Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Program Manager, Global Strategic Accounts
$130K - $160K *
Drive program success by coordinating cross-functional teams, managing reporting, and optimizing engagement strategies for a global enterprise account, ensuring alignment with client goals and employe...
2 weeks ago
Channel Development, Lead Retention
$115K - $158K *
Drive strategies to enhance customer engagement and retention for pharmacy services. Collaborate with cross-functional teams to optimize member experiences, increase auto-refill adoption, and boost pr...
Reposted 6 days ago
Director, Pricing & Business Analysis
$120K - $145K *
Join a team that's redefining pricing strategies and business analysis. As a key member, you'll develop competitive pricing models, analyze risks, and collaborate with finance and business development...
3 weeks ago
Vice President of Social, National
$120K *
Empower the national brand by leading social media strategy, driving engagement, and fostering partnerships. Oversee content creation and analytics to enhance audience reach and conversion across dive...
3 weeks ago
Senior Product Manager - Commercial Suite & Payments
$120K - $145K *
Join a team that's redefining payment solutions! Drive strategic product management, leading innovative card offerings and fostering high-performing teams while shaping market-leading strategies and e...
Reposted 2 weeks ago
$140K - $180K *
Accelerate progress at the intersection of Treasury and Accounting, managing cash forecasting, customer collections, and disbursements. Collaborate with cross-functional teams to ensure financial inte...
1 week ago
Managing Director, Assessment & Human Capital
$170K - $230K *
Drive strategic growth and innovation in AI-enabled assessment and workforce solutions. Lead high-impact projects, foster collaboration, and enhance AIR's national leadership in education and workforc...
Yesterday
Director, Strategic Business Development
$150K - $180K *
Drive sustained growth as a key commercial leader by executing innovative revenue strategies, generating new client opportunities, and expanding market presence in the evolving data center and AI infr...
Reposted 3 weeks ago
1723 - Senior Manager, Strategic Sourcing- D&C
$97K - $190K *
Champion strategic sourcing in Design & Construction, leading procurement initiatives to optimize value and drive cost savings. Collaborate with stakeholders to enhance supplier relationships and ensu...
1 week ago
$100K - $120K *
Empower Public Safety agencies by driving sales and fostering relationships across a multi-state territory. Manage the sales cycle through consultative partnerships, ensuring pipeline growth and reven...
Reposted 3 weeks ago
Remote Quality Improvement Data Analyst
$70K - $106K *
Transform operational data into actionable insights while collaborating with cross-functional teams to support business decisions and enhance efficiency. Leverage analytical skills to drive performanc...
Reposted 3 days ago
Senior Manager, Underwriting Unit Lead
$67K - $182K *
Lead the charge in driving operational excellence and strategic direction for a high-performing underwriting team, ensuring quality Medicare underwriting services that support profitable growth and bu...
2 weeks ago
Regional Manager Payor Accounts - Midwest
$140K - $185K *
Accelerate your career by executing regional payor strategies to secure coverage and reimbursement for innovative Surgical Glaucoma products. Collaborate with cross-functional teams and build relation...
Reposted 2 days ago
Director, Enterprise Operations, FP&A
$120K - $150K *
Transform supply chain financial management by leading cost analysis, budgeting, and strategic initiatives. Empower a cross-functional team to drive operational excellence and continuous improvement a...
1 week ago
$70K - $140K *
Lead the charge in enhancing our Partner ecosystem by managing relationships and driving growth initiatives. Oversee onboarding, operations, and support for System Integrators while implementing autom...
Reposted 3 weeks ago
Technical Project Manager / Scrum Master
$90K - $140K *
Join a dynamic team to lead complex data management projects, blending Agile methodologies with technical expertise. Drive collaboration across healthcare analytics, ensuring successful delivery and s...
3 days ago
Senior Director, Quality Assurance (Remote)
$225K - $275K *
Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...
Reposted 3 days ago
Senior Director, Regulatory Affairs
$211K - $281K *
Champion regulatory excellence by leading U.S. FDA engagement and strategy for product development, ensuring timely approvals and compliance while driving cross-functional collaboration and organizati...
3 weeks ago
Clinical Operations and Analytics Consultant
$82K - $128K *
Shape data-driven strategies by developing and automating analytics solutions. Collaborate with cross-functional teams to enhance reporting capabilities and optimize operational performance in a dynam...
1 week ago
Account Executive - Clinical Documentation Solutions Remote
$100K - $125K *
Drive new business in healthcare technology by engaging with hospitals and ambulatory organizations. Leverage AI-enabled solutions and clinical documentation services to meet client needs and achieve...
1 week ago
Senior Director of Strategic Partnerships
$150K - $180K *
Advance your career by leading strategic partnerships, optimizing relationships, and driving revenue growth. Collaborate across teams to enhance product capabilities and market reach while managing a...
1 week ago
$128K - $145K *
Support the full life cycle of vendor contracts, from negotiation to execution. Collaborate with stakeholders to manage legal risks and ensure compliance in a fast-paced environment, focusing on healt...
2 days ago
AVP, Procurement Center of Excellence
$184K - $254K *
Shape the future of Procurement by leading enterprise capabilities that enhance performance, streamline processes, and drive technology integration, ensuring measurable value and strategic alignment a...
2 days ago
Senior Director, CEO Communications
$203K - $290K *
Empower impactful narratives as you architect and lead a global CEO communications strategy, translating complex tech innovations into compelling stories that resonate across media and digital platfor...
2 weeks ago
$125K - $144K *
Optimize our data platform by owning end-to-end data engineering projects, leveraging AI coding agents, and ensuring data quality. Collaborate with cross-functional teams to deliver reliable, maintain...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.