Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$80K - $95K *

Transform complex cybersecurity narratives into engaging content that captivates audiences across various formats. Collaborate with cross-functional teams to enhance brand storytelling and drive conve...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Lead the charge in developing client relationships and driving new business opportunities in the Life Sciences sector. Utilize a consultative sales approach to create bespoke marketing campaigns and m...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $150K *

Elevate digital partnerships by driving growth and engagement through strategic planning and relationship management. Collaborate with cross-functional teams to optimize performance and expand technol...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $135K *

Join a team that's driving enterprise growth by identifying new business opportunities and forming strategic relationships. You'll navigate complex sales cycles and engage with senior leaders to tailo...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Media

$95K - $115K *

Lead the implementation and management of client Speaker Bureau operations, ensuring successful educational programs in the pharmaceutical sector. Collaborate with cross-functional teams to exceed cli...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$231K - $340K *

Partner with us to drive sales of innovative cybersecurity solutions, cultivating strong client relationships and exceeding quotas in the TOLA territory. Leverage your expertise to deliver impactful s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Engineer innovative data products that empower global businesses. Lead cross-functional teams to define product strategy, manage lifecycles, and drive performance metrics, ensuring alignment with mark...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $105K *

Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion innovative design solutions for B2B2C platforms, driving user-centric experiences while balancing stakeholder needs. Collaborate across teams to elevate product quality and scalability, ensur...

Missouri, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$150K - $180K *

Drive growth and scale by leading customer engagement and solution implementation in the Banking and Financial Services sector. Identify opportunities, nurture relationships, and exceed revenue target...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$229K - $267K *

Optimize consumer acquisition strategies to drive growth and innovation across multiple channels. Lead a high-performing team, manage budgets, and define future goals while ensuring effective executio...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$166K - $200K *

Lead the charge in strategic account management by building and nurturing C-suite relationships, guiding a matrix team, and executing high-level strategies for national accounts and cancer centers acr...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K *

Shape the future of client success by leveraging insights and data to enhance program impact. Collaborate with leaders in law firms and professional services to drive engagement and talent development...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Elevate customer relationships by owning a strategic account portfolio, driving growth through consultative selling and collaboration across teams. This senior role demands proactive engagement and a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$286K - $315K *

Join a team that drives growth by managing strategic accounts and fostering relationships. You'll coordinate with various teams to ensure successful adoption of solutions within large enterprises whil...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Join a team that's driving innovative media strategies and partnerships. Oversee planning and execution of media investments across diverse channels, ensuring alignment with client objectives while fo...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$115K - $135K *

Drive strategic growth by managing a diverse portfolio of accounts. Lead and mentor an account management team to enhance client relationships and maximize profitability through innovative solutions a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$140K - $155K *

Engage with strategic enterprise clients to drive retention, growth, and satisfaction. Lead account strategy, advise stakeholders, and deliver measurable outcomes while mentoring team members and fost...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $150K *

Unlock your potential by leading enterprise accounts, driving revenue growth, and building strategic relationships. Become the trusted partner for clients as you deliver value through tailored solutio...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$189K - $255K *

Drive strategic sales initiatives by developing account plans, fostering C-level relationships, and leading negotiations to maximize customer success and revenue growth across a diverse product portfo...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $96K *

Join a dynamic sales team to drive growth through full-cycle sales, leveraging your expertise in Software/SaaS. Engage with C-suite executives, conduct demos, and exceed quotas while managing complex...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$130K - $155K *

Drive creative excellence as a key leader, managing cross-functional teams to deliver innovative solutions and strategic insights while nurturing client relationships and maintaining high creative sta...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Join our team to drive sales across innovative solutions, engaging with HR and finance stakeholders. You'll build pipelines, close deals, and shape our market approach for new products, all while coll...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's dedicated to driving growth in healthcare accounts. Leverage your strategic sales expertise to build relationships, identify opportunities, and deliver value in a fast-paced environ...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Unlock growth by leading sales initiatives and driving new opportunities in Salesforce services. Collaborate with teams to develop strategic solutions, manage client relationships, and exceed revenue...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.