Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$100K - $120K *

Advance healthcare solutions by driving sales of innovative diagnostic instruments. Engage with key stakeholders to promote QIAstat-Dx systems, ensuring successful adoption and customer satisfaction t...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$190K - $214K *

Lead HCP personal promotion strategy, developing and optimizing initiatives that engage healthcare professionals. Collaborate cross-functionally to ensure compliance and effectiveness in promotional t...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $225K *

Lead the charge in transforming AI strategies into impactful solutions for revenue teams, collaborating closely with GTM leaders to drive innovation and measurable outcomes while enhancing engineering...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $180K *

Elevate healthcare creativity by leading innovative campaigns that transform client brands. Collaborate with teams to deliver impactful experiences across digital channels, leveraging insights and eme...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a team that's redefining cloud solutions by architecting and delivering complex Azure engagements. Lead migrations, mentor engineers, and drive innovation while ensuring robust security and gover...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $112K *

Join a team that's transforming customer engagement through innovative product launches. You'll lead cross-functional collaboration, develop training materials, and ensure readiness for market, all wh...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Join the forefront of quality assurance in government logistics. Lead the development and enhancement of a robust Quality Management System across multiple sites, ensuring compliance and operational e...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$76K - $124K *

Engage in foundational sales support, collaborating with Client Account Executives to develop skills in territory strategy, deal mechanics, and enterprise sales, while preparing for a quota-carrying r...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Shape the future of automotive sales by leading a dynamic team, developing strategic initiatives, and engaging directly with clients to enhance their repair processes while achieving ambitious sales t...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$150K - $200K *

Bring your expertise to lead sales strategies and customer development across NCC and VIS product lines, driving profitable growth and enhancing commercial processes while fostering collaboration with...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$79K - $109K *

Transform financial operations by owning monthly close processes, ensuring accurate COGS and accruals. Collaborate with leadership to drive data-driven decisions in a dynamic, growth-stage tech enviro...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$124K - $171K *

Accelerate sales growth by managing and qualifying strategic Enterprise Intelligence opportunities. Collaborate with cross-functional teams, ensuring comprehensive engagement and communication to opti...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$115K - $151K *

Advance your career by leading financial reporting and forecasting efforts. Collaborate across departments to analyze data, streamline processes, and support strategic planning in a dynamic, high-grow...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Drive revenue cycle operations by managing processes from entry to adjudication. Lead teams, implement efficiencies, and ensure compliance while optimizing cash collections and performance metrics for...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$138K - $165K *

Drive GitLab's Secret Detection and Vulnerability Research efforts to shape security product outcomes. Own the detection lifecycle, ensure content quality, and leverage AI to enhance operational effic...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$112K - $119K *

Unlock new demand by leading our growth marketing strategy through innovative content and partnerships. Collaborate with clinical experts to engage educators and drive product signups across multiple...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Drive innovation in power systems architecture by collaborating with hyperscalers and partners to develop cutting-edge connector and cable solutions. Lead technical programs, influence strategic objec...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$81K - $87K *

Join us to lead and support a dedicated team in delivering exceptional medical services. Oversee case management, coordinate healthcare access, and empower individuals to achieve their health goals wh...

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$210K - $250K *

Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$173K - $255K *

Drive innovation in AI systems by designing and building scalable backend solutions, ensuring security and governance while enhancing developer productivity and operational health across diverse workl...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$112K - $140K *

Transform product quality management by leading complaint intake, investigation, and resolution processes. Collaborate with cross-functional teams to ensure compliance and enhance patient safety while...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $150K *

Lead the charge in enhancing sales performance through targeted enablement initiatives. You'll work closely with diverse sales teams to coach, train, and build effective tools, ensuring impactful and...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$82K - $150K *

Accelerate growth by driving new customer acquisition and expanding market share in the dental implant sector. Leverage a hunter mentality to convert competitive accounts and position value-oriented s...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $220K *

Oversee a specialized team to ensure AI safety in biological research, addressing dual-use risks and providing expert guidance on complex cases while mentoring junior specialists and advising clients...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Elevate brand visibility and engagement by managing PR agency partnerships, developing internal communications strategies, and ensuring consistent messaging across channels to strengthen organizationa...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.