Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Oncology Account Manager, Dallas East
$150K - $230K *
Accelerate your career by driving oncology product success and building impactful relationships with healthcare professionals. Lead strategic initiatives to enhance patient access and deliver innovati...
1 week ago
Senior Oncology Account Manager, Jersey South
$150K - $230K *
Lead the charge in promoting innovative oncology solutions while building strong relationships with healthcare professionals. Drive performance goals and enhance patient access through strategic engag...
1 week ago
Senior Oncology Account Manager, Phoenix East
$150K - $230K *
Optimize your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...
1 week ago
Senior Oncology Account Manager, Manhattan
$150K - $230K *
Join a team that's dedicated to advancing oncology care by promoting innovative treatments, building strong relationships with healthcare professionals, and driving patient access to essential therapi...
1 week ago
$150K - $180K *
Shape the future of commercial law by leading negotiations and advising on product launches. Collaborate with cross-functional teams to enhance legal processes and support strategic growth initiatives...
1 week ago
$149K - $173K *
Lead quality and food safety initiatives across North America, ensuring compliance and audit readiness. Drive continuous improvement and operational excellence through technical expertise and collabor...
1 week ago
Senior Regulatory Affairs Specialist
$83K - $103K *
Drive success in regulatory affairs by preparing critical submissions for medical and diagnostic devices. Oversee compliance with U.S. and international regulations while collaborating with cross-func...
Reposted 1 week ago
$90K *
Contribute to high-impact proposal development by crafting persuasive narratives that align with client needs and competitive positioning, ensuring compliance and strategic messaging throughout the pr...
1 week ago
Associate Director, CMC Operations
$155K - $190K *
Manage the planning and execution of CMC operations across multiple development programs, ensuring alignment with regulatory milestones and efficient collaboration with cross-functional teams and CDMO...
1 week ago
Human Resources Business Partner
$95K - $115K *
Serve as a strategic HR partner, guiding leaders and employees through employee relations, performance management, and compliance across multiple departments in a dynamic, remote environment...
1 week ago
1557- Director, Strategic Sourcing- Corporate Services
$125K - $185K *
Transform strategic sourcing for HR and Benefits, leading complex engagements and driving cost savings while ensuring high supplier performance and stakeholder satisfaction across diverse client needs...
1 week ago
Regional Quality Manager - W&L | 3PL
$120K - $160K *
Champion quality excellence by leading and standardizing assurance systems across regional logistics operations, driving continuous improvement and client partnerships while supporting new business la...
1 week ago
Solutions Architect, Enterprise
$224K - $326K *
Serve as a technical leader for large customers, guiding AI cloud strategies. Connect business priorities with scalable architecture while managing executive engagements and navigating complex decisio...
Reposted 1 week ago
$130K - $160K *
Lead the charge in delivering strategic and operational excellence across high-profile medical affairs accounts, fostering client relationships and guiding teams to achieve exceptional results in publ...
1 week ago
$85K - $105K *
Join a team that's dedicated to delivering impactful medical communications. As a Senior Account Manager, you'll lead strategic projects for pharmaceutical clients, ensuring quality and timely executi...
1 week ago
Senior Product Designer, Developer Foundations
$180K - $212K *
Lead the design of a comprehensive Developer Portal, enhancing the developer experience through intuitive interfaces and impactful improvements. Collaborate with cross-functional teams to drive user-c...
1 week ago
Senior Account Manager, Promotional Medical Education
$85K - $95K *
Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...
1 week ago
$170K - $240K *
Unlock potential by serving as a strategic technical advisor for key enterprise customers, guiding architecture decisions and aligning technical plans with business outcomes to ensure successful imple...
1 week ago
Bios Business Development Manager
$125K - $150K *
Unlock your potential by leading biostimulant strategies across North America. Collaborate with teams to drive product adoption, enhance profitability, and develop innovative solutions in the agricult...
1 week ago
Area Vice President, RTD & Convenience
$185K - $231K *
Champion a transformative growth agenda for RTD & Convenience, focusing on channel expansion, strategic partnerships, and market leadership to drive profitability and market share while collaborating...
Reposted 1 week ago
$110K - $130K *
Join a team that's dedicated to driving client success and growth by managing a substantial book of business. Leverage your expertise in account management to foster relationships and influence produc...
1 week ago
$135K - $155K *
Drive data science initiatives to transform clinical and real-world data into actionable insights, supporting cross-functional teams in medical device research and development. Collaborate effectively...
1 week ago
$90K - $120K *
Unlock quality assurance excellence by leading automation efforts and mentoring teams. Drive the development of robust testing frameworks and enhance product reliability across multiple platforms in a...
1 week ago
Customer Operations Manager, Gainsight
$99K - $124K *
Unlock potential by driving the creation and maintenance of Gainsight CSP content, ensuring seamless integration across marketing and RevOps. Lead quality assurance, collaborative workflows, and repor...
Reposted 1 week ago
$145K - $175K *
Join a team that's redefining AI-driven solutions by leading product development for an innovative tech concierge. Drive the evolution of agent capabilities, ensuring quality and reliability while col...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.