Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Strategist, Paid Search (DTC)
$85K - $106K *
Empower clients by leading innovative paid search strategies across diverse categories. Collaborate with cross-functional teams to drive performance, optimize campaigns, and connect search tactics to...
3 days ago
$80K - $95K *
Lead the implementation of safety programs across multiple wind and solar project sites, ensuring compliance and promoting a safe work environment for all team members and contractors. Collaborate wit...
Reposted 3 days ago
Territory Manager - Glaucoma - Central
$90K - $140K *
Unlock potential by driving growth and adoption of innovative surgical glaucoma technology. Collaborate with surgeons and staff to deliver exceptional support and education, while building sustainable...
Reposted 3 days ago
21GRAMS- Creative Director, Copy
$200K - $220K *
Drive impactful healthcare advertising by leading creative teams, overseeing brand strategies, and ensuring high-quality copy and art execution. Collaborate across departments to foster innovation and...
3 days ago
Commercial Casualty Supervisor, Complex Claims - Remote
$110K - $147K *
Transform complex claims management by supervising 1st and 3rd party auto and commercial injury claims. Lead a remote team, ensuring compliance and operational excellence while fostering strong relati...
3 days ago
VP OF SALES - EAST COAST - HEALTHCARE
$160K - $200K *
Empower your career by leading a high-performing sales team to drive profitable growth in the healthcare sector. Develop and execute strategic sales initiatives, foster client relationships, and ensur...
Reposted 3 days ago
Senior Account Executive II, Federal DOW/Army/Navy/Air Force/Pentagon
$140K - $175K *
Transform your career by engaging with federal clients, driving enterprise solutions, and building lasting relationships in a dynamic SaaS environment. Leverage your technical expertise to exceed sale...
3 days ago
$180K - $220K *
Optimize revenue and profitability as you lead commercial finance, drive pricing strategies, and negotiate pivotal agreements with stakeholders, playing a vital role in shaping financial success acros...
Reposted 3 days ago
Senior Engineering Manager - GTM
$239K - $298K *
Discover a pivotal role in shaping the future of our engineering function. Lead a small team to enhance our GTM engine, integrating product and marketing efforts while driving innovation in technology...
3 days ago
Division Vice President IT and Digital Transformation- Aerospace & Defense Division
$225K - $250K *
Lead the charge in pioneering technology strategies that enhance operational excellence and drive innovation across multiple business units. Partner with leaders to implement advanced solutions in AI...
Reposted 3 days ago
$110K - $145K *
Partner with us to drive sales growth and elevate client relationships. Utilize tailored product demos and consultative techniques to enhance customer satisfaction and revenue, while leveraging your e...
Reposted 3 days ago
$125K - $150K *
Join a team that's building the Keycard Agent SDK to empower developers by enhancing trust, governance, and telemetry for AI agents. Collaborate on innovative solutions across multiple languages and f...
Reposted 3 days ago
$139K - $235K *
Lead the charge in transforming investor relations processes, enhancing communication of strategy and performance to the market. Collaborate with executives to manage investor relationships and delive...
3 days ago
$222K - $278K *
Join a dynamic team to drive enterprise sales, transforming industries through innovative technology. Engage with C-level executives, manage complex deals, and foster lasting relationships to enhance...
3 days ago
Sales Account Executive (US-remote)
$160K - $180K *
Elevate your career by driving sales in the U.S. healthcare market, engaging diverse stakeholders, and managing complex sales cycles to expand our national brain-network footprint through strategic pa...
3 days ago
$100K - $300K *
Lead complex analytical initiatives by developing data solutions and dashboards that drive business insights. Collaborate with stakeholders to translate requirements into scalable analytical framework...
3 days ago
$190K - $220K *
Champion innovation and execution as you lead product management across diverse e-commerce channels. Drive strategic roadmaps, manage global teams, and deliver cutting-edge solutions that enhance cust...
3 days ago
$115K - $150K *
Innovate at the forefront of database management, ensuring performance, reliability, and security in a high-volume SQL Server environment. Lead incident response and engineering solutions to enhance o...
Reposted 3 days ago
Director, Executive Compensation
$156K - $227K *
Elevate executive compensation strategies by designing and leading Total Rewards programs that align with organizational goals, while collaborating with key stakeholders to ensure compliance and effec...
3 days ago
$120K - $160K *
Unlock potential by leading complex cyber investigations, mentoring junior analysts, and analyzing sophisticated threats to safeguard AI systems from misuse. Drive impactful decisions and enhance safe...
3 days ago
Manager, Industrial Controls Engineering
$144K - $211K *
Drive engineering excellence by leading a high-performing team in implementing and scaling industrial control systems. Collaborate across functions to ensure reliable, maintainable solutions that supp...
3 days ago
Commissioning Senior Project Manager
$120K - $160K *
Engineer the future of critical facility commissioning by leading project teams, managing schedules, and ensuring compliance with design and safety standards. Drive successful project execution throug...
3 days ago
SAP Business AI Lead Architect
$160K - $229K *
Lead the design and development of AI-driven solutions within SAP S/4HANA, integrating advanced AI technologies to drive business transformation and innovation across enterprise environments. Mentor t...
3 days ago
Account Manager, Client Development & Renewals (Texas)
$123K - $135K *
Engage with existing customer accounts to drive renewal retention and expansion revenue. This growth-focused role emphasizes consultative upselling and cross-selling, ensuring customer satisfaction wh...
3 days ago
Bioinformatics Application Scientist, NGS - AMER
$125K - $141K *
Join a team that's dedicated to providing expert bioinformatics support, bridging customer needs with innovative NGS solutions. You'll play a key role in pre- and post-sales activities, ensuring custo...
3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.