Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$145K - $213K *

Shape the future of competitive intelligence by leading win/loss analysis, market insights, and strategic positioning. Collaborate with product marketing to ensure data-driven decisions that enhance o...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$138K - $201K *

Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $250K *

Drive the development of a consumer credit card from concept to launch, focusing on user experience, underwriting, and rewards. Collaborate across teams to ensure a seamless product that meets custome...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $225K *

Tackle the procurement lifecycle for mission-critical cooling equipment in data centers. Lead strategic initiatives, supplier performance, and operational excellence, while managing risks and driving...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$195K - $265K *

Lead the strategic direction of General Medicine, integrating scientific and commercial insights to drive portfolio decisions and early pipeline projects, while fostering cross-functional collaboratio...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $230K *

Elevate your career by leading the design and optimization of HR operations. Drive compliance, enhance payroll accuracy, and build scalable processes that support a growing organization. Collaborate c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Join a team that's driving compliance solutions by leveraging your sales expertise to build relationships, influence decision-makers, and expand our customer base through strategic prospecting and col...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$67K - $111K *

Join us to drive software solutions by collaborating on design, coding, and testing. Contribute to quality assurance and user training while enhancing system reliability through proactive problem-solv...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $175K *

Unlock potential by managing federal sales strategies, driving relationships, and executing account plans to exceed quotas and revenue goals within the Federal Government and DOD sectors...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $205K *

Transform the future of client technology by leading architectural strategies and integrations in life insurance and annuity environments, ensuring alignment with enterprise goals and delivering scala...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$140K - $155K *

Lead the strategic direction and operations for a collaborative utility forum, driving key initiatives in electric distribution while engaging with senior utility leaders to enhance industry practices...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $135K *

Join a dynamic team as you provide strategic insights and operational support across Partnerships, Sales, and Marketing. Drive process improvements and data analytics to enhance partner performance an...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$88K - $154K *

Analyze and validate complex construction schedules, ensuring project milestones are met. Collaborate with clients to assess schedule health, identify risks, and propose mitigation strategies while ma...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$162K - $290K *

Drive the development of cutting-edge AI-driven safety solutions, leading firmware and full-stack initiatives. Collaborate across teams to shape technology strategy and deliver impactful products that...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Empower your career by driving project delivery and managing Agile teams. Utilize AI tools to enhance decision-making, anticipate risks, and ensure timely outcomes. Collaborate with stakeholders to ma...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Advance the success of teams by designing and delivering AI-powered learning experiences. Own the enablement lifecycle, collaborating with cross-functional teams to create engaging, measurable trainin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$118K - $180K *

Join a dynamic team to analyze solar PV energy yield assessments for utility-scale projects. Lead performance modeling and mentor engineers while expanding expertise across various renewable energy te...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $120K *

Join a dynamic team to drive sales growth by managing key accounts, developing relationships with C-level executives, and executing strategic sales processes to achieve targets in a defined territory...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$250K - $286K *

Shape the future of sales by leading a dynamic team to drive new business, refine strategies, and enhance customer experiences in a fast-paced SaaS environment, while mentoring leaders and achieving a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $145K *

Drive full-cycle recruitment efforts by innovating sourcing strategies and collaborating with senior leaders to attract senior talent across sales and business operations, while ensuring a seamless, e...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$94K - $276K *

Advance sales initiatives by managing the full sales cycle, building strong client relationships, and collaborating with internal teams to drive growth in the AI and Salesforce sectors. Make a signifi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$128K - $205K *

Elevate your career by owning the TA tech stack, driving integrations, and enhancing system efficiency. Collaborate with cross-functional teams to optimize processes and lead vendor relationships, all...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $180K *

Join a team that's dedicated to developing scalable software solutions, designing responsive UIs, and optimizing backend services. Collaborate across functions to drive innovation and champion best pr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $150K *

Pioneer the transformation of tax technology and processes, driving strategic initiatives to enhance operational efficiency, compliance, and user experience through automation and data-driven solution...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$111K - $200K *

Join a dynamic team as a subject matter expert in fuel quality inspections, ensuring compliance with industry standards and enhancing safety protocols across multiple airlines. Collaborate with peers...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.