Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$110K - $130K *

Lead the charge in enhancing clinical operations and patient care in an ambulatory surgical setting. Oversee staff performance, implement process improvements, and ensure compliance with safety measur...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Drive quality excellence in clinical programs by overseeing compliance, risk management, and vendor oversight. Collaborate cross-functionally to ensure adherence to GCP regulations and lead inspection...

San Francisco, CARemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Drive quality oversight for clinical studies, ensuring compliance and risk management. Collaborate with cross-functional teams to implement quality strategies and serve as a trusted advisor, enhancing...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$195K - $240K *

Shape the future of strategic initiatives by leading cross-functional teams to drive impactful projects in North America. Collaborate with senior leadership to align strategies, evaluate progress, and...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Innovate laboratory operations by leading a team to enhance efficiency, compliance, and strategic alignment. Oversee budget management, quality initiatives, and technological advancements to support c...

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $125K *

Oversee clinical operations and lead interdisciplinary teams to enhance patient recovery through evidence-based practices and individualized care in a dynamic behavioral health setting...

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$90K - $95K *

Manage and oversee clinical support teams, ensuring adherence to policies, optimizing training outcomes, and maintaining high-quality client care while fostering effective communication across departm...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $170K *

Join a team that's driving innovative clinical research across multiple regions, leading teams to ensure on-time deliverables and high-quality data management in complex trials. Support site managemen...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Lead the charge in delivering exceptional care by overseeing operations, ensuring compliance, and fostering a high-performing team in a dynamic residential facility dedicated to teen behavioral health...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$132K - $307K *

Lead the charge in optimizing enterprise data operations, overseeing a team to deliver impactful analytics and reporting solutions. Collaborate with stakeholders to advance data-informed decision-maki...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$204K - $347K *

Drive the clinical development strategy, overseeing clinical trials and protocol design, while ensuring compliance and safety. Collaborate with cross-functional teams to meet patient-centered objectiv...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $140K *

Join a team that's dedicated to transforming healthcare through innovative philanthropy. As a key player, you'll manage donor relationships, drive fundraising efforts, and collaborate with diverse sta...

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$180K - $264K *

Lead the charge in GMP project management for non-viral drug manufacturing, coordinating cross-functional teams and external partners to ensure timely delivery of high-quality materials while mitigati...

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Lead the charge in strategic operations, partnering with executives to drive growth initiatives, optimize performance, and transform business strategies in a dynamic healthcare environment...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$138K - $231K *

Lead revenue cycle operations for a multi-site Center of Excellence, driving performance improvements, managing budgets, and mentoring teams to enhance billing accuracy and cash collections while ensu...

Texas, USRemote

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Transform strategic initiatives into actionable plans by partnering with leadership to drive growth, operational excellence, and business transformation in a dynamic healthcare environment. Engage in...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive strategic leadership in clinical and nursing research operations, enhancing evidence-based practices and fostering collaboration across interdisciplinary teams to improve patient and organizatio...

6 days ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$145K - $165K *

Lead the charge in clinical operations, overseeing patient care teams and ensuring compliance with regulations while managing administrative duties and budgetary oversight in a dynamic healthcare envi...

Today

  •   5 - 7 years exp.  •   Healthcare

$120K - $140K *

Unlock potential by leading clinical operations in hospice care. Oversee patient services, manage teams, and ensure compliance with regulations while driving quality care and operational excellence in...

Today

  •   5 - 7 years exp.  •   Healthcare

$234K - $251K *

Join a dynamic team as you lead clinical data management strategies, ensuring data integrity and compliance across multiple studies. Collaborate with cross-functional teams to drive quality and effici...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $165K *

Lead the charge in developing and managing Quality Improvement projects, collaborating with healthcare providers, and analyzing clinical practices to enhance patient outcomes and implement best practi...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$285K - $296K *

Elevate clinical data systems and programming by leading strategic initiatives, ensuring compliance, and optimizing technology platforms for efficient clinical trials. Collaborate across teams to driv...

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Champion the strategy and execution of clinical data management, ensuring data integrity and compliance for global marketing applications. Lead a dynamic team, oversee vendor relationships, and drive...

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Lead the charge in enhancing medical management for post-acute care, ensuring timely clinical decisions and effective case reviews. Collaborate with providers to uphold medical necessity standards and...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $150K *

Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.