Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $122,395

Sort By: Relevance

$150K - $180K *

Empower business growth by building strategic relationships and originating multifamily loans. Utilize your expertise to manage the loan process, advise clients, and enhance community presence in the...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$99K - $232K *

Shape the future of banking by leading core platform transformations, optimizing client operations, and delivering innovative solutions that drive strategic success. Foster team growth through mentori...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$130K - $155K *

Lead cross-functional teams to drive enterprise modernization through AI solutions. Oversee complex implementations, ensuring alignment across technical and business stakeholders while delivering meas...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Champion the design and configuration of Ellucian Colleague Financial Aid systems, ensuring alignment with client strategies while providing expert technical support and training to enhance operationa...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$180K - $220K *

Join a thriving practice to deliver exceptional endodontic care, educate patients on treatment options, and foster team growth in a supportive environment focused on patient comfort and health...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the charge in designing a cutting-edge platform for modern data centers, integrating AI and cloud technologies. Collaborate with cross-functional teams to build a robust, scalable architecture th...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Elevate your career by leading creative development for healthcare brands. Guide teams in crafting compelling, clinically accurate content while mentoring junior writers and collaborating across disci...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Lead clinical trial monitoring efforts, ensuring compliance and quality outcomes. Collaborate with stakeholders to coordinate study activities, maintain documentation, and enhance patient safety while...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $290K *

Contribute to the advancement of cancer therapies by managing analytical development and quality control operations, ensuring compliance with regulatory standards, and collaborating across teams to en...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Shape strategic program execution by leading cross-functional initiatives that drive technology-enabled transformation and measurable business outcomes, partnering with executive teams to align object...

5 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Champion environmental compliance by leading programs that ensure adherence to regulations, support operational risk management, and promote sustainability across diverse locations, safeguarding healt...

5 days ago

  •   Less than 5 years exp.  •   Food & Beverages

$99K - $166K *

Join a dynamic team to manage supplier agreements, ensuring compliance and efficiency in contract administration. Drive governance processes, facilitate stakeholder collaboration, and enhance contract...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$79K - $127K *

Join a dynamic team to advance drug discovery through innovative data analysis, integrating multi-omic data for target evaluation, and leveraging AI/ML in a fast-paced environment focused on Immunolog...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$79K - $127K *

Drive innovation in drug discovery by analyzing multi-omic data, enhancing target evaluation, and supporting immunology initiatives. Collaborate within a diverse team to translate findings into action...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$82K - $193K *

Elevate your career by solving complex power system challenges while mentoring others and enhancing customer experiences in a dynamic, collaborative environment...

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$93K - $123K *

Engage with enterprise customers to drive complex sales opportunities, leveraging technical expertise and industry knowledge to deliver tailored solutions and compelling presentations that demonstrate...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $210K *

Shape the future of corporate law by providing strategic legal counsel on M&A, governance, and compliance for a dynamic multinational company. Collaborate with diverse teams to navigate complex transa...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$105K *

Lead the charge in driving new business sales across K-12 districts, building impactful partnerships and advocating for early literacy solutions. Collaborate with internal teams to maximize outreach a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Shape the future of healthcare operations by leading transformative initiatives, optimizing workflows, and enhancing care management effectiveness through strategic partnerships and data-driven insigh...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$134K - $241K *

Elevate your career by leading cybersecurity initiatives across California and the West Coast. Drive customer engagement, enhance security compliance, and support critical infrastructure sectors while...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$145K - $185K *

Transform account-based marketing strategies into impactful campaigns that drive pipeline growth and revenue. Lead integrated initiatives across multiple channels, ensuring alignment with sales and ma...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$168K - $228K *

Transform global GxP Change Management processes by leading strategy, governance, and continuous improvement initiatives across the product lifecycle, ensuring effective risk-based changes and collabo...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$138K - $188K *

Lead global trade compliance initiatives, ensuring adherence to regulations across multiple jurisdictions. Drive strategic programs for import/export operations, risk management, and partner governanc...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Drive your career with a rewarding role providing comprehensive patient-centered care. Join a dedicated team to diagnose, treat, and manage diverse health issues while ensuring adherence to clinical g...

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Engineer critical electrical and mechanical systems for data centers, leading field support, troubleshooting, and reliability improvements while developing operational standards and mentoring teams to...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.