Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$120K - $145K *

Engage healthcare professionals and thought leaders by driving scientific discussions, supporting clinical research, and facilitating impactful medical strategies in the rare disease liver portfolio w...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$153K - $290K *

Transform drug discovery by leading a dynamic team in medicinal chemistry, driving innovative small-molecule candidates from concept to IND-ready status while fostering collaboration across a global n...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$88K - $149K *

Join a dynamic team in evaluating medication prior authorizations while developing clinical criteria and working closely with healthcare providers to ensure quality patient care through evidence-based...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $115K *

Champion new client acquisition and expand partnerships in maternal health. Manage the full sales cycle, navigate complex decision-making, and drive revenue growth while collaborating with cross-funct...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $124K *

Lead and optimize research intern activities, ensuring alignment with project goals and technical standards. Manage workflows, provide coaching, and conduct hands-on research while supporting the Dire...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$272K - $340K *

Join a team that's driving CMC strategy and execution for innovative therapies. Lead cross-functional efforts in drug and device development, ensuring compliance and operational excellence from clinic...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$163K - $220K *

Shape the future of healthcare by leading analytics for managed care, driving payer strategies, and delivering insights to enhance access to medical benefit products. Collaborate with cross-functional...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$193K - $308K *

Join a team that's redefining statistical leadership in clinical research. Drive innovative study designs, enhance drug development effectiveness, and influence critical decisions through data-driven...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$116K - $157K *

Lead innovative safety strategies in pharmacovigilance, collaborating with cross-functional teams to ensure patient safety throughout the product lifecycle, from development to post-marketing, while m...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Accelerate client success by owning the onboarding and rollout for enterprise clients, ensuring smooth transitions from purchase to sustained usage. Collaborate with cross-functional teams to drive ad...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$97K - $125K *

Drive impactful change by analyzing user needs and defining requirements for clinical applications. Collaborate with diverse teams to enhance electronic health record systems, ensuring effective docum...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$104K - $143K *

Shape the future of pharmacy software by leading product strategy, managing cross-functional teams, and driving improvements in patient outcomes and business results through innovative product managem...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Join us to empower community coalitions in preventing youth substance use. As a Project Officer, you'll manage grants, provide technical assistance, and enhance local capacities, all while collaborati...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$97K - $145K *

Lead strategic client coding integration initiatives, ensuring alignment with corporate objectives and regulatory compliance while driving operational excellence and innovation across the revenue cycl...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Empower our analyst relations program by managing evaluations, timelines, and coordination. Collaborate with stakeholders to ensure accurate, timely engagement and support market insights for strategi...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$114K - $171K *

Join a team that's driving growth in clinical trials by identifying and securing partnerships. Collaborate with cross-functional leaders to enhance visibility and expand opportunities, ensuring seamle...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$312K - $402K *

Lead the global product strategy from concept to launch, ensuring cross-functional alignment and maximizing asset value throughout its lifecycle. Collaborate with diverse teams to drive successful com...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$165K - $205K *

Lead the charge in cybersecurity governance and risk management consulting. Drive client engagements, develop security frameworks, and mentor teams while ensuring alignment with industry standards and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $165K *

Elevate your career by driving clinical education and training for GI Ultrasound. Collaborate with sales and customers to enhance technical competencies, optimize workflows, and improve patient care t...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$180K - $215K *

Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Leverage strong business acumen and collaborative skills to achieve sale...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Pioneer a high-performing culture by partnering with leaders to deliver strategic HR solutions that enhance employee engagement, retention, and growth in a dynamic, mission-driven environment...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$155K - $175K *

Champion the field as a Medical Science Liaison, driving prelaunch strategies and fostering relationships with key stakeholders. Leverage clinical insights to educate and influence healthcare professi...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$69K - $125K *

Lead the charge in crafting high-quality proposals and managing complex RFP processes while ensuring alignment with customer specifications and company standards under tight deadlines...

United StatesRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Healthcare

$299K - $369K *

Unlock your career potential by driving strategic medical partnerships with US health systems in oncology. Collaborate across functions to enhance evidence generation and meet healthcare priorities th...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$222K - $356K *

Unlock your potential as a Senior Safety Physician, leading safety oversight for late-stage CNS clinical development. Collaborate with cross-functional teams to drive risk management and regulatory su...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.