Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $122,395

Sort By: Relevance

$80K - $95K *

Lead the charge in neurodiagnostic services, overseeing operations, guiding staff, and ensuring high-quality patient care while collaborating with healthcare professionals to enhance service delivery...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Optimize patient outcomes by collaborating with healthcare teams to provide expert oncology pharmacotherapy, ensuring safe medication management and education across multiple pharmacy locations with a...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$130K - $140K *

Elevate your career by joining a dynamic team to design and implement innovative cloud solutions in a multi-cloud environment, ensuring scalability, security, and alignment with business objectives wh...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$162K - $203K *

Champion scientific engagement by building relationships with key opinion leaders in Urology and Women's Health. Leverage expertise to support medical strategies and enhance product knowledge across t...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Elevate employee experiences by designing and implementing HR solutions. Lead technical projects, optimize integrations with Microsoft 365, and mentor developers to enhance ServiceNow capabilities and...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $95K *

Accelerate progress at drug development by leading bioanalytical studies, optimizing methods, interpreting data, and collaborating with teams to enhance innovative therapies for patients...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower patient care by ensuring safe and effective drug therapy through accurate dispensing, monitoring, and education, while collaborating with healthcare providers to enhance pharmacotherapy practi...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Champion the growth of our commercial engine by leading business development efforts, forging strategic partnerships, and driving revenue as quantum computing transitions to enterprise applications. C...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $185K *

Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$115K - $140K *

Drive operational excellence in commercial readiness and support cross-functional teams to ensure effective execution of launch strategies and operational priorities in a dynamic biotech environment...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$225K - $275K *

Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$132K - $207K *

Elevate your career by driving growth in the mortgage industry, partnering with top lenders to enhance FICO's analytics solutions. Lead strategic initiatives, foster client relationships, and deliver...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$200K - $225K *

Transform marketing strategies to drive growth and engagement across public and private sectors. Lead integrated marketing efforts, brand positioning, and customer marketing services while leveraging...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$157K - $256K *

Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Drive strategic sourcing initiatives by leading supplier negotiations and managing relationships globally. Shape category strategies to optimize cost, quality, and delivery performance while ensuring...

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Empower decision-making by transforming spend data into actionable insights. In this role, you'll develop dashboards, analyze procurement data, and collaborate with teams to enhance visibility and dri...

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Transform sourcing operations by leveraging AI and automation tools. Collaborate with teams to enhance workflows, enforce governance, and drive efficiency through innovative solutions, ensuring compli...

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $182K *

Accelerate growth by driving new software sales, building client relationships, and tailoring solutions to meet unique business needs. Collaborate with cross-functional teams to ensure a seamless cust...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Accelerate project delivery by managing construction activities, ensuring budget adherence, and maintaining client communication. Oversee multiple commercial refrigeration projects while fostering tea...

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K - $119K *

Lead the evaluation, design, and rehabilitation of bridge structures, ensuring compliance with design codes while collaborating with a dynamic team to deliver innovative solutions and enhance transpor...

5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$85K - $105K *

Optimize regulatory compliance processes for a multi-state transportation network. Collaborate cross-functionally to ensure operational readiness and manage ongoing compliance across diverse markets...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$152K - $221K *

Shape the future of product innovation by leading cross-functional teams to develop and enhance solutions that meet customer needs, drive satisfaction, and align with organizational goals in a dynamic...

5 days ago

  •   5 - 7 years exp.  •   Business Services

$168K - $210K *

Transform pricing strategies by leading cross-functional teams to enhance decision-making and model deployment. Drive the evolution of pricing platforms, integrating advanced AI to streamline workflow...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $150K *

Elevate your career by driving enterprise sales for innovative solutions. Engage with multinational accounts, build strategic relationships, and lead complex negotiations to unlock growth opportunitie...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$90K - $110K *

Join a team that's dedicated to delivering exceptional project implementations and enhancements for restaurant brands. Lead cross-functional efforts, ensuring customer satisfaction while managing time...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.