Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Strategic Program Lead, GFCO
$130K - $154K *
Shape the future of financial crimes compliance by leading complex programs that enhance operational efficiency and regulatory adherence. Collaborate with cross-functional teams to drive strategic ini...
2 weeks ago
Senior Engineering Manager, AI Foundations
$253K - $298K *
Transform AI infrastructure by leading engineering efforts, driving innovation, and ensuring operational excellence across shared services. Collaborate with cross-functional teams to enhance security...
2 weeks ago
$110K - $130K *
Transform digital growth strategies by overseeing website, SEO, and campaigns. Drive content distribution, partner marketing, and harness AI for analytics, ensuring effective buyer engagement and meas...
Reposted 2 weeks ago
Director, Product Strategy & Monetization
$185K - $255K *
Transform the financial engine of R&D by leading revenue strategies, pricing, and cost management. Collaborate with senior leaders to align short-term goals with long-term product vision, while buildi...
2 weeks ago
Principal PATTS Consultant, State & Local Government
$140K - $210K *
Unlock the potential of Workday solutions by leading implementations, configuring systems, and ensuring client satisfaction. Collaborate with teams to document requirements, support data conversions...
2 weeks ago
Regional Sales Director - Northern California (NorCal)
$325K - $400K *
Join a team that's driving revenue growth in Northern California by leading a high-performing sales organization, developing strategic partnerships, and executing innovative go-to-market strategies in...
2 weeks ago
Sr. Strategic Commercial Banking Consultant
$125K - $157K *
Shape the future of commercial banking by leading strategic implementations, optimizing client operations, and advising on best practices to enhance financial institution capabilities and drive long-t...
2 weeks ago
$150K - $180K *
Transform enterprise AI solutions by designing and implementing Multi-Agentic AI architectures. Leverage expertise in Generative AI, cloud technologies, and governance to lead projects from proof of c...
2 weeks ago
Operations Manager, Global Strategic Accounts
$130K - $160K *
Drive operational excellence by leading a global team to deliver high-quality wellbeing programs. Collaborate with stakeholders to ensure effective execution, maintain standards, and enhance participa...
2 weeks ago
Strategic Business Development Executive
$150K - $180K *
Join a team that's driving innovation in legal technology by leveraging your extensive sales expertise to acquire new enterprise accounts and exceed revenue targets across the Americas, while collabor...
2 weeks ago
Staff Backend Engineer - Prompt Security (Node.js / TypeScript)
$156K - $215K *
Innovate backend infrastructure for AI security, ensuring compliance and risk assessment. Collaborate in a dynamic environment, enhancing scalability and security while shaping the future of cybersecu...
2 weeks ago
Strategic Account Manager Sr Lead
$177K - $301K *
Develop and lead strategic client growth initiatives, fostering executive relationships and aligning teams to drive long-term value, retention, and measurable outcomes across a portfolio of enterprise...
2 weeks ago
$110K - $130K *
Lead the charge in optimizing a fast-growing credit card portfolio, driving customer acquisition, engagement, and rewards economics while collaborating with partners and engineering teams to enhance p...
2 weeks ago
$95K - $115K *
Drive impactful product launches and marketing strategies in healthcare, managing therapy lines from execution to analysis. Collaborate cross-functionally to enhance provider engagement and optimize p...
2 weeks ago
Director, Onboard Core Software
$240K - $330K *
Champion the development of onboard software for autonomous vehicles, leading cross-functional teams to ensure a robust software foundation. Drive strategic vision, quality, and operational excellence...
2 weeks ago
Partner Development Manager, Strategic Payment Partnerships
$130K - $160K *
Drive strategic payment partnerships, enhancing user experiences through collaboration and execution of initiatives. Leverage expertise in fintech to manage relationships and align stakeholders, ensur...
2 weeks ago
Lead Solution Architect, Physical AI
$140K - $175K *
Transform the landscape of Physical AI by leading technical design and delivery of innovative systems that integrate computer vision, robotics, and digital twin technologies, ensuring seamless operati...
2 weeks ago
Principal, Strategic Alliances & Partnerships
$150K - $180K *
Lead the charge in building strategic partnerships that drive revenue and growth. Collaborate across teams to identify opportunities, negotiate agreements, and create impactful integrations that enhan...
2 weeks ago
Analyst I, Falcon Complete (Remote, PST/MST)
$85K - $120K *
Shape the future of cybersecurity by delivering real-time incident response and analysis. Collaborate with a dynamic team to protect organizations from sophisticated threats while enhancing your skill...
2 weeks ago
Associate, Corporate Development
$115K - $140K *
Drive impactful growth by mapping industrial markets, evaluating acquisition targets, and building investment models. Collaborate on live transactions to shape strategic decisions that enhance manufac...
2 weeks ago
$90K - $100K *
Lead the charge in shaping innovative creator ad campaigns, managing end-to-end processes while leveraging AI to enhance performance. Collaborate cross-functionally to deliver impactful content and ma...
2 weeks ago
$109K - $132K *
Tackle the integration and automation of finance systems, enhancing efficiency and accuracy. Collaborate with cross-functional teams to streamline processes, ensuring financial data flows seamlessly a...
2 weeks ago
$106K - $177K *
Unlock potential by leading cross-functional teams to shape product strategy, drive growth, and enhance customer value through data-driven insights and innovative solutions across the full product lif...
2 weeks ago
Corporate Development Manager - Medical Aesthetics
$140K - $170K *
Drive financial evaluations and execution of acquisitions in medical aesthetics, analyzing opportunities and supporting leadership in negotiations. This hands-on role requires expertise in financial a...
2 weeks ago
VP, Labor & Public Sector Sales
$215K - $250K *
Pioneer your career by leading a dynamic sales team focused on Labor and Public Sector markets. Drive growth, mentor talent, and execute strategic initiatives to exceed revenue goals while building im...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.