Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Sterile Processing Manager / Account Manager - St. Louis, MO
$95K - $110K *
Lead the charge in managing hospital partnerships, ensuring operational excellence, team development, and client satisfaction while driving growth and compliance in a fast-paced healthcare environment...
4 weeks ago
Vice President, Commercial Pricing - REMOTE
$210K - $230K *
Lead the charge in developing enterprise pricing strategies that optimize profitability and drive growth across diverse service sectors, ensuring alignment with market conditions and client needs whil...
1 week ago
$120K - $140K *
Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...
Reposted today
$160K - $190K *
Join us as a strategic advisor, providing legal counsel on commercial contracts, AI products, and technology licensing. Collaborate with cross-functional teams to drive proactive solutions and support...
3 weeks ago
$90K - $120K *
Unlock potential by leading day-to-day accounting operations, ensuring accurate financial reporting, and driving process improvements in a dynamic e-commerce environment. Collaborate across teams to e...
3 weeks ago
Sr Director, Executive Hospitality & Client Experience
$175K - $185K *
Elevate executive and client experiences by designing luxury hospitality programs across a national portfolio, ensuring exceptional service standards and memorable interactions in corporate environmen...
Reposted 1 week ago
$120K - $155K *
Join a team that's dedicated to nurturing and expanding client relationships in the Major Market sector. Drive revenue growth through upselling and cross-selling while ensuring long-term satisfaction...
Reposted today
$125K - $190K *
Accelerate progress at a leading Customer Success team, driving renewal outcomes and enhancing team effectiveness through innovative engagement strategies and AI-driven solutions for a diverse portfol...
1 week ago
Vice President of Information Technology and Security
$180K - $220K *
Strategize and oversee the development of a cohesive IT and cybersecurity strategy to support a high-growth B2B software organization, ensuring alignment with business goals and compliance standards w...
2 days ago
Account Executive - Agriculture
$82K - $108K *
Accelerate growth by identifying and securing new business opportunities in agriculture. Leverage industry expertise and consultative selling to engage decision-makers, build pipelines, and drive cust...
2 weeks ago
$100K - $120K *
Shape the future of branch operations by leading a dynamic team, driving financial success, and fostering strong customer relationships while ensuring safety and quality in project execution...
1 week ago
Senior Sales Director - Life Science
$120K - $230K *
Unlock potential by driving strategic sales in the Life Sciences sector. Engage with key stakeholders, shape IT solutions, and achieve ambitious growth targets while leveraging your extensive network...
3 weeks ago
$80K - $85K *
Drive your career forward by managing operations that boost sales, profitability, and customer satisfaction. Lead a dynamic team, oversee financial management, and develop strategic plans to enhance m...
5 days ago
$88K - $105K *
Lead and manage complex multidisciplinary design projects, ensuring high-quality execution and fostering strong client relationships. Collaborate with diverse teams to deliver on time and within budge...
4 weeks ago
$175K - $210K *
Lead the charge in shaping post-quantum security solutions. Drive partnerships, develop the semiconductor ecosystem, and empower the commercial team with technical insights to create demand and establ...
Yesterday
Account Executive Retail - US Countrywide
$90K - $110K *
Grow your career with a dynamic role focused on sales success and account management. Drive profitable solutions in the retail sector while fostering long-lasting customer relationships and delivering...
Reposted 2 weeks ago
Regional Vice President Optics - West
$94K - $128K *
Lead and optimize sales teams to drive revenue growth and enhance client relationships. Collaborate with cross-functional teams to implement strategic plans, ensuring customer success and market expan...
1 week ago
Director, Strategic Initiatives
$149K - $205K *
Elevate innovation at the forefront of foodtech, agritech, and infrastructure. Lead strategic initiatives, build ecosystems, and drive new ventures to shape the future landscape of Mitsubishi Electric...
1 week ago
Professional (Senior) Sales Representative, Pain - Philadelphia, PA
$100K - $162K *
Join us to develop strategic business plans and conduct effective sales presentations while achieving goals in the pharmaceutical territory. Build relationships, influence key stakeholders, and drive...
Reposted 1 week ago
Senior Sales Executive, Strategic Banking
$130K - $160K *
Lead strategic banking initiatives by leveraging your enterprise sales expertise to build relationships and drive new business within Tier 1 global banks, shaping our go-to-market strategy and establi...
4 days ago
Senior Director, Drug Substance Commercial Manufacturing
$241K - $295K *
Drive drug substance commercial manufacturing excellence by leading technology transfer, operational oversight, and continuous improvement initiatives across multiple CDMO sites, ensuring alignment wi...
Yesterday
Mid-Market Account Executive - Public Sector (Southwest)
$152K - $190K *
Join a team that's transforming industries through IoT solutions, driving impactful sales from prospecting to closing. Engage with executives, build lasting relationships, and thrive in a high-perform...
Reposted 5 days ago
Regional Manager - Spine - Midwest & North Central
$200K - $250K *
Champion the growth of Spine product sales across the Midwest and North Central regions. Lead training initiatives, manage agency performance, and drive strategic sales efforts to enhance market prese...
Reposted 3 days ago
$175K - $210K *
Empower your marketing expertise to drive strategy, revenue, and brand positioning across multiple segments. Lead a dynamic team, collaborate with executives, and shape customer advocacy initiatives t...
2 weeks ago
Director, Supply Chain Planning & Materials
$130K - $176K *
Empower a dynamic team by leading supply chain strategies, enhancing material availability, and optimizing inventory management across multiple sites to meet business goals and customer commitments in...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.