Welcome to Principal Scientist Jobs

At Ladders, we host an extensive range of high-paying Principal Scientist roles across diverse industries. These positions typically require individuals with a robust understanding of scientific principles along with strong technical and leadership skills.

Who Is a Principal Scientist?

A Principal Scientist is a professional who manages large projects or multiple projects while maintaining high standards of scientific or technical knowledge in their respective field.

What Do They Do?

Principal scientists actively contribute to product development and guide the scientific team towards achieving the organization's objectives. They often also have responsibilities in mentoring, project management, and business development.

Opportunities

Whether you're seeking career advancement or looking to diversify your scientific experience, our platform allows you to explore a variety of job postings from leading companies searching for Principal Scientists.

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$191K - $287K *

Seeking an innovative and accomplished Principal Scientist to join a team developing game-changing analytical instrumentation and assays. Requires Ph.D. with 10+ years of relevant experience in new pr...

More than 4w ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$123K - $173K *

Seeking a Principal Scientist to lead the development of lithium metal anodes in all-solid-state batteries, collaborating with various R&D teams to commercialize high-energy solid-state batteries...

2w ago

  •   8 - 10 years exp.  •   Energy & Utilities

$112K - $169K *

Join the Molecular & Cellular Sciences team at Novartis to develop and validate innovative biomarker solutions for early phase human clinical trials.

6d ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$121K - $161K *

Contribute to research and development of next-generation DC distribution protection and control technologies for buildings and power distribution systems at ABB's Raleigh, NC facility...

More than 4w ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$121K - $181K *

Principal Scientist role at Galois involving driving a research agenda, developing R&D opportunities, and engaging with customers to build safe, reliable, and trustworthy systems...

3w ago

  •     Pharmaceuticals & Biotech

$169K - $233K *

Principal Scientist at Bio-Rad focusing on designing, developing, and supporting life science products. Requires Ph.D. in life science discipline and 10+ years of industry experience...

2w ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$121K - $181K *

Principal Scientist position at PerkinElmer in Woodbridge, Canada, focusing on hands-on research and development of chromatography equipment, leading collaborative projects, and influencing the scient...

New Canada, NSIn-Person

4w ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $195K *

Principal Scientist position at ARA in Littleton, Colorado, requiring experience in areas such as Hypersonics, Directed Energy, Space, and Advanced Technology Development. Responsibilities include dev...

5d ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$130K - $195K *

Principal Scientist specializing in shape memory polymers, leading exploratory research to develop new products and materials in the field of eye care...

2w ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $195K *

Seeking a Principal Scientist in Discovery Biology with expertise in Neuro-Immunology and drug discovery. Responsible for leading cross-functional teams, proposing and evaluating novel targets, and in...

More than 4w ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $195K *

Seeking a biologist enthusiastic about developing functional screens and in vitro mechanism-of-action assays, with an emphasis on neuroscience and neurodegenerative diseases. Responsibilities include...

More than 4w ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $210K *

Seeking a Principal Scientist, Scientific Affairs to provide scientific and strategic guidance for the development and growth of an advanced cell therapy manufacturing platform. Responsible for engagi...

2w ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $195K *

The Principal Scientist at Alkermes provides technical leadership in small molecule analytical methodologies, collaborating with internal and external teams to drive drug development and commercializa...

More than 4w ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$131K - $181K *

Lead the development and deployment of computational methods for NGS-based clinical diagnostic assays in a multidisciplinary team. Requires deep understanding of genomics, cancer biology, and computat...

1w ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $173K *

The Principal Scientist, Process Development at Catalent Biologics is responsible for leading downstream process development projects, executing purification experiments, managing client projects, and...

2w ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$149K - $235K *

Seeking an exceptional and experienced scientist to lead biologics discovery, protein production, purification, engineering, and characterization. Key interface with Immunology and other drug discover...

1w ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$97K - $140K *

The Senior Particle Scientist at MSP is responsible for design, development, and technical support related to particle deposition equipment and services for semiconductor surface defect inspection and...

1w ago

  •     Business Services

$130K - $195K *

Seeking a highly skilled AI Scientist/Engineer with expertise in PyTorch to develop, train, and deploy machine learning models in a collaborative environment...

More than 4w ago

  •   Less than 5 years exp.  •   Information Technology

$133K - $282K *

Principal Applied Scientist position at Microsoft Audience Network focusing on machine learning technologies in areas such as NLP, CV, and LLM to enhance ads recommender systems...

1w ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $220K *

Seeking a Senior Scientist/Principal Scientist in Computational Chemistry to lead medicinal chemistry optimization strategies for drug discovery campaigns. Opportunity to develop methods in covalent d...

Yesterday

  •     Pharmaceuticals & Biotech

$109K - $182K *

The Principal Scientist, Clinical Veterinarian at Pfizer will provide high quality veterinary care to diverse species of research animals, support compliance with regulatory requirements, and collabor...

2w ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $200K *

Lead cross-functional project team in building Metabolic Disease therapeutic area pipeline, focusing on obesity and liver diseases. Conceptualize drug discovery strategies using machine learning platf...

1w ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $180K *

Genesis Therapeutics is seeking a Principal Scientist, Computational Biology to perform biological experiments, analyze data, and lead troubleshooting efforts independently. The role requires experien...

2w ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$97K - $140K *

Senior Scientist role in Point of Care Assay Development at Siemens Healthineers, responsible for designing, maintaining, and troubleshooting in-vitro diagnostic products in the Point-of-Care space...

More than 4w ago

  •   5 - 7 years exp.  •   Business Services

$144K - $216K *

Principal Scientist - CADD role at Novartis in Emeryville, CA, involving leveraging CADD expertise to drive compound optimization cycles, develop computational workflows, initiate drug discovery effor...

More than 4w ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What qualifications do I need to become a Principal Scientist?question toggle

    Most Principal Scientist roles require a minimum of a master's degree in a relevant scientific field. However, many employers prefer candidates with a Ph.D. Extensive experience in the field and a background in research are also typical requirements.

  • What salary can I expect as a Principal Scientist?question toggle

    The salary range for a Principal Scientist varies greatly depending on the industry, location, and level of experience. Please refer to individual job listings on our website for specific salary information.

  • What growth opportunities are available for a Principal Scientist?question toggle

    As a Principal Scientist, there are potential career advancement opportunities into roles such as Chief Scientist, Research & Development Director and even leadership positions.