Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$160K - $179K *

Shape the future of gameplay animation by creating high-quality character animations, collaborating with cross-functional teams, and driving the artistic vision while working independently to resolve...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$135K - $160K *

Champion modernization initiatives by designing and overseeing transformation solutions, integrating cutting-edge GenAI technology, and ensuring alignment with business objectives to drive impactful m...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$109K - $207K *

Drive strategic enterprise sales to Fortune 100/500 companies, leveraging strong negotiation skills and a proven track record to exceed quotas in a dynamic and collaborative environment...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining oncology care by overseeing clinical standards, evaluating therapies, and engaging with providers. You'll play a key role in shaping patient eligibility and treatment pro...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$129K - $168K *

Manage and elevate accounts payable operations by leading teams, optimizing workflows, and ensuring compliance with best practices. Collaborate cross-functionally to drive operational excellence and e...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$93K - $136K *

Elevate industrial design by creating detailed structural drawings and collaborating across disciplines. Utilize AutoCAD and CAD tools to support heavy engineering projects while ensuring safety and q...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$140K - $180K *

Join a team that's shaping the future of autonomous trucking by managing the integrated commercialization plan. Drive collaboration across departments to ensure seamless execution of milestones and de...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $115K *

Support high-voltage substation projects by performing detailed quantity takeoffs, material analysis, and constructability reviews. Collaborate with cross-functional teams to ensure accurate project b...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$110K - $138K *

Unlock potential by leading preconstruction for high-voltage electrical projects. Manage planning, estimating, and client coordination to ensure successful execution from concept to construction hando...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $95K *

Transform the recruitment and onboarding process by leading full-cycle talent acquisition, optimizing operations, and implementing AI-driven solutions to enhance efficiency and support for a growing c...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$102K - $125K *

Champion client success by leading a remote service team, driving process improvements, and managing complex data solutions. Collaborate across diverse teams to ensure timely deliverables and enhance...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$79K - $117K *

Support our partner marketing ecosystem by ensuring accurate data management, successful event coordination, and effective asset distribution, all while tracking budgets meticulously and empowering pa...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$88K - $105K *

Transform the travel industry by developing user-friendly web applications. Collaborate with cross-functional teams to create scalable solutions using modern technologies, ensuring high performance an...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$95K - $105K *

Drive revenue growth by managing territory plans and collaborating cross-functionally. Engage with key customers and analyze market trends to identify opportunities. Influence sales strategies while m...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Unlock potential by acting as the primary customer liaison, enhancing shipping strategies through strong partnerships, effective integration support, and deep parcel logistics expertise to drive optim...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$94K - $124K *

Lead operational excellence by managing our CLM platform, ensuring efficient contract processes and seamless collaboration among stakeholders, vendors, and technology to optimize procurement operation...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$113K - $135K *

Innovate sourcing strategies and manage vendor relationships to optimize talent procurement services across various categories, ensuring alignment with business needs while enhancing cost efficiency a...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Media

$110K - $130K *

Champion innovative solutions by collaborating with cross-functional teams to define and execute product strategies that enhance marketing technology, driving measurable business outcomes and client e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $130K *

Elevate your career by developing and maintaining core banking systems. Collaborate with teams to enhance application performance and reliability while utilizing your expertise in Profile Scripting La...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $150K *

Unlock potential by leading product marketing strategies for enterprise security buyers. Collaborate with Sales and Product teams to enhance positioning, create impactful materials, and drive successf...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$63K - $111K *

Lead the procurement process as a Senior Subcontract Administrator, managing subcontractor relationships, negotiating agreements, and ensuring compliance with industry standards. Drive efficiency in t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$100K - $120K *

Join a team that's dedicated to enhancing customer retention and growth in K-12 education. Lead a high-performing group of Renewal Representatives, driving performance, optimizing processes, and colla...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $130K *

Lead the charge in financial strategy for Avera at Home, collaborating with operational teams to drive revenue growth, optimize costs, and enhance financial performance across all locations while ensu...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $216K *

Drive business growth in the renewable market by developing innovative client solutions, mentoring teams, and collaborating across departments to meet evolving client needs and market challenges...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$111K - $150K *

Join a team that's advancing renewable energy solutions through expert power system analysis. Lead complex studies, collaborate with cross-functional teams, and drive innovative engineering practices...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.