Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Pharmacy Manager, Medical Pharmacy
$113K - $170K *
Elevate medical pharmacy services by leading clinical, financial, and operational strategies across diverse business segments. Drive policy development, manage drug costs, and ensure compliance while...
4 weeks ago
Director, Solutions Architecture
$160K - $180K *
Lead a high-performing team of Solutions Architects to drive strategic market expansion and enhance presales execution. Collaborate across functions to ensure alignment and deliver impactful solutions...
Today
Director, Enterprise Sales (SLED)
$165K - $220K *
Transform the SLED sales landscape by leading a high-performing team, driving new business, and fostering relationships within the Public Sector. Collaborate across departments to achieve ambitious sa...
Yesterday
Program Manager, Quality & Commissioning, NA
$120K - $130K *
Champion quality and commissioning excellence across diverse construction projects, ensuring compliance and safety while fostering collaboration among teams and stakeholders to drive impactful results...
2 weeks ago
Director of Business Development
$150K - $180K *
Lead the charge in developing and executing business strategies to acquire new clients, expand market reach, and drive sustainable revenue growth through consultative selling and strategic relationshi...
1 week ago
$110K - $130K *
Champion seamless technical integrations by leading end-to-end delivery, troubleshooting, and documentation. Collaborate with customer IT teams to ensure compliance and optimize data flows in a dynami...
4 weeks ago
$100K - $120K *
Empower healthcare organizations by driving sales of innovative Nurse Call solutions. Own the full sales cycle, engage with senior leaders, and leverage your expertise to navigate complex deals in a d...
1 week ago
$80K - $95K *
Lead the charge in overseeing complex industrial construction projects nationwide, ensuring safety, quality, and timely execution while mentoring field teams and coordinating trade partners for optima...
4 weeks ago
Major Accounts Executive, West
$150K - $180K *
Pioneer growth in strategic enterprise accounts by navigating complex sales cycles, building consensus among security-focused stakeholders, and closing multi-year contracts in a competitive market. Dr...
2 weeks ago
Stonehaven - Director of Credit & Collateral Risk
$200K - $450K *
Drive independent credit review and risk management for all counterparties, ensuring compliance and security across diverse financial entities. Collaborate with cross-functional teams to uphold rigoro...
2 weeks ago
Senior Product Builder, Partner Integrations
$122K - $180K *
Accelerate product development by defining, designing, and prototyping features for partner integrations, leveraging AI tools and user feedback to enhance payment processing solutions and maintain com...
1 week ago
Key Account Leader, Mid Cities East
$110K - $140K *
Lead the charge in driving sales for mid-sized public safety agencies, managing full-cycle deals from opportunity identification to closing. Collaborate with cross-functional teams to ensure successfu...
5 days ago
$110K - $130K *
Partner with us to tackle complex operational challenges, driving impactful initiatives across our portfolio. This role offers hands-on experience and growth opportunities, ideal for future leaders ea...
5 days ago
$110K - $130K *
Lead the charge in driving revenue growth across a multistate territory by managing a team of Dealer Representatives. Oversee sales operations, strategic direction, and relationship building to achiev...
4 days ago
Director, Transactional Risk Monitoring
$125K - $150K *
Lead the charge in monitoring transactional risk for banking and treasury services, ensuring effective fraud detection and credit risk management across multiple program layers while driving resolutio...
2 weeks ago
$110K - $130K *
Join a dynamic team to lead tax engagements, consult on planning, and develop talent. Shape client success through strategic management and industry expertise while fostering a collaborative environme...
2 weeks ago
$110K - $130K *
Advance client success by leading tax engagements, mentoring teams, and driving strategic solutions. Leverage your expertise to enhance business processes and foster growth in a collaborative environm...
2 weeks ago
Director, Product Management, Consumer (Top-Funnel)
$184K - $324K *
Unlock your potential in this leadership role, where you'll drive product strategy and team excellence. Collaborate with cross-functional partners to enhance the consumer experience and deliver impact...
Reposted today
$97K - $156K *
Elevate global tradeshow success by leading strategy, planning, and execution. Drive brand awareness and customer engagement while managing cross-functional partnerships and delivering measurable impa...
Reposted 2 days ago
Director, Technology Innovation COE
$119K - $186K *
Transform the future of supply chain technology by leading innovation initiatives, managing a structured evaluation process, and engaging stakeholders to drive measurable value and strategic alignment...
2 weeks ago
$80K - $95K *
Grow your career by managing strategic accounts, driving revenue, and fostering long-term relationships. Leverage expertise in solution selling and account management to deliver customer-centric strat...
Reposted 2 weeks ago
Manager, Sales Development | United States | Remote
$138K - $159K *
Empower growth by leading our US Sales Development team, driving pipeline success and fostering a collaborative culture. You'll partner with cross-functional leaders to enhance strategy and performanc...
Yesterday
General Superintendent - St Louis, MO
$90K - $110K *
Unlock your potential by leading on-site construction operations, ensuring safety, quality, and timely project completion. Collaborate with teams to manage resources, resolve issues, and drive success...
1 week ago
$80K - $95K *
Join a team that's dedicated to optimizing data-centric applications. As a Systems Applications Engineer, you'll ensure critical systems run smoothly, collaborating with stakeholders and mentoring jun...
2 weeks ago
$201K - $251K *
Lead strategic forecasting initiatives to drive decision-making in oncology. Collaborate with cross-functional teams to develop long-term models and communicate insights that shape product and portfol...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.