Discover professional opportunities across South Dakota with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From established employers in Sioux Falls and Rapid City to opportunities in communities throughout the state, South Dakota offers career paths for experienced professionals seeking leadership, specialized expertise, and room to grow.
South Dakota’s economy includes healthcare, financial services, technology, manufacturing, agriculture, energy, and business services. Employers may seek professionals in areas such as executive leadership, operations, finance, sales, engineering, healthcare administration, and information technology. Browse current listings to see which roles and locations match your experience and goals.
Sioux Falls is a major center for healthcare, finance, and corporate services, while Rapid City supports opportunities in healthcare, tourism, government, and regional business. High-paying roles may also be available in smaller cities and communities, including remote or hybrid positions connected to South Dakota employers.
Senior-level searches often reward a focused approach. Highlight measurable accomplishments, leadership experience, specialized credentials, and results relevant to each role. Review compensation details and job requirements, and use Ladders to explore vetted openings that meet the $100,000-and-up salary threshold.
Whether you are already based in South Dakota or considering a move, browse available listings to identify opportunities that align with your skills, preferred location, and career ambitions. New roles can appear over time, so check back regularly for the latest high-paying professional jobs.
Average Salary: $121,112
Director of Business Development
$105K - $115K *
Empower a dynamic sales team to drive revenue growth through strategic partnerships and innovative territory planning. Shape the future of business development by fostering relationships and deliverin...
4 days ago
$95K - $100K *
Join a dynamic team as a Senior Strategist, where you'll lead data-driven strategies, mentor talent, and drive innovative solutions in healthcare advertising. Collaborate with creative teams to enhanc...
4 days ago
Sr Lead, Reliability Engineering
$123K - $169K *
Unlock potential by leading reliability improvement programs across a global network of manufacturing sites and distribution centers. Drive hands-on engineering initiatives, optimize maintenance strat...
4 days ago
Vice President, Commercial Pricing - REMOTE
$210K - $230K *
Lead the charge in developing enterprise pricing strategies that optimize profitability and drive growth across diverse service sectors, ensuring alignment with market conditions and client needs whil...
4 days ago
$110K - $130K *
Elevate your career by developing and optimizing machine learning models, collaborating with cross-functional teams to drive data-driven solutions and enhance predictive analytics in a dynamic, Agile...
4 days ago
$110K - $199K *
Develop and maintain scalable data pipelines, leveraging Snowflake and cloud tools to enhance data quality and accessibility. Mentor a growing team while driving best practices in data engineering and...
Reposted 4 days ago
Growth Design Manager, Web & Acquisition
$120K - $145K *
Lead the charge in web growth design, optimizing top-of-funnel experiences to enhance customer engagement and conversion. Collaborate with cross-functional teams to create compelling, high-quality web...
4 days ago
Commerce Media Strategist, Amazon Search
$80K - $95K *
Take ownership of client-centric commerce media strategies, optimizing campaigns across platforms like Amazon and Walmart. Leverage data insights to drive growth and ensure client satisfaction while c...
4 days ago
Corporate Account Executive - West
$110K - $130K *
Unlock potential by leading the full sales cycle, building executive relationships, and driving business transformation across industries. Collaborate with teams to innovate sales processes and ensure...
4 days ago
Senior Director, Engineering - Proactive Offense
$315K - $370K *
Join a team that's redefining offensive security by leading engineering efforts to transform research into scalable, customer-facing products. Drive strategy, execution, and innovation across multiple...
4 days ago
$90K - $110K *
Unlock potential by leading compliance initiatives and advising leadership on regulatory strategies. This role ensures adherence to laws, mentors staff, and collaborates with stakeholders to mitigate...
4 days ago
$106K - $197K *
Elevate your career by managing complex revenue accounting activities, leading process improvements, and collaborating across teams to enhance scalability and efficiency in a dynamic environment focus...
4 days ago
Supervisory Healthcare Engineer (Deputy)
$85K - $100K *
Unlock potential by leading engineering programs at a dynamic healthcare facility. Collaborate with diverse teams to enhance operations, ensure compliance, and drive strategic initiatives that support...
4 days ago
Director Digital Manufacturing Innovation
$175K - $237K *
Lead the charge in digital manufacturing innovation, transforming operational needs into practical solutions. Collaborate globally to enhance data, AI, and automation capabilities, ensuring safe and e...
4 days ago
$110K - $130K *
Transform aircraft maintenance processes as a B-1 Flight Systems SME, enhancing lifecycle management and logistics support. Collaborate with engineering and logistics teams to ensure mission success a...
4 days ago
12 - Director, Business Development 1
$140K - $195K *
Engage in strategic business development, overseeing global projects and teams. Drive long-term planning, policy formation, and customer negotiations while fostering collaboration with senior manageme...
Reposted 4 days ago
Manager, Product Management - Provider Contracting, Credentialing & Network
$108K - $180K *
Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...
4 days ago
$153K - $290K *
Transform drug discovery by leading a dynamic team in medicinal chemistry, driving innovative small-molecule candidates from concept to IND-ready status while fostering collaboration across a global n...
4 days ago
Senior Director, DMPK Project Leader
$177K - $338K *
Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...
Reposted 4 days ago
Associate Director, Project Management
$117K - $189K *
Pioneer global Orexin development programs by driving project management efforts. Partner with the Global Team Leader to oversee cross-functional teams, manage critical activities, and ensure project...
Reposted 4 days ago
Product Owner - Digital Banking Experience
$80K - $95K *
Unlock potential by leading the digital banking strategy and execution. Collaborate across teams to enhance customer experiences, drive operational efficiency, and support business growth through inno...
Reposted 4 days ago
Configuration Professional II, Contact Center Solutions
$75K - $95K *
Unlock potential by managing Genesys Cloud configurations and ensuring system integrity. Collaborate with teams to implement changes, troubleshoot issues, and maintain documentation for optimal contac...
4 days ago
Director, Production and Infrastructure Engineering
$240K - $290K *
Elevate your career by leading a dynamic engineering team focused on production and infrastructure. Drive performance, foster collaboration, and deliver innovative solutions while managing diverse tec...
4 days ago
$154K - $242K *
Champion operational excellence by leading global tax provisions and compliance. Collaborate with cross-functional teams to enhance processes, mentor talent, and drive strategic tax initiatives while...
4 days ago
Territory Sales Representative, Dental Implants MIS
$82K - $150K *
Accelerate growth by driving new customer acquisition and expanding market share within the dental implant community. Leverage a hunter mentality to convert competitive accounts and position value-ori...
Reposted 4 days ago
What South Dakota jobs on Ladders pay $100,000 or more?
Ladders features vetted professional jobs with salaries of $100,000 or more. South Dakota listings may include senior roles in healthcare, finance, technology, operations, sales, engineering, and executive leadership, depending on current openings.
Which South Dakota cities have high-paying jobs?
Sioux Falls and Rapid City are prominent employment centers, and opportunities may also be available in other South Dakota communities or through remote and hybrid roles. Browse current listings for specific locations.
Are remote jobs available to South Dakota residents?
Some employers advertise remote or hybrid positions that can be performed from South Dakota. Check each listing for its location, residency, and work-arrangement requirements.
How can I find senior-level jobs in South Dakota?
Search South Dakota listings by role, location, and relevant keywords, then review requirements and compensation. Tailor your application to emphasize leadership, specialized expertise, and measurable accomplishments.
Does Ladders verify South Dakota job listings?
Ladders focuses on vetted professional opportunities paying $100,000 or more. Review each posting for employer details, responsibilities, location, and compensation information before applying.