Explore South Dakota Jobs Paying $100,000 or More

Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.

Find High-Paying Opportunities Across South Dakota

South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.

Explore South Dakota’s Major Job Markets

Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.

Build Your Next Career Move

Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.

Search South Dakota Jobs on Ladders

Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $121,112

Sort By: Relevance

$109K - $156K *

Champion reliability by leading SRE projects from inception to production. Collaborate with teams to enhance infrastructure across hybrid environments, driving architectural excellence and operational...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$95K - $115K *

Champion user experience by enhancing our insurance platform's web interface. Collaborate with teams to simplify design, implement UX initiatives, and develop solutions that empower agents and interna...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$105K - $155K *

Champion advanced security initiatives by leading Red Team efforts to identify vulnerabilities and enhance protection across enterprise systems through penetration testing and adversarial emulation, w...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$93K - $124K *

Lead the development of compelling cybersecurity narratives and content that connect technology solutions to customer needs. Collaborate across teams to create impactful sales enablement materials and...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$150K - $180K *

Champion innovative AI platform architecture and drive enterprise-level integration of machine learning, ensuring security, accuracy, and reliability across systems while mentoring teams to elevate te...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$115K - $151K *

Grow your career with a dynamic team focused on AI tool administration and governance. Collaborate across departments to enhance system connectivity and process automation while ensuring data privacy...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $190K *

Lead the charge in combating cyber-enabled fraud by investigating complex threats, analyzing digital signals, and collaborating across teams to enhance detection and risk mitigation strategies...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $150K *

Elevate procurement operations by managing vendor coordination, documentation, and process consistency. This role focuses on execution and queue management, ensuring timely and organized procurement s...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Elevate your career by managing technical programs across global engineering teams. Drive alignment, enhance decision-making, and leverage AI to optimize workflows while supporting senior leadership i...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$108K - $140K *

Transform talent acquisition by leading a dynamic recruiting team, driving data-informed strategies, and enhancing candidate experiences to meet organizational growth and workforce needs...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Drive transformative AI initiatives across departments by leading a strategic team in designing scalable, agentic workflows that enhance decision-making and efficiency, ensuring measurable business ou...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$222K - $278K *

Empower businesses by eliminating supply chain blind spots. Drive adoption of our innovative Tracking Label product, collaborating with Enterprise teams to enhance shipment visibility and security acr...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $200K *

Drive the evolution of Sales Operations by designing and optimizing processes, governance, and technology to enhance execution and productivity across the organization, ensuring alignment with strateg...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $155K *

Empower targeted marketing initiatives that drive engagement and revenue growth. Collaborate with Sales and Product teams to create personalized strategies, leveraging insights and AI tools to enhance...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $110K *

Unlock potential by overseeing clinical trials, ensuring compliance with protocols and regulations. Collaborate with investigators and coordinators to protect participant rights and verify data integr...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $95K *

Accelerate progress at our Third Party Management vertical by engaging in prospecting and sales processes. Collaborate with leadership to define strategies, enrich CRM, and generate opportunities that...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $100K *

Join a team that's focused on driving financial accuracy while managing month-end closes, reconciliations, and cost accounting. Contribute to board-level reporting in a dynamic PE-backed SaaS environm...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$143K - $208K *

Join a dynamic team as you lead enterprise-wide manufacturing strategy, ensuring performance and scalability across multiple facilities while driving cross-functional collaboration and continuous impr...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$68K - $97K *

Unlock potential by delivering innovative designs that elevate brand identity. Collaborate on strategic campaigns, mentor junior designers, and lead complex projects from concept to execution, all whi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$194K - $361K *

Lead the development of innovative NovaOS capabilities, ensuring alignment with business goals and driving continuous improvement through collaboration across cross-functional teams. Deliver measurabl...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Elevate your career by resolving complex commercial property losses, managing national accounts, and providing expert insights. Collaborate with diverse stakeholders while ensuring compliance and main...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$133K - $184K *

Join a team that's enhancing threat detection and response capabilities. As a hands-on technical leader, you'll drive security initiatives across cloud, infrastructure, and identity platforms, while m...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$129K - $210K *

Empower organizations by designing scalable data management solutions, collaborating with customers and partners to drive adoption and success. Act as a key technical advisor, bridging teams to ensure...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$135K - $160K *

Lead the charge in building AI-powered engineering systems that enhance developer workflows, ensuring reliability and ease of adoption for engineers. Collaborate with teams to create innovative soluti...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$132K - $198K *

Elevate quality assurance practices by leading test strategy and execution for customer implementations. Collaborate with teams to enhance product quality, mitigate risks, and establish scalable testi...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What South Dakota jobs on Ladders pay $100,000 or more?question toggle

    Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.

  • Which South Dakota cities have high-paying jobs?question toggle

    Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.

  • Are remote jobs available to South Dakota residents?question toggle

    Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.

  • How can I find senior-level jobs in South Dakota?question toggle

    Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.

  • Does Ladders verify South Dakota job listings?question toggle

    Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.