Explore $100K+ Jobs in California

Discover professional opportunities across California with Ladders. From established business centers to growing regional economies, the state offers senior-level roles in technology, healthcare, finance, entertainment, manufacturing, and more. Browse vetted job listings with salaries of $100,000 or higher and find positions that align with your experience and career goals.

California industries and career opportunities

California’s diverse economy supports leadership and specialized roles at companies of all sizes. Depending on your background, you may find opportunities in software and technology, life sciences, healthcare, financial services, clean energy, media, aerospace, and professional services. Job availability and compensation vary by role, employer, and location.

Find jobs throughout the state

Explore openings in major employment centers such as Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and surrounding communities. Listings may include on-site, hybrid, and remote arrangements; review each posting for its work location and requirements.

Search with Ladders

Use Ladders to focus your search on vetted professional jobs paying $100,000 or more. Review role responsibilities, qualifications, compensation details, and workplace expectations, then apply directly to opportunities that fit your goals. Keep your profile and resume current so employers can better understand your experience.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in California

Average Salary in USD

Average Salary: $142,597

Sort By: Relevance

$152K - $253K *

Shape the future of healthcare by leveraging health information technology to enhance care delivery. Collaborate with health systems and cross-functional teams to align HIT capabilities with clinical...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Lead the strategic alignment of R&D and IT, ensuring compliance and scalability of Veeva systems. Drive technology roadmaps, manage vendor relationships, and mentor junior partners while enhancing reg...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$82K - $89K *

Engage in groundbreaking projects within the Nuclear Design group, driving engineering solutions and support for global nuclear power plants, enhancing safety and efficiency through innovative designs...

Reposted today

  •   Less than 5 years exp.  •   Real Estate & Construction

$200K - $275K *

Lead the development of off-board AI evaluation frameworks to optimize safety and performance for autonomous vehicles. Collaborate with cross-functional teams to design scalable systems and enhance di...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Transportation

$240K - $333K *

Unlock the potential of AI by bridging technical model development and public policy. Collaborate with cross-functional teams to shape regulatory strategies and ensure alignment with cutting-edge AI a...

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Shape the future of engineering oversight by managing design and drafting teams, enforcing standards, and driving project success across refinery and petrochemical sectors, while mentoring the next ge...

Reposted today

  •   8 - 10 years exp.  •   Energy & Utilities

$191K - $222K *

Lead a dynamic team in managing respiratory care services, focusing on innovative solutions and compliance. Drive improvements at multiple sites while fostering collaboration, clinical expertise, and...

Reposted today

  •   Less than 5 years exp.  •   Staffing

$222K - $257K *

Transform healthcare delivery by leading maternal child health initiatives, optimizing patient care systems, and fostering collaboration among clinical teams to ensure safety and quality across multip...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$222K - $229K *

Reimagine quality care delivery in a fast-paced environment by supervising clinical operations, enhancing patient experience and safety, and collaborating with healthcare teams to meet clinical standa...

Reposted today

  •   5 - 7 years exp.  •   Staffing

$176K - $269K *

Lead a high-performing systems engineering team to design and verify next-gen spaceflight systems, ensuring safety and quality through disciplined engineering practices and innovative problem-solving...

Today

  •   11 - 15 years exp.  •   Aerospace & Defense

$88K - $104K *

Elevate your AV expertise by enhancing corporate events and meetings. You'll manage audio and video quality for live events, maintain AV equipment, and collaborate with teams to ensure seamless experi...

Today

  •   Less than 5 years exp.  •   Consumer Technology

$105K - $120K *

Transform patient care by leading a dedicated nursing team, ensuring quality service delivery, and enhancing operational efficiency in a dynamic healthcare environment. Drive clinical excellence and f...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$105K - $120K *

Transform patient care by leading a dedicated nursing team, ensuring quality service delivery and compliance. Drive clinical excellence and staff development while coordinating patient care across mul...

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$121K - $181K *

Lead your career with a dynamic role in corporate tax management, overseeing compliance, planning, and ASC 740 accounting. Collaborate with teams to deliver exceptional client service while mentoring...

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$120K - $140K *

Provide expert pharmacy consulting and clinical services, ensuring medication safety and compliance. Mentor team members while delivering compassionate care and navigating patient needs in a collabora...

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$120K - $140K *

Lead pharmacy operations by providing expert consulting services, educating patients on medications, and ensuring compliance. Drive clinical healthcare services while mentoring a collaborative team to...

Today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Unlock your potential by driving sales of innovative pulmonary solutions. Collaborate with diverse stakeholders to enhance patient care and achieve sales targets in a dynamic healthcare environment. J...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Innovate data-driven strategies to enhance business decision-making and optimize reporting processes. Leverage expertise in BI, CRM Analytics, and Salesforce to deliver actionable insights and support...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$182K - $207K *

Engage with healthcare professionals to promote innovative diagnostic solutions, driving adoption of AI-enhanced technologies in prostate cancer care. Collaborate across teams to achieve sales targets...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$78K - $92K *

Transform building repair and rehabilitation through innovative structural solutions. Collaborate with multidisciplinary teams to conduct assessments, prepare detailed reports, and support project pla...

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$229K - $310K *

Drive project management and business development to enhance operational efficiency in life sciences R&D, while leading diverse teams and ensuring profitability through strategic customer engagement a...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Transform enterprise learning by leading a team to design impactful solutions. Drive employee development, align training with business goals, and optimize learning technologies for enhanced performan...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K - $110K *

Champion legislative initiatives by developing and implementing policy priorities for the Tribe. Collaborate with stakeholders, analyze legislative impacts, and advocate for Tribal interests at local...

Today

  •   5 - 7 years exp.  •   Hospitality & Recreation

$160K - $205K *

Engage as a pivotal Security Engineer, focusing on hardware security initiatives, design reviews, and threat modeling. Collaborate across teams to implement secure-by-default components and drive secu...

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Empower communities by delivering compassionate, patient-centered care as a Family Nurse Practitioner. Collaborate with a dedicated team to enhance health outcomes for diverse populations and thrive i...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in California?question toggle

    California listings may include senior and specialized roles in technology, healthcare, finance, life sciences, entertainment, clean energy, manufacturing, and other fields. Available positions depend on current employer needs.

  • Where in California can I search for jobs?question toggle

    You can explore opportunities across the state, including major employment hubs such as Los Angeles, San Francisco, San Diego, San Jose, and Sacramento. Check each posting for its specific location and work arrangement.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review each listing for compensation information and details, since pay can vary by position and employer.

  • Can I find remote or hybrid California jobs?question toggle

    Some listings may offer remote or hybrid work, while others require on-site work. The job posting provides the employer’s location and work arrangement requirements.

  • How can I improve my California job search?question toggle

    Narrow your search by role, location, industry, and work arrangement. Keep your resume and profile updated, and carefully compare each opportunity’s qualifications and compensation details.