Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$180K - $220K *

Drive the engineering vision for innovative nuclear technology, leading a multi-disciplinary team to ensure successful design, execution, and regulatory compliance for groundbreaking reactor systems d...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Energy & Utilities

$80K - $115K *

Optimize client success by managing relationships, driving renewals, and aligning technology with client needs. Collaborate with cross-functional teams to deliver impactful solutions and ensure long-t...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Media

$250K - $500K *

Champion innovation by leading the migration to EKS, optimizing cloud infrastructure, and enhancing Kubernetes operations. Drive automation and CI/CD processes while ensuring high availability and per...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$123K - $160K *

Champion innovative cancer therapies by leading quality operations for apheresis and treatment centers. Collaborate cross-functionally to ensure compliance and support Kite's rapid expansion in CAR-T...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Explore an impactful leadership role driving sales strategies and team development in the PAH marketplace. Collaborate with cross-functional teams to enhance performance and foster relationships with...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$113K - $160K *

Champion the quantification of business impact from technology and transformation investments. Lead financial modeling and value realization efforts, translating insights into actionable recommendatio...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$80K - $95K *

Reimagine operational excellence by leading a regional team to optimize performance, enhance customer satisfaction, and ensure compliance. Drive financial success while fostering a safe and efficient...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Transportation

$113K - $188K *

Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$90K - $120K *

Drive financial excellence by collaborating across teams to enhance planning and reporting processes. This role blends detailed analysis with strategic insight, offering visibility into key leadership...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$250K - $275K *

Champion partner engagement and drive revenue growth by managing established channel relationships. Leverage your expertise in Telecommunications and Unified Communications to enhance partner success...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$70K - $100K *

Join a dynamic team to drive profitable business through strategic underwriting and broker partnerships. Leverage your expertise to enhance client relationships and contribute to innovative solutions...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Unlock your potential as a Product Manager, driving product health and outcomes through strategic decision-making, collaboration, and customer insights across the product lifecycle. Shape the future o...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$160K - $180K *

Unlock potential by leading creative engagements across healthcare accounts. Drive innovative campaigns, mentor teams, and manage client relationships while delivering impactful narratives that resona...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$109K - $156K *

Champion reliability by leading SRE projects from inception to production. Collaborate with teams to enhance infrastructure across hybrid environments, driving architectural excellence and operational...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$95K - $115K *

Champion user experience by enhancing our insurance platform's web interface. Collaborate with teams to simplify design, implement UX initiatives, and develop solutions that empower agents and interna...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$105K - $155K *

Champion advanced security initiatives by leading Red Team efforts to identify vulnerabilities and enhance protection across enterprise systems through penetration testing and adversarial emulation, w...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$93K - $124K *

Lead the development of compelling cybersecurity narratives and content that connect technology solutions to customer needs. Collaborate across teams to create impactful sales enablement materials and...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Champion innovative AI platform architecture and drive enterprise-level integration of machine learning, ensuring security, accuracy, and reliability across systems while mentoring teams to elevate te...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$115K - $151K *

Grow your career with a dynamic team focused on AI tool administration and governance. Collaborate across departments to enhance system connectivity and process automation while ensuring data privacy...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $190K *

Lead the charge in combating cyber-enabled fraud by investigating complex threats, analyzing digital signals, and collaborating across teams to enhance detection and risk mitigation strategies...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $150K *

Elevate procurement operations by managing vendor coordination, documentation, and process consistency. This role focuses on execution and queue management, ensuring timely and organized procurement s...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Elevate your career by managing technical programs across global engineering teams. Drive alignment, enhance decision-making, and leverage AI to optimize workflows while supporting senior leadership i...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$108K - $140K *

Transform talent acquisition by leading a dynamic recruiting team, driving data-informed strategies, and enhancing candidate experiences to meet organizational growth and workforce needs...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Drive transformative AI initiatives across departments by leading a strategic team in designing scalable, agentic workflows that enhance decision-making and efficiency, ensuring measurable business ou...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$222K - $278K *

Empower businesses by eliminating supply chain blind spots. Drive adoption of our innovative Tracking Label product, collaborating with Enterprise teams to enhance shipment visibility and security acr...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.