Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$80K - $95K *
Lead the design and delivery of impactful training programs, creating engaging learning materials and facilitating sessions to enhance employee skills and knowledge across various business units. Driv...
Today
Director, Consulting & Advisory Alliances, North America
$150K - $170K *
Join a team that's expanding strategic partnerships with consulting firms to enhance supply chain solutions. Drive growth through collaboration, relationship management, and innovative go-to-market st...
Yesterday
$95K - $115K *
Unlock the potential of implementation science as a Senior Program Analyst, driving quality improvement and program evaluation initiatives. Manage processes, databases, and reporting to enhance projec...
1 week ago
Director/Sr. Director Clinical Pharmacology
$262K - $284K *
Optimize pediatric drug development strategies as a clinical pharmacology leader, overseeing pharmacometric analyses and regulatory submissions, while translating complex data into actionable decision...
Reposted 4 weeks ago
RVP, Enterprise Sales - Southeast
$231K - $363K *
Lead the charge in driving enterprise partnerships across the Southeast, focusing on selling an AI-powered care platform to enhance employer healthcare strategies and reduce costs while ensuring high...
3 weeks ago
$80K - $90K *
Lead the charge in managing comprehensive accounting functions for self-insurance groups, ensuring accurate financial reporting, compliance with regulations, and effective budget management while coll...
1 week ago
$104K - $130K *
Empower growth by transforming complex data into actionable insights. Collaborate with senior leaders to build analytical tools and models that drive strategic decisions, while enhancing operational e...
2 days ago
Manager, Client Strategy & Operations
$100K - $120K *
Join a team that's focused on enhancing client delivery and relationship growth. Drive data-driven strategies and cross-functional collaboration to optimize post-sale operations, ensuring exceptional...
Reposted 2 weeks ago
$100K - $125K *
Join our dynamic finance team as you drive margin and profitability through detailed analysis and strategic insights. Collaborate with senior leadership to transform data into actionable initiatives t...
1 week ago
Senior Quality Operations Specialist, Audit
$74K - $98K *
Champion regulatory audit excellence by leading PACE audits, ensuring compliance, and driving cross-functional collaboration to enhance operational readiness and continuous improvement across the orga...
3 weeks ago
$175K - $400K *
Elevate your career by managing the lifecycle of vendor agreements and contracts. Collaborate across departments to ensure compliance and streamline workflows, safeguarding business interests while mi...
3 weeks ago
Senior Manager, US Indirect Tax Controversy
$155K - $228K *
Drive the execution of US indirect tax audits, managing processes and cross-functional collaboration to ensure accurate outcomes. Leverage analytics and mentor team members while navigating complex ta...
3 weeks ago
$130K - $155K *
Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...
Yesterday
$145K - $156K *
Optimize resource allocation in a dynamic creative studio, ensuring efficient talent management and fostering strong relationships with artists and project leads. Drive proactive planning and problem...
2 weeks ago
$96K - $144K *
Take ownership of contract management by drafting, negotiating, and administering agreements with key customers. Collaborate with cross-functional teams to ensure compliance and operational efficiency...
Yesterday
Vice President, Engineering, EPM
$212K - $265K *
Drive transformative software engineering across EPM products, lead modernization, build innovative SaaS capabilities, and enhance operational excellence in a high-impact role overseeing global teams...
1 month ago
Sr. CTM/Associate Director, QED Alliance support
$145K - $177K *
Join a team that's dedicated to advancing clinical trials for rare diseases. As a Senior Clinical Trial Manager, you'll lead operational execution, ensuring compliance and quality while fostering stro...
3 weeks ago
Lead, Operations Strategy - Specialty Services Implementation
$90K - $100K *
Join a dynamic team to drive the implementation of innovative service lines, enhancing clinician and patient experiences. Collaborate cross-functionally to optimize operations and lead initiatives tha...
2 weeks ago
Regional Vice President - Enterprise Sales
$100K - $185K *
Transform enterprise banking by driving sales of innovative SaaS solutions. Leverage your expertise to identify key clients, build relationships, and close complex deals, all while collaborating with...
3 weeks ago
$165K - $210K *
Drive innovation as you lead a data science team focused on generative AI and machine learning. Shape scalable solutions that address business challenges, leveraging advanced analytics to deliver meas...
2 weeks ago
Director, National Accounts (non-TI)
$150K - $180K *
Champion the growth of strategic travel partnerships by leading enterprise sales efforts, securing high-value accounts, and leveraging modern sales frameworks to drive commercial success in a fast-pac...
2 days ago
$160K - $200K *
Join a team that's redefining IT leadership, ensuring robust security and operational excellence across global platforms while driving innovation and growth at scale through strategic technology solut...
Reposted 3 weeks ago
$80K - $95K *
The Data Integration Specialist at Timely will ensure seamless integration of data between school district systems and Timely's scheduling technology. This role involves collaborating with various sta...
Reposted 4 weeks ago
Forward Deployed Process Consultant- R37
$113K - $226K *
Lead the charge in optimizing healthcare processes by bridging strategy and execution. Collaborate with teams to enhance coding workflows, drive change management, and ensure alignment with strategic...
2 weeks ago
Regional Director, Clinical Sales - Central
$150K - $180K *
Transform the clinical sales landscape by leading a regional team to drive utilization growth, enhance patient treatment metrics, and foster cross-functional collaboration for commercial success in in...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.