Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$130K - $154K *

Shape the future of financial crimes compliance by leading complex programs that enhance operational efficiency and regulatory adherence. Collaborate with cross-functional teams to drive strategic ini...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$253K - $298K *

Transform AI infrastructure by leading engineering efforts, driving innovation, and ensuring operational excellence across shared services. Collaborate with cross-functional teams to enhance security...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Transform digital growth strategies by overseeing website, SEO, and campaigns. Drive content distribution, partner marketing, and harness AI for analytics, ensuring effective buyer engagement and meas...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$185K - $255K *

Transform the financial engine of R&D by leading revenue strategies, pricing, and cost management. Collaborate with senior leaders to align short-term goals with long-term product vision, while buildi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $210K *

Unlock the potential of Workday solutions by leading implementations, configuring systems, and ensuring client satisfaction. Collaborate with teams to document requirements, support data conversions...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$325K - $400K *

Join a team that's driving revenue growth in Northern California by leading a high-performing sales organization, developing strategic partnerships, and executing innovative go-to-market strategies in...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $157K *

Shape the future of commercial banking by leading strategic implementations, optimizing client operations, and advising on best practices to enhance financial institution capabilities and drive long-t...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Transform enterprise AI solutions by designing and implementing Multi-Agentic AI architectures. Leverage expertise in Generative AI, cloud technologies, and governance to lead projects from proof of c...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$130K - $160K *

Drive operational excellence by leading a global team to deliver high-quality wellbeing programs. Collaborate with stakeholders to ensure effective execution, maintain standards, and enhance participa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Join a team that's driving innovation in legal technology by leveraging your extensive sales expertise to acquire new enterprise accounts and exceed revenue targets across the Americas, while collabor...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$156K - $215K *

Innovate backend infrastructure for AI security, ensuring compliance and risk assessment. Collaborate in a dynamic environment, enhancing scalability and security while shaping the future of cybersecu...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$177K - $301K *

Develop and lead strategic client growth initiatives, fostering executive relationships and aligning teams to drive long-term value, retention, and measurable outcomes across a portfolio of enterprise...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in optimizing a fast-growing credit card portfolio, driving customer acquisition, engagement, and rewards economics while collaborating with partners and engineering teams to enhance p...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Drive impactful product launches and marketing strategies in healthcare, managing therapy lines from execution to analysis. Collaborate cross-functionally to enhance provider engagement and optimize p...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$240K - $330K *

Champion the development of onboard software for autonomous vehicles, leading cross-functional teams to ensure a robust software foundation. Drive strategic vision, quality, and operational excellence...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Transportation

$130K - $160K *

Drive strategic payment partnerships, enhancing user experiences through collaboration and execution of initiatives. Leverage expertise in fintech to manage relationships and align stakeholders, ensur...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$140K - $175K *

Transform the landscape of Physical AI by leading technical design and delivery of innovative systems that integrate computer vision, robotics, and digital twin technologies, ensuring seamless operati...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in building strategic partnerships that drive revenue and growth. Collaborate across teams to identify opportunities, negotiate agreements, and create impactful integrations that enhan...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $120K *

Shape the future of cybersecurity by delivering real-time incident response and analysis. Collaborate with a dynamic team to protect organizations from sophisticated threats while enhancing your skill...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $140K *

Drive impactful growth by mapping industrial markets, evaluating acquisition targets, and building investment models. Collaborate on live transactions to shape strategic decisions that enhance manufac...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$90K - $100K *

Lead the charge in shaping innovative creator ad campaigns, managing end-to-end processes while leveraging AI to enhance performance. Collaborate cross-functionally to deliver impactful content and ma...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$109K - $132K *

Tackle the integration and automation of finance systems, enhancing efficiency and accuracy. Collaborate with cross-functional teams to streamline processes, ensuring financial data flows seamlessly a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$106K - $177K *

Unlock potential by leading cross-functional teams to shape product strategy, drive growth, and enhance customer value through data-driven insights and innovative solutions across the full product lif...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $170K *

Drive financial evaluations and execution of acquisitions in medical aesthetics, analyzing opportunities and supporting leadership in negotiations. This hands-on role requires expertise in financial a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$215K - $250K *

Pioneer your career by leading a dynamic sales team focused on Labor and Public Sector markets. Drive growth, mentor talent, and execute strategic initiatives to exceed revenue goals while building im...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.