Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$170K - $185K *

Drive customer success by leading clinical initiatives and fostering executive relationships. Leverage clinical expertise and data-driven strategies to enhance operational effectiveness and ensure lon...

Today

  •   11 - 15 years exp.  •   Healthcare

$225K - $280K *

Engage as a key technical resource for channel sales, driving success with global partners. Leverage your expertise in networking solutions to enhance relationships, deliver impactful demos, and suppo...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive growth by managing end-to-end sales cycles in the Energy sector, enhancing customer relationships, and executing strategies to exceed targets while collaborating with cross-functional teams for...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$68K - $105K *

Help us lead enterprise-wide incident responses and internal investigations into misconduct, ensuring compliance and effective fraud detection while collaborating across departments to uphold organiza...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Inspire a high-performing team as you lead engineering projects, mentor talent, and drive technical excellence. Collaborate across disciplines to enhance design quality and operational efficiency whil...

Today

  •   11 - 15 years exp.  •   Technical Services

$95K - $115K *

Drive project success by managing engineering and administrative functions, ensuring effective communication among teams, and adhering to safety and compliance standards throughout the construction pr...

Today

  •   8 - 10 years exp.  •   Real Estate & Construction

$75K - $108K *

Unlock potential by managing diverse research projects, coordinating operations, and supporting data analysis. Collaborate with interdisciplinary teams to drive impactful educational initiatives and e...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Lead and empower a high-performance team while driving strategic initiatives and sales growth in North America. Collaborate with senior executives to enhance customer alignment and develop innovative...

Reposted today

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$120K - $150K *

Transform the delivery landscape by leading cross-functional initiatives, mentoring analysts, and driving strategic solutions across business units and external partners. Engage deeply in project exec...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $125K *

Unlock potential by joining our team as an EP Mapping Specialist, where you'll provide clinical and technical support for cardiac mapping solutions, collaborate with healthcare professionals, and driv...

Philadelphia, PARemote

Today

  •   5 - 7 years exp.  •   Healthcare

$120K - $125K *

Transform healthcare by providing clinical and technical support for cardiac mapping solutions. Collaborate with clinicians and engineers to enhance patient outcomes and drive sales growth in a dynami...

Today

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Empower your career by leading IT audits and SOX programs, managing a skilled team, and enhancing audit quality through data analytics and automation while collaborating with business leaders to stren...

Today

  •   8 - 10 years exp.  •   Hospitality & Recreation

$240K - $379K *

Champion innovative government programs by leading multidisciplinary teams to deploy cutting-edge NVIDIA solutions. Collaborate with diverse stakeholders to ensure successful execution and drive impac...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$116K - $257K *

Join us to lead strategic initiatives in Retail Banking, driving growth and transformation through client partnerships and innovative solutions. Collaborate with experts to optimize capabilities and s...

Today

  •   11 - 15 years exp.  •   Enterprise Technology

$145K - $175K *

Lead the engineering and implementation of advanced cloud security solutions across multi-cloud environments. Collaborate with cross-functional teams to enhance security posture, automate processes, a...

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $125K *

Elevate your career by partnering with cross-functional teams to enhance regulatory reporting accuracy and compliance. Utilize your analytical skills to drive strategic initiatives and ensure adherenc...

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in delivering exceptional patient care as a Staff Pharmacist, collaborating with healthcare teams to optimize medication therapy and enhance pharmacy operations while ensuring complian...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$83K - $104K *

Lead the charge in managing complex client programs, driving operational excellence and strategic direction while fostering strong stakeholder relationships and ensuring exceptional service delivery...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$85K - $100K *

Optimize patient care by conducting examinations, formulating treatment plans, and collaborating with healthcare teams to enhance patient outcomes across various clinical settings...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Unlock innovation by designing scalable system architectures for rail solutions. Collaborate with cross-functional teams to ensure robust, future-ready systems that enhance mobility and safety, drivin...

Today

  •   Less than 5 years exp.  •   Energy & Utilities

$85K - $100K *

Join a team that's dedicated to enhancing the health of frail elderly participants through comprehensive assessments and care management, collaborating with specialists to ensure optimal health outcom...

Today

  •   Less than 5 years exp.  •   Healthcare

$188K - $265K *

Accelerate progress at the forefront of AI infrastructure by leading technical direction, ensuring platform architecture meets company ambitions, and fostering collaboration across engineering teams f...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$124K - $158K *

Transform patient care by leading the pharmacy team, ensuring compliance, and delivering exceptional pharmacy services. Support the continuous improvement of health outcomes while fostering a culture...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$124K - $158K *

Champion patient care and pharmacy excellence while leading a dedicated team. Drive operations and compliance in a fast-paced environment, supporting health improvements through accurate dispensing, c...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$81K - $95K *

Shape the future of payments by supporting sales teams with tailored presentations and analytics. Collaborate with C-Level executives to foster new business relationships and enhance client engagement...

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.