Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Site Reliability Engineer, Provider Operations
$125K - $150K *
Join our team to enhance the operational health of AI provider endpoints. You'll ensure fast, reliable routing and proactive problem detection, contributing to a seamless experience for our customers...
2 weeks ago
Medical Science Liaison, Central US (Multiple Territories)
$155K - $175K *
Empower healthcare professionals by delivering scientific insights and fostering relationships. Drive prelaunch and launch strategies in a dynamic environment, ensuring clinical readiness and impactfu...
2 weeks ago
Manager, Home Center Analytics Enablement
$100K - $120K *
Transform data into actionable insights by leading analytics solutions that drive decision-making and improve performance. Collaborate across functions to establish trusted metrics and promote self-se...
2 weeks ago
Senior Implementation Project Manager - Healthcare Technology
$110K - $130K *
Lead the charge in complex software implementations for healthcare organizations, overseeing the full lifecycle from initiation to post-launch support while coordinating cross-functional teams and man...
2 weeks ago
Senior Lifecycle Marketing Manager - Partnerships
$115K - $145K *
Lead the lifecycle marketing strategy for partner-sourced users, enhancing activation, onboarding, and engagement. Collaborate cross-functionally to optimize experiences and drive measurable growth as...
2 weeks ago
IP and Technology Transactions Attorney
$170K - $200K *
Drive impactful legal strategies by leveraging your expertise in intellectual property and technology transactions. Join a dynamic team to negotiate contracts and advise on legal matters, contributing...
2 weeks ago
Senior Manager, Technical Program Management
$135K - $160K *
Lead the charge in shaping a new Technical Program Management team, guiding TPMs to deliver impactful results while fostering collaboration across Engineering and Product. Drive strategic planning and...
2 weeks ago
$143K - $200K *
Innovate solutions as a Senior Appian Developer, tackling complex BPM challenges. Collaborate with teams to design, implement, and optimize high-performance applications while mentoring junior develop...
2 weeks ago
Staff Product Operations Manager, Platform
$126K - $202K *
Lead impactful initiatives by analyzing data and building tools that drive revenue growth. Collaborate with product teams to identify gaps, streamline processes, and enhance enterprise readiness, ensu...
2 weeks ago
Senior Director, Strategic Accounts
$140K - $190K *
Empower our sales team by driving strategic growth in key accounts. Leverage your expertise in Enterprise SaaS to navigate complex sales in the Life Sciences sector, fostering partnerships and deliver...
2 weeks ago
Events and Field Marketing Manager
$97K - $132K *
Champion impactful events and drive engagement by managing all aspects of conferences and hosted gatherings. Collaborate with teams to enhance brand presence and ensure successful execution, while ana...
2 weeks ago
$107K - $154K *
Join us to manage Salesforce CPQ configuration and the requirements intake process. You'll oversee workflows, serve as a contact for users, and leverage AI tools to streamline requests and improve sol...
Reposted 2 weeks ago
Staff Product Manager, Growth & E-commerce Experimentation
$161K - $190K *
Transform the digital commerce experience by owning a high-velocity experimentation roadmap. Collaborate across teams to enhance customer journeys, improve conversion rates, and establish a robust exp...
2 weeks ago
Senior UX / Product Strategist - Sightline
$110K - $130K *
Transform user experiences by leading the design and strategy of a cutting-edge predictive marketing platform. Collaborate with cross-functional teams to create intuitive, data-driven interfaces that...
2 weeks ago
$65K - $220K *
Transform your career by joining a dynamic sales team focused on leadership development. Engage with clients, drive sales of premium workshop tickets, and unlock your potential for rapid advancement i...
2 weeks ago
$156K - $260K *
Empower cyber defense initiatives by designing, implementing, and optimizing advanced security solutions. Lead investigations, mentor teams, and enhance detection capabilities to proactively mitigate...
2 weeks ago
B2B Sales Partner - Entry Level
$75K - $100K *
Help us build lasting relationships with local businesses while providing tailored solutions. This role offers autonomy, teamwork, and personal growth opportunities in a supportive, high-performance c...
2 weeks ago
Senior Marketing Operations Manager
$145K - $185K *
Join a team that's driving marketing excellence by owning and scaling our marketing operations. You'll lead cross-functional projects, optimize tech stacks, and ensure data integrity to enhance pipeli...
2 weeks ago
$115K - $140K *
Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...
2 weeks ago
Director, Infrastructure Engineering
$170K - $250K *
Help us build a high-performing infrastructure team that drives operational excellence and reliability. Lead a diverse group of engineers, manage budgets, and modernize technology while collaborating...
2 weeks ago
People Technology Analyst - Workday
$95K - $160K *
Elevate People Technology by optimizing systems and processes, ensuring data integrity, and enhancing user experiences. Collaborate with cross-functional teams to drive efficiency and support a fast-p...
2 weeks ago
$110K - $130K *
Drive healthcare transformation by leading advanced consulting initiatives, enhancing delivery systems, and improving health outcomes. Collaborate with clients and stakeholders to implement strategic...
2 weeks ago
Director, Strategic Affairs, Business & Government
$125K - $150K *
Engage with policymakers and business leaders to drive revenue opportunities. Shape go-to-market strategies and government affairs initiatives, connecting teams to leverage policy insights for impactf...
2 weeks ago
Strategic Product Marketing Manager
$117K - $147K *
Lead the charge in shaping product marketing strategies that drive growth and market differentiation. Collaborate with cross-functional teams to execute go-to-market initiatives and influence product...
2 weeks ago
Human Resources Senior Associate, Recruiting
$80K - $100K *
Drive your career forward by managing the full recruiting lifecycle, collaborating with leadership to identify talent needs, and shaping a high-performing team that aligns with our mission and culture...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.