Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$100K - $120K *
Engage with new business opportunities to drive growth and market share in the South-Central U.S. Collaborate with teams to launch solutions, manage customer relationships, and achieve sales targets w...
2 days ago
Director of Business Development
$105K - $115K *
Empower a dynamic sales team to drive revenue growth through strategic partnerships and innovative territory planning. Shape the future of business development by fostering relationships and deliverin...
2 days ago
$95K - $100K *
Join a dynamic team as a Senior Strategist, where you'll lead data-driven strategies, mentor talent, and drive innovative solutions in healthcare advertising. Collaborate with creative teams to enhanc...
2 days ago
Sr Lead, Reliability Engineering
$123K - $169K *
Unlock potential by leading reliability improvement programs across a global network of manufacturing sites and distribution centers. Drive hands-on engineering initiatives, optimize maintenance strat...
2 days ago
Vice President, Commercial Pricing - REMOTE
$210K - $230K *
Lead the charge in developing enterprise pricing strategies that optimize profitability and drive growth across diverse service sectors, ensuring alignment with market conditions and client needs whil...
2 days ago
Senior Partner Marketing Manager
$120K - $160K *
Unlock potential by leading partner marketing initiatives that drive revenue growth. Collaborate with channel sales and strategic partners to create impactful campaigns, enhance partner engagement, an...
2 days ago
$110K - $130K *
Elevate your career by developing and optimizing machine learning models, collaborating with cross-functional teams to drive data-driven solutions and enhance predictive analytics in a dynamic, Agile...
2 days ago
$110K - $199K *
Develop and maintain scalable data pipelines, leveraging Snowflake and cloud tools to enhance data quality and accessibility. Mentor a growing team while driving best practices in data engineering and...
Reposted 2 days ago
Growth Design Manager, Web & Acquisition
$120K - $145K *
Lead the charge in web growth design, optimizing top-of-funnel experiences to enhance customer engagement and conversion. Collaborate with cross-functional teams to create compelling, high-quality web...
2 days ago
Commerce Media Strategist, Amazon Search
$80K - $95K *
Take ownership of client-centric commerce media strategies, optimizing campaigns across platforms like Amazon and Walmart. Leverage data insights to drive growth and ensure client satisfaction while c...
2 days ago
Corporate Account Executive - West
$110K - $130K *
Unlock potential by leading the full sales cycle, building executive relationships, and driving business transformation across industries. Collaborate with teams to innovate sales processes and ensure...
2 days ago
Senior Director, Engineering - Proactive Offense
$315K - $370K *
Join a team that's redefining offensive security by leading engineering efforts to transform research into scalable, customer-facing products. Drive strategy, execution, and innovation across multiple...
2 days ago
$90K - $110K *
Unlock potential by leading compliance initiatives and advising leadership on regulatory strategies. This role ensures adherence to laws, mentors staff, and collaborates with stakeholders to mitigate...
2 days ago
$106K - $197K *
Elevate your career by managing complex revenue accounting activities, leading process improvements, and collaborating across teams to enhance scalability and efficiency in a dynamic environment focus...
2 days ago
Supervisory Healthcare Engineer (Deputy)
$85K - $100K *
Unlock potential by leading engineering programs at a dynamic healthcare facility. Collaborate with diverse teams to enhance operations, ensure compliance, and drive strategic initiatives that support...
2 days ago
Director Digital Manufacturing Innovation
$175K - $237K *
Lead the charge in digital manufacturing innovation, transforming operational needs into practical solutions. Collaborate globally to enhance data, AI, and automation capabilities, ensuring safe and e...
2 days ago
$110K - $130K *
Transform aircraft maintenance processes as a B-1 Flight Systems SME, enhancing lifecycle management and logistics support. Collaborate with engineering and logistics teams to ensure mission success a...
2 days ago
12 - Director, Business Development 1
$140K - $195K *
Engage in strategic business development, overseeing global projects and teams. Drive long-term planning, policy formation, and customer negotiations while fostering collaboration with senior manageme...
Reposted 2 days ago
Manager, Product Management - Provider Contracting, Credentialing & Network
$108K - $180K *
Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...
2 days ago
$153K - $290K *
Transform drug discovery by leading a dynamic team in medicinal chemistry, driving innovative small-molecule candidates from concept to IND-ready status while fostering collaboration across a global n...
2 days ago
Senior Director, DMPK Project Leader
$177K - $338K *
Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...
Reposted 2 days ago
Associate Director, Project Management
$117K - $189K *
Pioneer global Orexin development programs by driving project management efforts. Partner with the Global Team Leader to oversee cross-functional teams, manage critical activities, and ensure project...
Reposted 2 days ago
Product Owner - Digital Banking Experience
$80K - $95K *
Unlock potential by leading the digital banking strategy and execution. Collaborate across teams to enhance customer experiences, drive operational efficiency, and support business growth through inno...
Reposted 2 days ago
Configuration Professional II, Contact Center Solutions
$75K - $95K *
Unlock potential by managing Genesys Cloud configurations and ensuring system integrity. Collaborate with teams to implement changes, troubleshoot issues, and maintain documentation for optimal contac...
2 days ago
Director, Production and Infrastructure Engineering
$240K - $290K *
Elevate your career by leading a dynamic engineering team focused on production and infrastructure. Drive performance, foster collaboration, and deliver innovative solutions while managing diverse tec...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.