Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Revenue Cycle Jobs in South Dakota

Sort By: Relevance

$121K - $164K *

Champion a team of analysts to enhance enterprise infrastructure services, ensuring reliable support and operational excellence. Collaborate with cross-functional teams to align priorities and drive c...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $154K *

Transform document management processes by overseeing workflows, tracking, and compliance for critical projects. Leverage your expertise to enhance efficiency and ensure accurate record retention whil...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$135K - $150K *

Champion growth by leading strategic business development initiatives, forging partnerships, and driving revenue expansion. Collaborate with executives to align goals and enhance market presence while...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$148K - $175K *

Elevate your career by providing strategic oversight of project controls, balancing technical leadership with client advisory support. Mentor teams and influence delivery models while contributing to...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$158K - $185K *

Unlock your potential by leading the design and delivery of a transformative Medicaid data platform. Collaborate with stakeholders and guide teams to modernize healthcare systems through innovative cl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $130K *

Transform client engagement by driving strategic sales initiatives within Fortune 500 accounts. Collaborate with cross-functional teams to generate qualified leads and enhance customer experiences, ul...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$141K - $191K *

Champion high-impact scientific communication strategies, collaborating across Medical Affairs and Commercial. Lead content development, enhance engagement, and drive operational excellence for effect...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $210K *

Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$129K - $147K *

Champion innovative digital video strategies, focusing on CTV, while leading cross-functional teams to optimize campaign performance and drive growth in a dynamic advertising environment...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$105K - $120K *

Help us drive sales growth and enhance community partnerships by leading a dynamic sales team focused on expanding market share and improving patient registrations in the healthcare sector...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$85K - $95K *

Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion growth in the retail sector by driving account development and sales. Leverage strong customer relationships to enhance satisfaction and profitability while effectively managing your sales pi...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $160K *

Lead the charge in federal financial reporting, ensuring compliance and audit readiness while managing contract performance and serving as a liaison between stakeholders and auditors. Drive high-quali...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$109K - $144K *

Join a dynamic team to drive operational excellence and process improvements in healthcare. Lead complex initiatives, influence strategy, and enhance care delivery while collaborating across multiple...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $150K *

Drive impactful solutions as a Healthcare Technology Manager, optimizing Epic Patient Access systems. Collaborate with clients and teams to enhance workflows and deliver sustainable results in a suppo...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$87K - $115K *

Optimize warehouse operations by implementing WMS solutions. Collaborate with teams to enhance workflows, lead testing, and ensure successful deployments, driving efficiency and scalability in logisti...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$150K - $180K *

Transform procurement and contracting strategies to enhance efficiency, compliance, and cost savings. Lead cross-functional teams, drive digital transformation, and ensure supplier performance while s...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$115K - $145K *

Engage in the development and delivery of innovative training programs that enhance the skills and performance of sales teams in the pharma/biotech sector, ensuring alignment with strategic goals and...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Take ownership of financial and operational analysis for strategic initiatives, delivering critical insights and reporting to support executive decision-making while driving accuracy and efficiency in...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$109K - $165K *

Build strong relationships at a leading IoT company, guiding enterprise customers through deployment and adoption of innovative solutions. Collaborate cross-functionally while driving customer success...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$138K - $161K *

Elevate your career by driving transformative supply chain solutions. Lead strategic account relationships, develop executive strategies, and create new business opportunities within a dynamic environ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$103K - $154K *

Unlock your potential as a vital member of a client-focused team, leveraging your expertise to drive successful pre-sales engagements, solutions delivery, and client management in the dynamic utility...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Business Services

$103K - $154K *

Innovate and lead technical solutions for utility challenges, driving strategic growth through effective pre-sales engagement and deep collaboration with clients and internal teams to deliver tailored...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$289K - $362K *

Deliver outstanding business banking solutions by leading product strategy, optimizing user experiences, and driving growth through innovative AI-powered products. Build a high-performing team and ens...

RemoteRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $173K *

Join a team that's redefining AI-driven quality and performance operations. You'll build systems that enhance frontline team effectiveness and AI agent performance, ensuring impactful coaching and fee...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.