Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$82K - $131K *

Elevate customer engagement by driving successful project delivery, fostering collaboration across teams, and ensuring satisfaction through proactive communication and effective management of complex...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$110K - $130K *

Champion the digital experience by optimizing user flows, managing web content, and enhancing conversion strategies to drive engagement and pipeline growth for a leading B2B SaaS platform...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $100K *

Transform the landscape of B2B partnerships by engaging decision-makers, delivering customized solutions, and fostering long-term relationships in a dynamic, field-based environment. Shape your career...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Pioneer a high-performing culture by partnering with leaders to deliver strategic HR solutions that enhance employee engagement, retention, and growth in a dynamic, mission-driven environment...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $125K *

Elevate operational efficiency by managing the integration and support of GTM systems. Drive enablement programs and streamline processes to empower sales teams, ensuring seamless data flow and effect...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$149K - $185K *

Lead the strategy and execution of paid digital advertising programs, optimizing campaigns across multiple channels to drive measurable pipeline and revenue impact. Collaborate with cross-functional t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $110K *

Unlock potential by leading revenue recognition and compliance efforts, ensuring adherence to ASC 606 and GAAP standards. Collaborate with cross-functional teams to optimize revenue processes and enha...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$198K - $298K *

Champion the optimization of Sales systems and processes, driving productivity and strategic initiatives. Collaborate with cross-functional teams to enhance the sales experience and lead a global team...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$82K - $150K *

Elevate sales growth by aggressively prospecting and converting new dental implant accounts. Focus on expanding market share and positioning value-driven solutions while collaborating with internal te...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$103K - $120K *

Advance your career by reviewing and revising scientific claims for dietary supplements. Collaborate with cross-functional teams to ensure compliance and support product development while managing mul...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$80K - $95K *

Drive innovative design solutions that elevate brand identity across diverse media. Collaborate with cross-functional teams to create impactful visual assets, ensuring consistency and clarity in commu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $150K *

Empower members to fully engage with our product through strategic post-sale launches, driving adoption and enhancing user experience. Collaborate with cross-functional teams to ensure successful impl...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$61K - $250K *

Champion client success by building personalized financial plans and nurturing relationships. Drive your career forward in a dynamic environment focused on growth, collaboration, and continuous learni...

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$85K - $127K *

Seeking a skilled analytics manager to lead commercial data analysis, develop reporting solutions, and support pricing decisions. Collaborate cross-functionally to drive insights and enhance team perf...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$130K - $154K *

Shape the future of finance by owning financial planning and analysis for Consumer operations, driving efficiency, and enhancing resource allocation through data-driven insights across a dynamic growt...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$184K - $287K *

Drive the future of AI infrastructure by building automation and tools for large-scale GPU systems. Collaborate with cross-functional teams to enhance production reliability and ensure seamless operat...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$184K - $356K *

Transform the future of AI by optimizing generative models for efficiency. Collaborate with cross-functional teams to enhance automated deployment solutions, leveraging cutting-edge technologies in de...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Lead and innovate partner marketing strategies across diverse retail segments, managing a team to drive growth and enhance relationships. Collaborate cross-functionally to develop impactful campaigns...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$66K - $99K *

Elevate care standards by providing individualized nursing support to residents. Collaborate with families and interdisciplinary teams to ensure effective health maintenance and treatment, while leadi...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$173K - $310K *

Transform clinical AI solutions by leveraging your expertise in patient care and research. Collaborate cross-functionally to enhance clinical accuracy and support strategic partnerships, ensuring the...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$108K - $148K *

Join us as a Senior FP&A Analyst to drive financial planning, reporting, and forecasting. Collaborate across teams to optimize spending and enhance our financial systems, leveraging AI for insights th...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Empower customer success by designing and executing lifecycle programs that enhance adoption, retention, and expansion. Collaborate across teams to create impactful communications and leverage data-dr...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$82K - $150K *

Transform your career by driving growth in the dental implant market. Leverage your sales expertise to open new accounts, convert competitive users, and expand market share while delivering value-orie...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $170K *

Join a dynamic eCommerce team to enhance the online booking experience. Lead complex features in a Next.js and TypeScript application, impacting conversion and patient trust across multiple countries...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$106K - $163K *

Join a team that's dedicated to providing expert technical support and fostering exceptional customer service while leading a skilled group of specialists in delivering innovative product solutions an...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.