Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$127K - $203K *
Join the charge in shaping technical solutions by transforming stakeholder needs into actionable requirements, fostering collaboration within teams, and ensuring project success throughout the product...
Reposted 3 weeks ago
Director, Business Systems & Solution Architecture (D365 F&O)
$155K - $170K *
Lead the charge in shaping enterprise business solutions through hands-on architecture and delivery in Microsoft Dynamics 365 Finance & Operations, focusing on integration, process optimization, and o...
Reposted 1 week ago
Manager of Insurance Verification & Authorizations
$101K - $146K *
Elevate the insurance verification and authorization process by managing staff, developing strategies, and ensuring excellent service delivery while resolving complex patient financial needs in a coll...
3 weeks ago
Director, Technical Program Management, Ad Tech
$162K - $228K *
Transform the Ad Tech landscape by leading cross-functional teams to ensure seamless delivery and execution of complex technology portfolios, driving strategic initiatives and fostering collaboration...
1 week ago
Director/Senior Director, CMC Quality Operations
$200K - $290K *
Contribute to the advancement of cancer therapies by managing analytical development and quality control operations, ensuring compliance with regulatory standards, and collaborating across teams to en...
Yesterday
Senior Director, Quality Control (QC) Program Implementation Lead
$216K - $243K *
Pioneer advancements in vaccine research and development, driving global immunization efforts. Collaborate across teams to ensure compliance and effective delivery of safe vaccines, enhancing public h...
6 days ago
$120K - $145K *
Transform complex data systems by designing and implementing scalable solutions that enhance analytics and drive business intelligence in a collaborative, Agile environment focused on healthcare compl...
4 days ago
GovCon Technology Senior Manager (with Deltek Costpoint experience)
$133K - $262K *
Engage with clients and lead projects through all phases to achieve project goals while enhancing methodologies and tools tailored for the government contracting industry. Drive business development a...
Reposted 3 weeks ago
Associate Director, Analytical Development
$185K - $215K *
Take ownership of analytical development initiatives, ensuring compliance, accuracy, and high-quality documentation for multiple projects. Collaborate closely with internal teams and external partners...
Reposted yesterday
$103K - $123K *
Drive growth by managing a sales territory, building relationships, and generating premium. Leverage existing partnerships while prospecting new agencies to achieve targets and expand market presence...
1 week ago
$110K - $130K *
Grow your career by driving sales and developing strategic relationships within major sectors across the AMER region, ensuring revenue maximization and effective execution of account strategies...
4 weeks ago
$85K - $95K *
Transform processes and drive accountability by leading cross-functional projects. Manage initiatives from scoping to completion while maintaining clear communication across teams and ensuring stakeho...
4 weeks ago
$162K - $243K *
Shape the future of clinical research by leading cross-functional teams to optimize project delivery, ensuring quality and compliance while managing resources and budgets effectively across global cli...
1 week ago
National Account Director, Enterprise Access
$240K - $269K *
Advance your career by leading national account strategies in oncology, fostering relationships with health plans and PBMs. Drive coverage, reimbursement, and adoption initiatives while collaborating...
1 week ago
$150K - $180K *
Transform power generation strategies by leading innovative solutions and optimizing energy contracts. Drive collaboration across teams to enhance project management and accelerate market readiness fo...
6 days ago
$95K - $153K *
Analyze and optimize enterprise-scale data architectures, pipelines, and integrations. Provide technical leadership in SQL, ETL/ELT development, cloud solutions, and data governance while supporting a...
Reposted yesterday
$150K - $180K *
Champion integrated marketing strategies to drive growth, enhance brand awareness, and support sales initiatives. Lead cross-functional teams in executing customer-centric programs that generate deman...
2 weeks ago
Sr. Manager, HRIS & Operations
$120K - $150K *
Drive HRIS excellence by optimizing technologies and core processes, enhancing compliance, and delivering impactful solutions that elevate operational efficiency and employee experience across the org...
4 weeks ago
Senior Director, Global GMP/GDP Audit and Predictive Compliance Intelligence
$198K - $268K *
Lead the global GMP/GDP audit organization, enhancing predictive compliance intelligence while mitigating risks through advanced analytics and effective audit strategies...
1 month ago
$132K - $199K *
Lead the charge in driving Professional Services sales and client success within the US Public Sector, collaborating across teams to maximize revenue, enhance client relationships, and ensure successf...
Yesterday
Director, Talent - Talent Management
$110K - $120K *
Elevate talent management by executing core programs, enhancing employee experience, and driving performance initiatives. Lead cross-functional projects, ensuring accountability and operational contin...
1 week ago
$120K - $145K *
Champion the development of clinical operations by managing a network of providers, establishing policies, and enhancing quality programs. Collaborate with leadership to ensure operational excellence...
6 days ago
Financial Examiner Lead (Director/MD/Partner)
$81K - $153K *
Champion financial examinations by leading teams to ensure quality, compliance, and timely delivery of regulatory services. Foster client relationships, manage complex projects, and drive growth in a...
Reposted 1 week ago
Senior Managing Counsel-Pharmacy Network Operations
$197K - $328K *
Shape the future of pharmacy network operations by leading a team of attorneys, providing strategic legal counsel on regulatory, operational, and transactional matters within the PBM landscape, while...
Reposted 6 days ago
Director, Partnership Tax- National Tax
$231K - $334K *
Elevate your career by leading partnership tax initiatives, providing expert guidance on complex federal tax matters, and collaborating with professionals to develop tailored solutions that drive clie...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.