Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Systems Engineer, Manager - Operations
$121K - $164K *
Champion a team of analysts to enhance enterprise infrastructure services, ensuring reliable support and operational excellence. Collaborate with cross-functional teams to align priorities and drive c...
6 days ago
Document Control Specialist - Remote, US
$88K - $154K *
Transform document management processes by overseeing workflows, tracking, and compliance for critical projects. Leverage your expertise to enhance efficiency and ensure accurate record retention whil...
2 weeks ago
Director of Business Development
$135K - $150K *
Champion growth by leading strategic business development initiatives, forging partnerships, and driving revenue expansion. Collaborate with executives to align goals and enhance market presence while...
2 days ago
Senior Manager, Project Controls, Project & Development Services
$148K - $175K *
Elevate your career by providing strategic oversight of project controls, balancing technical leadership with client advisory support. Mentor teams and influence delivery models while contributing to...
2 weeks ago
Senior Principal Consultant, Medicaid Programs
$158K - $185K *
Unlock your potential by leading the design and delivery of a transformative Medicaid data platform. Collaborate with stakeholders and guide teams to modernize healthcare systems through innovative cl...
1 week ago
Account Development Representative
$85K - $130K *
Transform client engagement by driving strategic sales initiatives within Fortune 500 accounts. Collaborate with cross-functional teams to generate qualified leads and enhance customer experiences, ul...
3 weeks ago
Senior Manager, Global Scientific Communications & Engagement Strategy- Content Lead
$141K - $191K *
Champion high-impact scientific communication strategies, collaborating across Medical Affairs and Commercial. Lead content development, enhance engagement, and drive operational excellence for effect...
1 month ago
Regulatory Policy and Intelligence Associate Director
$155K - $210K *
Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...
Today
Associate Director, Converged TV
$129K - $147K *
Champion innovative digital video strategies, focusing on CTV, while leading cross-functional teams to optimize campaign performance and drive growth in a dynamic advertising environment...
6 days ago
$105K - $120K *
Help us drive sales growth and enhance community partnerships by leading a dynamic sales team focused on expanding market share and improving patient registrations in the healthcare sector...
Today
Senior Account Manager, Promotional Medical Education
$85K - $95K *
Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...
1 week ago
$110K - $130K *
Champion growth in the retail sector by driving account development and sales. Leverage strong customer relationships to enhance satisfaction and profitability while effectively managing your sales pi...
Reposted 2 weeks ago
Manager - Federal Financial Reporting
$120K - $160K *
Lead the charge in federal financial reporting, ensuring compliance and audit readiness while managing contract performance and serving as a liaison between stakeholders and auditors. Drive high-quali...
Today
Operations Support & Strategy Manager
$109K - $144K *
Join a dynamic team to drive operational excellence and process improvements in healthcare. Lead complex initiatives, influence strategy, and enhance care delivery while collaborating across multiple...
3 days ago
Healthcare Tech Manager - Epic Patient Access
$130K - $150K *
Drive impactful solutions as a Healthcare Technology Manager, optimizing Epic Patient Access systems. Collaborate with clients and teams to enhance workflows and deliver sustainable results in a suppo...
1 week ago
Sr Business Analyst Manhattan Scale
$87K - $115K *
Optimize warehouse operations by implementing WMS solutions. Collaborate with teams to enhance workflows, lead testing, and ensure successful deployments, driving efficiency and scalability in logisti...
2 weeks ago
Vice President Procurement and Contracting
$150K - $180K *
Transform procurement and contracting strategies to enhance efficiency, compliance, and cost savings. Lead cross-functional teams, drive digital transformation, and ensure supplier performance while s...
Reposted today
$115K - $145K *
Engage in the development and delivery of innovative training programs that enhance the skills and performance of sales teams in the pharma/biotech sector, ensuring alignment with strategic goals and...
3 weeks ago
Senior Corporate Development and Planning Analyst
$95K - $115K *
Take ownership of financial and operational analysis for strategic initiatives, delivering critical insights and reporting to support executive decision-making while driving accuracy and efficiency in...
Reposted 1 week ago
Senior Strategic Implementation Consultant
$109K - $165K *
Build strong relationships at a leading IoT company, guiding enterprise customers through deployment and adoption of innovative solutions. Collaborate cross-functionally while driving customer success...
Reposted 4 weeks ago
SC ABP Sales Executive, Senior
$138K - $161K *
Elevate your career by driving transformative supply chain solutions. Lead strategic account relationships, develop executive strategies, and create new business opportunities within a dynamic environ...
1 week ago
Lead Solutions Architect - DERMS
$103K - $154K *
Unlock your potential as a vital member of a client-focused team, leveraging your expertise to drive successful pre-sales engagements, solutions delivery, and client management in the dynamic utility...
Reposted 6 days ago
Lead Solutions Architect - DERMS
$103K - $154K *
Innovate and lead technical solutions for utility challenges, driving strategic growth through effective pre-sales engagement and deep collaboration with clients and internal teams to deliver tailored...
Reposted 2 weeks ago
Head of Product - Business Banking
$289K - $362K *
Deliver outstanding business banking solutions by leading product strategy, optimizing user experiences, and driving growth through innovative AI-powered products. Build a high-performing team and ens...
Reposted 4 weeks ago
Sr. Manager, AI Performance & Operations
$110K - $173K *
Join a team that's redefining AI-driven quality and performance operations. You'll build systems that enhance frontline team effectiveness and AI agent performance, ensuring impactful coaching and fee...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.