Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$270K - $280K *

Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Oversee the operational planning and execution of clinical trials, ensuring compliance with regulatory standards while managing cross-functional teams to meet project timelines, budgets, and quality o...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Champion operational excellence in clinical trials by leading a team of Clinical Trial Managers. Drive strategic initiatives, ensure compliance, and enhance sponsor relationships while delivering stud...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive clinical trial success by overseeing operations, ensuring compliance, and enhancing team capabilities. Collaborate with cross-functional teams to optimize processes and mentor junior staff for c...

Blue Bell, PARemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$155K - $259K *

Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$150K - $180K *

Join a dynamic team to lead and scale clinical operations, overseeing performance and process optimization. Build accountable teams, manage metrics, and partner with stakeholders to enhance operationa...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Elevate clinical operations by leading teams in scheduling, coordination, and workforce planning. Drive performance through data insights while ensuring efficient processes and resource management as...

Addison, TXRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$154K - $242K *

Join a team that's redefining clinical operations by leading program strategies, ensuring high-quality execution of clinical studies, and collaborating with global partners to drive innovation and eff...

Massachusetts, USRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$136K - $171K *

Pioneer clinical trial excellence by leading operational planning and execution. Collaborate cross-functionally to ensure compliance, quality, and timely delivery of clinical studies while mentoring j...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $225K *

Drive operational excellence by leading care team operations and enhancing member experiences. Build scalable systems and processes to ensure consistent, high-quality interactions across all touchpoin...

New York, NYRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Manage clinical trial operations, ensuring compliance and performance across protocols. Oversee submissions, budgets, and team coordination while collaborating with internal and external stakeholders...

Quebec, CARemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$285K - $310K *

Lead the strategic execution of global clinical trials, ensuring adherence to timelines, budgets, and quality standards while fostering collaboration across teams and mentoring Clinical Operations per...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate clinical operations by leading daily workflows, managing teams, and spearheading impactful projects. Drive improvement and efficiency in healthcare delivery while fostering collaboration acros...

New York, NYRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a dynamic team to optimize clinical operations, ensuring compliance and performance excellence. Lead and develop Clinical Research Associates while managing resources and enhancing training initi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$227K - $341K *

Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Unlock operational excellence by managing administrative functions, recruiting, and onboarding for a growing inpatient practice. Collaborate with leadership to enhance staffing models and ensure compl...

Silver Spring, MDRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$246K - $332K *

Lead a dynamic team in shaping clinical development strategies for rare kidney diseases. Collaborate across functions to drive innovative trials, ensuring patient-centered approaches and operational f...

San Diego, CARemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$250K - $350K *

Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$108K - $156K *

Join a dynamic team as you oversee complex software deployments, ensuring governance and stakeholder engagement across multiple sites. Drive successful outcomes for strategic customers while managing...

Tucson, AZRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Lead the charge in developing competitive oncology strategies, ensuring client needs are met through collaboration and expertise. Drive business development and enhance client relations while overseei...

Raleigh, NCRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$225K - $275K *

Elevate healthcare standards by guiding medical policy and coding within a collaborative team. Leverage your expertise to enhance client relationships, improve payment accuracy, and drive strategic in...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$350K - $398K *

Drive impactful clinical trials in ophthalmology with leadership in study design, execution, and biomarker strategy. Collaborate cross-functionally to ensure timely delivery and regulatory compliance...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$115K - $135K *

Transform clinical trial operations by leading a dynamic team to ensure seamless execution of device-based studies, from feasibility to close-out, while driving process improvements and fostering cros...

Boston, MARemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K - $260K *

Join a fast-paced team of medical professionals to evaluate and enhance service appropriateness through evidence-based guidelines, impacting quality patient outcomes across multiple specialties while...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.