Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$110K - $160K *
Lead the charge in driving growth and strategy for our largest pro partners by leveraging data insights. Manage cross-functional projects to shape impactful initiatives, build frameworks, and measure...
Reposted 3 weeks ago
$150K - $180K *
Join a team that shapes the future of developer experiences, driving impactful design from concept to execution. Collaborate with engineers to redefine complex products and enhance usability across va...
Reposted 3 weeks ago
Director of Clinical Quality and Outcomes (BCBA-D Preferred)
$110K - $130K *
Innovate clinical quality systems for scalable care delivery, ensuring standards meet payer expectations and driving measurable performance improvements across independent health providers...
Reposted 3 weeks ago
$155K - $165K *
Transform the future of IoT connectivity by leading chipset and module enablement, guiding developers through the NB-IoT NTN journey, and optimizing solutions for real-world applications seamlessly...
Reposted 3 weeks ago
Account Director Senior - NeoCloud Enterprise
$139K - $185K *
Lead the charge in driving growth for major enterprise accounts by aligning customer priorities with Lumen's diverse portfolio, ensuring strategic execution from acquisition to expansion while advisin...
3 weeks ago
$130K - $150K *
Engage with a dynamic team to shape global total rewards strategies, ensuring competitive compensation and fostering employee satisfaction across varying tiers as the company scales and evolves...
Reposted 3 weeks ago
Strategic ABA Practice Partner
$100K - $120K *
Join a team that's focused on empowering ABA practice owners by enhancing operational performance, driving growth, and delivering tailored strategic solutions to complex challenges, ensuring high-qual...
Reposted 3 weeks ago
Senior Scientific Director - Publications (Heme-Onc)
$150K - $180K *
Join us to lead the development and oversight of scientific content across therapeutic areas, ensuring strategic medical communication aligns with brand goals while managing a team and collaborating w...
3 weeks ago
Customer Account Executive - K-12, EdTech
$90K - $130K *
Engage with K-12 districts to drive cross-sell revenue, leveraging existing relationships to introduce new product lines. Collaborate with teams to enhance student safety through technology while mana...
3 weeks ago
Staff Software Engineer, Developer Experience
$265K - $290K *
Shape the future of software development by leading an innovative AI-native platform that revolutionizes code generation and review, enabling engineers to build efficiently and collaboratively in a hi...
Reposted 3 weeks ago
$100K - $120K *
Explore opportunities in AI sales by managing key accounts, conducting discovery, and collaborating with teams to deliver tailored solutions. Engage in direct leadership collaboration and represent th...
Reposted 3 weeks ago
Senior Product Marketing Manager, WebApp
$180K - $230K *
Drive market dominance by owning the GTM strategy for innovative AppSec products, collaborating closely with technical teams and sales to ensure successful launches and impactful messaging that resona...
Reposted 3 weeks ago
$180K - $225K *
Drive backend engineering solutions that ensure scalability and reliability, collaborating closely with product teams. Own critical systems and adapt swiftly in a startup environment, delivering value...
Reposted 3 weeks ago
$105K - $176K *
Lead the charge in tax compliance and provision management, overseeing federal, state, and local returns. Collaborate cross-functionally to ensure timely filings and support tax strategies for busines...
3 weeks ago
Enterprise Account Executive, West
$300K - $350K *
Drive sales growth and expand customer accounts in the cybersecurity sector. Build relationships, exceed sales quotas, and manage Channel Partner engagements effectively to ensure customer satisfactio...
Reposted 3 weeks ago
$100K - $120K *
Transform customer experiences by owning agency accounts, driving adoption, and ensuring renewals. Enhance processes and collaborate within teams to translate feedback into actionable insights for a g...
Reposted 3 weeks ago
Staff Systems Software Engineer
$162K - $219K *
Champion the development of system integrity and speed across engineering teams, ensuring gameplay features are tested thoroughly and efficiently. Build the testing infrastructure that enhances qualit...
Reposted 3 weeks ago
Director, Corporate Communications and Brand
$153K - $200K *
Lead the charge in shaping corporate communications and brand strategy, enhancing market presence and credibility. Collaborate with executives and teams to amplify messaging and drive impactful initia...
3 weeks ago
Strategic Accounts Program Manager - Remote
$110K - $130K *
Shape the future of data center projects by managing strategic client relationships, overseeing multi-million-dollar initiatives, and ensuring operational excellence throughout the project lifecycle...
3 weeks ago
$110K - $130K *
Unlock potential by leading analytics initiatives—crafting measurement frameworks, overseeing implementation, and mentoring a junior specialist to enhance client performance through data-driven decisi...
Reposted 3 weeks ago
$120K - $145K *
Grow your career with a dynamic team leading threat intelligence and detection engineering. Shape strategies to protect diverse industries from cyber threats, while building a high-impact program that...
3 weeks ago
Video Host & Producer - Remote US
$110K - $160K *
Pioneer engaging video content by presenting and producing high-quality, relatable explainer videos. Collaborate closely with content strategists to ensure videos resonate with viewers while enhancing...
Reposted 3 weeks ago
Senior Manager, Solution Engineering - DocV
$135K - $160K *
Drive customer success and system reliability by leading a high-impact, agile engineering team focused on short-term initiatives that enhance product adoption and solve complex integration challenges...
Reposted 3 weeks ago
Senior Intelligence Analyst, DPRK & China Focus
$120K - $145K *
Unlock the potential of crypto intelligence by owning in-depth analyses of DPRK and Chinese financial threats, tracing illicit networks, and producing actionable insights for stakeholders across the g...
Reposted 3 weeks ago
Sr. Director, Product Marketing & Content
$170K - $200K *
Drive impactful product marketing strategies that translate complex AI technology into compelling narratives. Shape go-to-market initiatives, create high-value content, and enable sales teams to effec...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.