Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior People Business Partner
$105K - $120K *
Drive strategic people initiatives as a trusted advisor, shaping talent strategies and leading change. Collaborate with leaders to enhance engagement, manage complex employee relations, and mentor HR...
2 weeks ago
Senior Manager, Communications
$150K - $215K *
Innovate by driving real-time communications strategies and partner engagement. Shape impactful narratives during breaking news while building scalable programs that connect communications outcomes to...
2 weeks ago
$110K - $130K *
Empower a high-performing technical support team by executing strategic communication plans, mentoring talent, and enhancing service delivery for payroll tax platforms, ensuring quality and customer s...
2 weeks ago
Senior Group Manager, Customer Success
$134K - $184K *
Shape the future of customer success by leading a high-performing team, optimizing operations, and driving engagement and retention strategies to achieve key performance indicators and enhance client...
2 weeks ago
$180K - $202K *
Drive customer success by serving as a technical expert, guiding implementations and optimizing strategies for Harness AppSec solutions. Collaborate with clients to ensure they achieve maximum value a...
2 weeks ago
$210K - $240K *
Lead strategic relationships with influential optometrists and ophthalmologists, shaping the Presbyopia ecosystem through education and engagement. Drive insights and collaboration across medical, mar...
2 weeks ago
Executive Director, Technology
$175K - $215K *
Elevate the technology function by leading engineering, delivery, and operations. Collaborate closely with leadership to shape technical strategy, ship code weekly, and ensure high standards in a dyna...
2 weeks ago
$95K - $115K *
Champion the monthly close process, ensuring accuracy and scalability across multi-entity operations while driving continuous improvement and automation in accounting practices...
2 weeks ago
$150K - $180K *
Contribute to the design and execution of clinical studies, ensuring data integrity and quality. Collaborate cross-functionally to drive study activities and support regulatory efforts, while enhancin...
2 weeks ago
$80K - $95K *
Inspire and lead a technical operations team to exceed performance goals, enhancing customer satisfaction while ensuring quality service and safety in fiber-optic network operations. Foster talent dev...
Reposted 2 weeks ago
Sales Director (New York Metro)
$160K - $180K *
Advance sales growth by leading a dynamic team, implementing strategic plans, and enhancing client relationships in a fast-paced environment. Drive performance through coaching and collaboration with...
2 weeks ago
Staff Software Engineer, Android Design System
$217K - $303K *
Lead the charge in evolving a cohesive design system for Android, enhancing UI architecture and performance. Collaborate with cross-functional teams to build reusable components and improve accessibil...
2 weeks ago
$80K - $95K *
Partner with us to enhance client success by designing tailored solutions, onboarding enterprise clients, and driving growth through consultative selling and relationship management, ensuring exceptio...
2 weeks ago
Program Executive, Early Phase
$300K - $350K *
Join a team that's driving innovation in early clinical development. Lead cross-functional strategies and execution for a high-priority program, ensuring alignment and decision-making to advance a pot...
2 weeks ago
Senior Data Scientist II, Monetization
$183K - $216K *
Take ownership of the scientific and product roadmap for monetization, leading audience creation and measurement methodologies. Collaborate with cross-functional teams to drive product strategy and in...
2 weeks ago
$80K - $95K *
Partner with us to enhance clinical IT solutions as an Epic Analyst II, providing critical support, training, and implementation for Epic EHR systems. Collaborate with teams to optimize workflows and...
2 weeks ago
Portfolio Director, Air and Space Force Programs
$157K - $283K *
Join a team that's shaping the future of defense by leading a dynamic portfolio of Air Force and Space Force programs, ensuring excellence in delivery, financial performance, and client relationships...
Reposted 2 weeks ago
Chief Product and Technology Officer
$210K - $250K *
Join us to lead product and technology strategy, driving innovation and integration across platforms while enhancing customer experiences and ensuring security and scalability in a dynamic, hands-on e...
2 weeks ago
Enterprise Account Executive- Southwest
$130K - $140K *
Unlock potential by driving growth in a dynamic territory, managing relationships with Enterprise customers, and maximizing revenue through strategic sales initiatives and collaboration across teams...
2 weeks ago
$119K - $180K *
Lead the development of innovative web platforms, collaborating with cross-functional teams to enhance content management systems. Drive technical decisions and foster a culture of growth while ensuri...
2 weeks ago
$110K - $130K *
Champion strategic reseller partnerships by sourcing, qualifying, and managing relationships across the partner lifecycle, driving growth and revenue through collaboration with internal teams and exte...
2 weeks ago
$85K - $95K *
Transform client relationships by delivering exceptional service and support, ensuring seamless communication and issue resolution while collaborating with internal teams to enhance client satisfactio...
2 weeks ago
Manager, Schedule and Cost Control
$100K - $120K *
Join a team that's dedicated to optimizing project planning and cost control for renewable energy initiatives. Lead efforts in scheduling, compliance, and reporting to ensure project success from ince...
2 weeks ago
Head of Analytical Development, Pulmovant
$160K - $200K *
Lead the charge in analytical development, overseeing drug substance and product strategies. Collaborate across teams to ensure compliance and performance, while mentoring a high-performing analytical...
2 weeks ago
Associate Director, Drug Product, Pulmovant
$130K - $160K *
Lead the technical direction for inhaled dry powder products, ensuring product performance and manufacturability while collaborating with cross-functional teams to navigate development and regulatory...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.