *
Engage with diverse stakeholders to drive sales growth in FWA, M2M, and IoT solutions. Develop new customer relationships while enhancing existing accounts, leveraging a robust channel ecosystem to ma...
2 weeks ago
Client Onboarding Manager (Finance & Accounting Outsourcing)
$101K - $192K *
Oversee the onboarding of new clients for outsourced accounting services, managing relationships and leading teams to ensure timely financial reporting and exceptional service delivery while driving p...
2 weeks ago
Forward Deployed Process Consultant- R37
$113K - $226K *
Lead the charge in optimizing healthcare processes by bridging strategy and execution. Collaborate with teams to enhance coding workflows, drive change management, and ensure alignment with strategic...
2 weeks ago
Enterprise Account Executive, Carolinas
$290K - $305K *
Champion enterprise sales initiatives in the Carolinas and Tennessee. Drive strategic growth by engaging large organizations, building partnerships, and leveraging advanced sales techniques; you'll ex...
Reposted 2 weeks ago
Director, Contracts Management
$190K - $210K *
Transform the contract management landscape for large-scale data center projects. Oversee RFx processes, negotiate contracts, and ensure compliance while collaborating with cross-functional teams to m...
2 weeks ago
Global Marketing Manager, Atellica Assays – Infectious Disease (Remote)
$137K - $189K *
Drive the global strategy for Atellica Infectious Disease assays, connecting customer needs with product development. Lead cross-functional teams to ensure successful launches and sustained market gro...
2 weeks ago
Vice President, Value Partnerships DX
$207K - $284K *
Elevate strategic partnerships in the healthcare diagnostics sector, driving innovative solutions and collaboration across teams. Lead high-impact initiatives that align customer needs with Siemens He...
2 weeks ago
Hemostasis Sales Specialist - Las Vegas Region
$99K - $136K *
Pioneer strategic growth in Hemostasis solutions, driving revenue and market share expansion through complex sales engagements and executive relationships across healthcare systems and laboratories...
2 weeks ago
Hemostasis Sales Specialist - East Texas Region
$99K - $136K *
Join a dynamic team as a strategic growth architect, driving revenue and market share expansion in the Hemostasis portfolio. Leverage your expertise in complex healthcare sales to influence decision-m...
2 weeks ago
Director, Commercial Business Operations
$141K - $194K *
Transform commercial operations by leading cross-functional initiatives, driving clarity, execution, and impactful outcomes. Collaborate with diverse teams to continuously enhance processes and integr...
Reposted 2 weeks ago
Hemostasis Sales Specialist - Northern California Region
$99K - $136K *
Elevate your career by driving strategic growth in Hemostasis solutions. As a key player, you'll lead complex sales cycles, cultivate executive relationships, and deliver measurable value across healt...
2 weeks ago
Hemostasis Sales Specialist - Atlanta / Charlotte Region
$99K - $136K *
Champion strategic growth in Hemostasis solutions by leading complex sales cycles, cultivating executive relationships, and driving market share expansion through innovative automation and informatics...
2 weeks ago
Field Product Manager - Eastern U.S. (Territory-Based Role)
$116K - $159K *
Accelerate progress at the forefront of sales strategy and team development. Collaborate with cross-functional teams to drive revenue growth, enhance customer engagement, and ensure optimal sales proc...
2 weeks ago
MR Clinical Education Specialist (Central, Northeast or Midwest)
$89K - $122K *
Drive impactful onsite and virtual education for Siemens MRI systems, ensuring exceptional customer training experiences. Collaborate with teams to develop tailored training materials and programs tha...
2 weeks ago
Cardiovascular Vice President - Central Zone
$159K - $218K *
Advance your career by leading a dynamic sales team to drive growth in cardiovascular imaging. Shape strategies, enhance customer satisfaction, and achieve financial goals while making a significant i...
2 weeks ago
CT (Computerized Tomography) Installation Engineer - Remote/Travel/Field
$74K - $102K *
Advance your career by providing expert installation support for CT systems, ensuring quality and timely project completion while collaborating with vendors and stakeholders. Travel required for custo...
2 weeks ago
Enterprise Marketing Manager, Cardiovascular
$141K - $194K *
Drive impactful marketing strategies for cardiovascular solutions, enhancing visibility and demand through multi-channel campaigns. Collaborate with cross-functional teams to create compelling content...
2 weeks ago
Director of Sales Enablement, Digital and Automation
$158K - $217K *
Empower sales teams by driving productivity and effectiveness through strategic enablement initiatives, fostering collaboration across departments, and translating business priorities into impactful f...
2 weeks ago
Senior Director Enterprise Services - North Carolina
$159K - $218K *
Drive strategic growth by leading national accounts and fostering executive relationships. Collaborate across teams to enhance customer engagement and market share, while executing comprehensive accou...
2 weeks ago
CT (Computerized Tomography) Installation Engineer - Remote/Travel/Field
$74K - $102K *
Drive the charge in expert CT installations, ensuring quality and timely project completion while providing top-tier support and troubleshooting for field service teams and vendors...
2 weeks ago
Director of Operations, ES, North Carolina
$143K - $196K *
Elevate healthcare delivery by leading strategic partnerships and enhancing operational performance. Collaborate across teams to drive exceptional customer engagement and ensure alignment with clinica...
2 weeks ago
Project Manager - Construction & Medical Imaging Installs - Washington DC - Field / Travel
$107K - $147K *
Empower your career by managing complex imaging equipment projects, fostering key relationships, and ensuring timely delivery and installation across healthcare environments. Drive success through eff...
2 weeks ago
Director of Operations, ES - Tampa, FL
$143K - $196K *
Elevate healthcare delivery by leading strategic partnerships and optimizing operations within Oncology service lines. Drive performance through exceptional customer engagement and collaboration acros...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.