Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$100K *

Champion liberty and defend individual rights as you engage in impactful public-interest law through a dynamic year-long fellowship, working alongside experienced attorneys on crucial environmental ca...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$121K - $190K *

Transform employee relations by building a robust ER model, leading complex investigations, and empowering HR teams. Drive strategic initiatives while managing sensitive employee matters to create eff...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$89K - $143K *

Drive vendor governance excellence by coaching stakeholders, enforcing accountability, and facilitating training. Ensure compliance with vendor management policies while fostering a culture of continu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Manage and oversee finance operations, leading accounts payable and billing functions across multiple regions. Ensure accuracy and compliance in procure-to-pay and order-to-cash processes while buildi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$77K - $118K *

Elevate your drafting career by collaborating in a dynamic team, utilizing advanced CAD tools, and gaining hands-on experience in 3D design. Contribute to innovative projects that shape the future of...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$161K - $268K *

Unlock opportunities by managing oncology partnerships across Washington and Alaska. Drive business plans, enhance patient access, and collaborate with cross-functional teams to achieve impactful resu...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$87K - $108K *

Join a dynamic engineering team to deliver innovative electrical solutions. Collaborate on complex projects, mentor junior staff, and ensure compliance with industry standards while driving quality an...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$85K - $100K *

Join a team that's dedicated to building strong client relationships through face-to-face sales. Leverage your expertise in outside sales to drive growth and maximize your earning potential in a dynam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$120K - $140K *

Drive your career forward by leading a dynamic PMO team, overseeing complex projects in healthcare technology. Collaborate cross-functionally to ensure strategic alignment and successful execution of...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$233K - $275K *

Lead and empower a dynamic sales team to exceed revenue goals in a rapidly growing cybersecurity market. Drive strategic initiatives, foster relationships, and enhance pipeline generation while managi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$129K - $162K *

Join a team that's driving impactful fundraising initiatives across the Midwest. Lead strategic development efforts, cultivate high-value donor relationships, and secure significant gifts to support o...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$210K - $256K *

Unlock potential by leveraging your expertise in Telecom operations and AI-driven solutions. Collaborate with industry leaders to support and enhance service delivery for top communications service pr...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$154K - $193K *

Join a team that's transforming utility management through innovative GIS solutions. Leverage your expertise in ESRI technologies to lead projects, engage stakeholders, and drive efficiency across the...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$168K - $231K *

Transform the legal landscape by leading negotiations on enterprise deals, guiding teams through complex transactions, and enhancing Optro's contracting process as part of a dynamic legal team...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$272K - $340K *

Join a team that's driving CMC strategy and execution for innovative therapies. Lead cross-functional efforts in drug and device development, ensuring compliance and operational excellence from clinic...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$75K - $100K *

Join a team that's dedicated to delivering exceptional customer experiences while managing projects from inquiry to shipment. This role combines inside sales, project coordination, and technical revie...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$272K - $340K *

Lead the charge in shaping a global supply chain strategy that ensures seamless delivery of clinical and commercial products. Build a high-performing team and foster partnerships to meet regulatory st...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Help us shape the future of pulmonary care by leveraging your clinical expertise to drive product development, enhance workflows, and ensure effective solutions for COPD, asthma, and other pulmonary c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $130K *

Drive client growth by leveraging data-driven insights to enhance strategic relationships and deliver impactful solutions. Collaborate cross-functionally to achieve measurable outcomes and ensure clie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$190K - $220K *

Champion financial excellence by leading a dynamic team, driving strategic analysis, and leveraging AI to enhance decision-making for a diverse portfolio of clients in a fast-paced, remote environment...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Business Services

$130K - $160K *

Engineer AI-driven integrations and enhance platform capabilities while independently managing client engagements from discovery to certification. Collaborate with sales, design solutions, and ensure...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Transportation

$104K - $119K *

Shape the future of financial strategy by partnering with leadership teams to drive budgeting, forecasting, and analytics. Leverage your expertise to enhance operational efficiency and deliver insight...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Drive statutory financial reporting and audits, ensuring compliance and accuracy. Collaborate with cross-functional teams to enhance financial transparency and support leadership in understanding perf...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $140K *

Unlock your potential by leading enterprise sales for our innovative technology, driving strategic partnerships with large corporate insurance agencies and institutions. Own the sales cycle, navigate...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Shape the future of operations by managing resources, enhancing performance, and driving continuous improvement to achieve customer satisfaction and operational excellence in a dynamic environment...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.