Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
$135K - $150K *
Elevate your career by leading product operations, enhancing processes, and driving AI adoption. Collaborate with cross-functional teams to optimize product delivery and analytics, ensuring seamless c...
1 week ago
Senior Director, Business Development
$194K - $266K *
Lead the charge in driving commercial growth by securing high-value partnerships and expanding market presence. Mentor a dynamic team while executing strategic initiatives that enhance client relation...
1 week ago
$125K - $150K *
Explore innovative solutions as a Senior Mobile Engineer, leading the design and architecture of mission-critical apps that empower our delivery fleet and operations teams, ensuring reliability and ef...
Reposted 1 week ago
Site Inspector Lead (Data Center Manufacturing Quality)
$100K - $120K *
Empower quality assurance excellence by leading inspections across North America, ensuring critical infrastructure meets project standards. Collaborate with suppliers and teams to mitigate risks and d...
1 week ago
Senior Specialist, Physical Security Systems & Services - Remote
$95K - $115K *
Optimize physical security applications and operations. Lead system management, support incident response, and enhance security measures across the enterprise. Collaborate with stakeholders to ensure...
1 week ago
$110K - $130K *
Take ownership of a high-performing team in Client Operations, driving service quality and continuous improvement. Collaborate across functions to enhance client experience and operational efficiency...
1 week ago
Principal Researcher, Benchmarks, Evaluation, and Standards
$133K - $197K *
Drive impactful research by leading technical evaluations and benchmarks in AI. Collaborate with diverse stakeholders to ensure principled guidance that integrates social and technical considerations...
1 week ago
Contract Salesforce Developer/Admin
$85K - $109K *
Join us to lead a Salesforce centralization initiative, merging environments and enhancing workflows. Collaborate with stakeholders to create scalable solutions, ensuring a secure and maintainable Sal...
1 week ago
$80K - $95K *
Elevate your marketing career by leading integrated organic campaigns that drive engagement and revenue growth. Collaborate cross-functionally to optimize strategies across social media, email, and ac...
1 week ago
Remote Breast Radiologist - RP Eagle
$250K - $300K *
Partner with us to provide expert breast imaging interpretation in a fully remote setting. Enjoy flexible scheduling and a supportive team environment while contributing to exceptional patient care ac...
1 week ago
AI Infrastructure Consulting Engineer - Converged Compute & Storage
$77K - $108K *
Join a dynamic team to design and implement high-performance AI infrastructure solutions, ensuring client satisfaction through expert delivery and support of complex compute and storage systems for en...
1 week ago
$120K - $135K *
Lead the charge in full-funnel paid social strategy, execution, and optimization for high-growth clients. Collaborate with teams to deliver integrated marketing solutions and drive measurable business...
Reposted 1 week ago
Staff Software Engineer - 340B Check
$170K - $200K *
Lead technical direction for a healthcare data team, driving architectural decisions and cross-team initiatives to enhance compliance and operational efficiency. Elevate team performance while solving...
1 week ago
Senior Data Scientist II, Core & Agentic Automation
$183K - $216K *
Unlock your potential by leading data science initiatives that drive impactful decision-making and enhance analytical frameworks across teams, ensuring rigorous performance standards and scalable self...
1 week ago
Accounting Methods Manager - Remote Eligible
$99K - $169K *
Empower your career by providing expert consulting on accounting methods, managing client projects, and developing staff. Engage with clients and lead technical training while staying updated on tax r...
1 week ago
$88K - $105K *
Champion dealer network growth by leading recruitment and development efforts, collaborating with cross-functional teams to drive strategy and execution, and ensuring best practices for onboarding new...
1 week ago
$155K - $170K *
Lead the charge in architecting scalable Salesforce solutions, driving platform strategy, and ensuring high-quality integrations across KIPP's national ecosystem. Collaborate with stakeholders to deli...
1 week ago
Spend Management Account Executive
$85K - $113K *
Engage with finance leaders to drive growth in our client base, leveraging your FinTech expertise. Collaborate with a dynamic sales team to refine strategies and exceed sales quotas while promoting in...
1 week ago
$66K - $99K *
Champion patient care by utilizing your nursing expertise to lead clinical teams, coordinate care, and mentor staff. Engage in effective communication and critical thinking to enhance patient outcomes...
1 week ago
Director, Nursing and Clinical Services
$100K - $120K *
Lead the charge in delivering high-quality rural healthcare by overseeing nursing and clinical operations. Engage with staff and patients to ensure compliance and enhance patient care standards in a d...
1 week ago
Technical Solutions Manager - Life Sciences
$135K - $160K *
Lead the charge in delivering innovative DCS solutions for Life Sciences. Serve as the technical expert, driving automation strategies and ensuring compliance with regulations to support growth and ex...
Reposted 1 week ago
Sales Development Partner - Entry Level to Leadership
$75K - $100K *
Elevate partnerships with diverse businesses, understanding their needs and delivering tailored solutions while fostering growth and leadership opportunities in a dynamic, field-focused environment...
Reposted 1 week ago
Technical Support Manager, Billing - Remote US, ET or CT
$75K - $100K *
Manage day-to-day billing operations and client support in the energy sector. Lead client interactions, troubleshoot technical issues, and collaborate with internal teams to enhance service delivery a...
1 week ago
$69K - $101K *
Champion the reliability of automated systems by providing expert technical support, troubleshooting complex issues, and collaborating cross-functionally to ensure operational excellence and seamless...
1 week ago
Principal/Sr Principal Supplier Mission Assurance Engineer - 19548
$94K - $141K *
Join a dynamic team to oversee supplier quality assurance, manage compliance, and engage in supplier evaluations. Leverage your expertise to ensure product integrity while collaborating directly with...
Reposted 1 week ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.