Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Jobs in Pennsylvania

Average Salary in USD

Average Salary: $121,442

Sort By: Relevance

$80K - $100K *

Build lasting relationships by conducting home inspections and closing sales. Leverage your people skills to provide homeowners with trusted pest control solutions, ensuring peace of mind and maximizi...

Today

  •   Less than 5 years exp.  •   Staffing

$225K - $265K *

Shape the future of oncology by leading clinical studies in early-phase development. Collaborate with multidisciplinary teams to drive innovative therapies and ensure high-quality execution of clinica...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$118K - $219K *

Join us in shaping the future of reentry systems as a Loads & Dynamics Analyst. Lead innovative structural-dynamic analyses, influence program strategies, and ensure industry standards while collabora...

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$166K - $309K *

Lead and inspire a dynamic team of software engineers, driving agile project execution and technical excellence while managing recruitment, performance, and career development within a high-stakes env...

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$143K - $252K *

Help us drive digital transformation in the utility sector by building relationships and creating opportunities for innovative solutions that enhance grid operations and customer value across the Nort...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$143K - $252K *

Engage with electric utilities to drive digital solutions, enhancing grid operations and customer relationships. Leverage your consultative sales skills to identify needs and develop innovative soluti...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Lead the charge in optimizing fleet maintenance operations through strategic planning, data governance, and innovative automation. Drive results by enhancing system integration and building strong par...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$110K - $130K *

Champion impactful HCP marketing initiatives for a specialty respiratory biologic. Collaborate with cross-functional teams to drive growth in a competitive market, leveraging insights and innovative s...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$137K - $221K *

Empower innovation by designing and implementing core platform services for agent execution. Collaborate with cross-functional teams to build reliable APIs and workflows, ensuring robust performance a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$210K - $250K *

Lead the transformation of data and AI into business value, driving strategy, governance, and adoption across the organization. Collaborate with stakeholders to enhance analytics maturity and build a...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Finance & Insurance

$100K - $120K *

Transform payment strategies by analyzing interchange and routing data to optimize costs and enhance performance. Leverage advanced analytics and automation to deliver actionable insights for stakehol...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$78K - $101K *

Champion employee safety and health initiatives by managing occupational safety and industrial hygiene programs. Collaborate with stakeholders to mitigate risks and ensure regulatory compliance, while...

Reposted today

  •   Less than 5 years exp.  •   Transportation

$79K - $116K *

Optimize project delivery by supporting large-scale warehouse automation deployments. Engage with cross-functional teams to track deliverables, manage risks, and maintain schedules, ensuring successfu...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Optimize cybersecurity operations by designing and implementing integrations and automation solutions. Collaborate with cross-functional teams to enhance security platforms, improve incident response...

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Unlock potential by leading a dynamic team in industrial chemicals and water services, ensuring compliance, optimizing infrastructure, and driving sustainability initiatives in a technology-driven man...

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$67K - $102K *

Empower multidisciplinary design projects by providing technical leadership and coordination. Ensure compliance with specifications and quality objectives while managing engineering activities through...

Reposted today

  •   5 - 7 years exp.  •   Technical Services

$145K - $169K *

Transform the South Zone's beverage landscape by driving strategic growth, aligning stakeholders, and executing innovative plans that enhance market performance and profitability across a diverse Coca...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Food & Beverages

$232K - $320K *

Unlock potential by leading a dynamic Solutions Consulting team to deliver innovative cybersecurity solutions. Collaborate with sales and customers to ensure value realization and drive success in pre...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the charge in quality assurance as a key supervisor for QA inspection services, overseeing transportation projects in structural steel fabrication and ensuring compliance with DOT standards and s...

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Lead the design and delivery of impactful training programs, creating engaging learning materials and facilitating sessions to enhance employee skills and knowledge across various business units. Driv...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Empower your career by leading the Information Assurance program for critical Army systems. Oversee compliance, manage security processes, and collaborate with stakeholders to ensure robust cybersecur...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$325K *

Transform healthcare by providing medical leadership and oversight in psychiatric services, ensuring quality, safety, and compliance while fostering staff development and enhancing patient care in an...

Today

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Elevate organizational effectiveness by leading HR strategies that align talent, culture, and business objectives. Drive change management and succession planning while fostering a high-performance en...

Today

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$83K - $166K *

Join a dynamic team focused on driving growth in heart failure solutions through impactful sales strategies and consultative insights, while collaborating with key stakeholders to enhance patient care...

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join our team as a strategic partner in compensation analysis and job architecture. You'll enhance compensation programs through data-driven insights and process improvements, supporting critical tale...

Today

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.