Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$100K - $120K *

Drive the database conversion workstream for a major migration project, overseeing planning, execution, and delivery. Collaborate with teams to optimize performance and ensure successful outcomes in a...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$190K - $225K *

Join a dynamic team to define and execute impactful product strategies that enhance customer solutions in the financial sector. Lead complex partnerships and drive product expansion, shaping the futur...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $151K *

Administer and enhance collaboration platforms, ensuring seamless integration and automation across teams. Collaborate with cross-functional departments to optimize workflows and improve operational e...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $162K *

Transform the suitability review process by leading a dynamic team focused on compliance, operational excellence, and continuous improvement. Collaborate across functions to ensure timely, accurate re...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Join a team that's redefining power delivery solutions by engaging with customers to translate complex power architecture into innovative connector and cable designs, ensuring alignment between engine...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Join a team that's shaping the future of interconnect technology by designing innovative connector solutions. Leverage your engineering expertise to collaborate globally and meet the demands of leadin...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$146K - $225K *

Unlock potential by owning the operational health of technical accounts, driving integrations, and collaborating across teams to deliver exceptional service and solutions that align with merchant obje...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$94K - $135K *

Shape the future of implementation by leading a dynamic team to ensure successful project execution, stakeholder engagement, and quality outcomes in a fast-paced environment...

United StatesRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$100K - $150K *

Transform patient care by leveraging multimodal AI models in a hands-on role. Collaborate with life sciences to innovate solutions, ensuring regulatory compliance while contributing to impactful resea...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Champion the adoption of MRD testing services by engaging clinicians and stakeholders, driving strategic business development, and maximizing client relationships within major cancer centers and healt...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$102K - $134K *

Join a team that's redefining project estimating by leading the preparation of competitive bids and cost analyses for electrical construction projects. Collaborate with estimators and suppliers to ens...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$80K - $100K *

Support a diverse team in delivering exceptional field service for high-tech vacuum products. Engage with customers, troubleshoot systems, and ensure operational excellence while traveling for install...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$128K - $225K *

Unlock potential by leading cloud engineering strategy and product development. Oversee a high-performing team to deliver secure, scalable cloud solutions across multiple providers, ensuring alignment...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$71K - $118K *

Advance your career by analyzing and responding to cyber incidents in a dynamic 24x7 Security Operations Center, supporting U.S. State, Local, Tribal, and Territorial governments with critical securit...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$131K - $209K *

Engage with teams to deliver comprehensive AI enablement programs, designing tailored learning paths and fostering a culture of proficiency across all departments. Collaborate closely with HR to integ...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Elevate HR leadership by driving people strategies that enhance organizational effectiveness and employee engagement across multiple locations in the North America Industrial & Construction sector, pa...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Transportation

$135K - $160K *

Lead the charge in building a unified technical organization that enhances customer experience through application support and field service, driving project conversions and fostering a culture of con...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$189K - $255K *

Drive strategic sales initiatives by developing account plans, fostering C-level relationships, and leading negotiations to maximize customer success and revenue growth across a diverse product portfo...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Accelerate client relationships by managing strategic accounts, driving revenue growth, and expanding service lines. Collaborate with internal teams to ensure client satisfaction and deliver tailored...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$125K - $150K *

Accelerate account management strategy and execution for premier accounts. Strengthen relationships through planning, product penetration, and high-quality execution while collaborating across teams t...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$105K - $163K *

Empower AI seeks to optimize ITSM solutions by leading ServiceNow development for a Department of War agency. Drive high-quality, secure applications while enhancing user experience through Agile meth...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $160K *

Unlock potential by leading strategic capture efforts for federal opportunities. Drive business development initiatives, engage with customers and partners, and coordinate cross-functional teams to se...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $130K *

Join our dynamic sales team to drive growth in the rail and transit market. Engage with OEMs and engineering teams, providing tailored connectivity solutions while managing strategic accounts across a...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Drive quality assurance initiatives by overseeing inspections, compliance, and documentation processes. Collaborate with suppliers and clients to ensure adherence to standards and enhance operational...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

$100K - $108K *

Join a dynamic team to provide essential data management and help desk support for public health initiatives, ensuring effective communication and technical assistance for healthcare facilities and us...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.