Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$125K - $150K *

Elevate partner relationships in a strategic leadership role responsible for guiding a team and enhancing partner success through AI-driven workflows and high-touch service...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$180K - $200K *

Lead the development of a robust risk and control framework, ensuring effective identification and management of risks in fiduciary and regulated financial services. Collaborate with stakeholders to e...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $120K *

Drive in-store execution and brand representation by building relationships, training teams, and enhancing merchandising across key accounts in California. Collaborate with sales teams to optimize cus...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Drive the development and maintenance of legacy MUMPS applications, collaborating with cross-functional teams to enhance healthcare systems and ensure seamless integration and support for end users...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$93K - $165K *

Champion partner implementation readiness by leading global enablement projects, designing scalable training programs, and creating high-quality certification content to empower partners in delivering...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$80K - $95K *

Collaborate to transform events and marketing programs into impactful executive engagement and demand generation. Drive planning, execution, and analysis to enhance partner campaigns and optimize sell...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Elevate project execution by leading a team of Control Technicians, ensuring quality, timely completion, and effective communication across all stakeholders while providing technical support and mento...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$210K - $250K *

Transform the payments landscape by leading strategy and execution across product, engineering, and operations. Drive growth and innovation in embedded payments, ensuring alignment and measurable outc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Shape the future of product strategy by leading a high-performing team, driving innovation, and ensuring alignment across operations and technology to deliver exceptional customer value and measurable...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $90K *

Join a dynamic team to drive client acquisition and revenue growth in the fintech sector. Leverage your expertise to build relationships with high-net-worth individuals and institutions, navigating co...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $120K *

Elevate B2B growth by forging high-trust partnerships with benefit consultants and health plans. Lead strategic discussions to position our behavioral health solutions, transforming relationships into...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in employee benefits by mentoring a sales team, driving growth, and fostering broker relationships. Utilize your expertise to educate clients and brokers on innovative solutions while...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$84K - $120K *

Accelerate insights generation as a key member of the Customer Analytics team, transforming raw data into actionable recommendations that enhance client retention, drive growth, and refine operational...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Elevate your career by providing clinical and administrative leadership, ensuring high standards of patient care while collaborating with medical staff and nursing personnel to drive strategic initiat...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $170K *

Lead a dedicated team to drive client success across diverse delivery modes, ensuring effective governance and coordination. Drive business development within a portfolio, nurturing critical client re...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$67K - $182K *

Lead the charge in driving operational excellence and strategic direction for a high-performing underwriting team, ensuring quality Medicare underwriting services that support profitable growth and bu...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Engage with stakeholders to shape a visionary strategy for Life and Annuities platforms. Leverage your extensive insurance expertise to define requirements, analyze markets, and drive product innovati...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Unlock compensation strategies by partnering with teams to analyze, model, and deliver data-driven solutions. Drive benchmarking, job architecture, and annual comp cycles to ensure equitable pay pract...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $200K *

Unlock potential by leading strategic accounts in ticketing, driving high-value sales and building influential relationships. Curate culturally relevant events while developing a robust sales pipeline...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Join a dynamic team as a strategic partner to senior living operators, driving adoption and ROI. Leverage your clinical expertise and commercial acumen to enhance client relationships and ensure succe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $95K *

Champion the development and implementation of ABA programs for individuals with autism and developmental disabilities, providing clinical supervision and collaborating with families to achieve treatm...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Unlock your potential by leading the development of innovative DRGV services, enhancing billing and coding optimization. Collaborate across teams to create scalable solutions that drive operational ex...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Transform the future of government contracting by leading cost estimation efforts. Collaborate with project teams to ensure compliance and accuracy in bids for civil and infrastructure projects, utili...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $150K *

Lead the technical authority for anaerobic wastewater treatment, driving innovation and optimization across a growing portfolio. Collaborate with cross-functional teams to enhance biogas production an...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$75K - $90K *

Transform your career by leading strategic SEM campaigns that enhance online visibility and drive conversions. Collaborate with innovative clients, analyze data, and optimize performance to exceed goa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.