Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director/Senior Director of Sales
$320K - $400K *
Join a team that's transforming utility operations through innovative sales strategies. Drive enterprise deals and shape climate resilience with executive leaders as you champion the PreventionFirst P...
4 weeks ago
Sr. Director, eDiscovery Technology & AI
$156K - $195K *
Champion the global eDiscovery Technology practice, leading a diverse team to innovate AI-assisted workflows, ensuring defensibility and quality across jurisdictions while driving growth and operation...
1 week ago
Director, Partnerships and Business Development - Southeast
$150K - $180K *
Transform your career by driving strategic partnerships in healthcare. Leverage your extensive relationships within benefits consulting to influence and expand business opportunities while collaborati...
Reposted 4 weeks ago
$99K - $118K *
Transform your career by leveraging your clinical and coding expertise to defend appeals for healthcare claims. This role demands independent analysis, strong communication, and proficiency in AI tool...
1 week ago
MGR, Contracting - Health Plan Relations (West Region)
$95K - $115K *
Drive managed care contracting activities, supporting payer negotiations and relationships. Collaborate with leadership to execute center-level priorities and enhance client satisfaction through effec...
1 week ago
Director, Audit Transformation
$150K - $180K *
Join a team that's redefining audit practices by leading the transition to an agentic operating model. Collaborate across functions to innovate audit methodologies and drive transformation for clients...
3 weeks ago
Senior Counsel - Data Governance, Privacy and Cybersecurity
$119K - $186K *
Advance your career by providing strategic legal counsel on data governance, privacy, and cybersecurity within a dynamic healthcare environment. Collaborate with cross-functional teams to drive compli...
1 week ago
National Account Director - Market Access & Payer Strategy
$175K - $185K *
Champion strategic payer engagement to enhance access and reimbursement across a national portfolio. Drive medical policy influence and build relationships with key stakeholders to expand coverage and...
3 weeks ago
Senior Director, Commercial Analytics & Decision Science
$219K - $285K *
Shape and lead a centralized commercial analytics function, transforming complex data into actionable insights. Drive performance measurement, growth identification, and strategic decision-making acro...
6 days ago
$110K - $130K *
Unlock potential by leading sales strategies in the renewable energy sector. Collaborate with cross-functional teams to engage clients, driving sales growth and building impactful relationships while...
Reposted 3 weeks ago
Healthcare Tech Manager - Epic Professional Billing
$130K - $150K *
Shape impactful healthcare solutions by leveraging your Epic Professional Billing expertise. Collaborate with diverse teams to optimize systems, enhance workflows, and drive meaningful results for cli...
3 weeks ago
$100K - $120K *
Elevate your career by driving product delivery excellence across teams. You'll ensure timely resolution of client requests and bugs, coordinating efforts between Product, Engineering, and Customer Ex...
3 weeks ago
Senior Director / Executive Director, Pharmacovigilance
$263K - $325K *
Advance your career by building and leading the pharmacovigilance function from the ground up. In this pivotal role, you'll oversee drug safety operations, collaborate with cross-functional teams, and...
Reposted 1 week ago
Revenue Operations Business Applications Manager
$115K - $125K *
Elevate operational efficiency by managing the integration and support of GTM systems. Drive enablement programs and streamline processes to empower sales teams, ensuring seamless data flow and effect...
2 weeks ago
$150K - $180K *
Drive the planning and execution of complex therapeutic programs from discovery to clinic. Serve as a senior program management partner, ensuring successful execution and alignment across cross-functi...
6 days ago
Medical Director -Pharmacy Appeals
$223K - $313K *
Shape the future of healthcare by leveraging your clinical expertise to review Medicare drug appeals, ensuring compliance and optimal value-based care through collaboration and analysis of complex cas...
6 days ago
Vice President, Finance & Accounting
$160K - $190K *
Take ownership of financial strategy and operations, leading a dynamic finance team to enhance performance, ensure compliance, and drive growth in a collaborative, employee-owned environment...
2 days ago
Director, GxP Quality Governance and Partnerships
$201K - $251K *
Champion Quality governance by leading the development and management of Quality Agreements across global operations, ensuring compliance and effective partnerships with internal and external stakehol...
Yesterday
Regional Sales Director - Large Enterprise Diversified Industries
$174K - $261K *
Empower enterprise transformation by leading a specialized sales team focused on cloud, data, and AI solutions. Drive strategic partnerships, coach high-performing sellers, and enhance technology stra...
1 week ago
Director, Debt Capital Markets
$150K - $180K *
Join a dynamic team to shape the future of multifamily debt strategy, ensuring asset protection and optimizing financing across acquisitions and refinances while driving investor returns through disci...
5 days ago
$160K - $190K *
Lead the charge in driving new business growth across complex technology solutions. Empower senior client relationships and oversee the complete sales lifecycle, leveraging expertise to navigate and n...
4 weeks ago
$190K - $230K *
Lead the accounting and financial reporting functions within a growing healthcare organization. Drive integrity across multiple entities, ensure compliance, and strategize cash management while suppor...
Reposted today
Director, Centralized Case Management
$110K - $130K *
Elevate your career by providing strategic leadership for a national remote case management team, ensuring service excellence, operational consistency, and client satisfaction while collaborating with...
3 weeks ago
Manager, Applications, Epic Orders
$165K - $264K *
Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...
2 days ago
Lead Product Manager - Provider Direct Connect
$126K - $173K *
Champion the development of Provider Direct Connect capabilities, driving product vision and strategy while collaborating with cross-functional teams to enhance provider engagement and deliver scalabl...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.