Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Innovation Portfolio Strategy Principal
$138K - $191K *
Join a team that's redefining healthcare innovation by translating ideas into impactful solutions. Collaborate with senior executives to drive strategic initiatives and enhance population health throu...
2 days ago
Director, Software Engineering - Platform Development
$150K - $180K *
Join a dynamic team to lead the development of innovative Microsoft-based platforms, driving modernization and AI integration while ensuring robust, scalable, and secure solutions in a highly regulate...
1 week ago
$80K - $95K *
Transform your career by enhancing data security and integrity. Collaborate with cross-functional teams to implement robust security measures, conduct audits, and mitigate risks while staying ahead of...
2 weeks ago
$110K - $130K *
Elevate strategic insights and performance reporting for pharmaceutical media. Collaborate across teams, leveraging data analytics and AI solutions to enhance growth and client outcomes in a fast-pace...
Reposted 4 weeks ago
Senior Director, Oncology Pharmacology
$232K - $348K *
Lead the charge in oncology pharmacology, managing scientific teams to drive drug discovery from early stages through regulatory approval while ensuring alignment across cross-functional teams...
Reposted 1 week ago
Director, Identity & Access Management (IAM)
$180K - $200K *
Manage and execute a comprehensive IAM strategy, ensuring robust identity security across corporate and cloud environments. Lead a team to implement Zero Trust principles and enhance identity governan...
2 weeks ago
$64K - $134K *
Drive success by managing key accounts, ensuring revenue growth through strategic upselling and relationship building. Collaborate with clients and internal teams to deliver exceptional service and ac...
1 week ago
$262K - $412K *
Engage with us to redefine market strategies and elevate Thrive's positioning. Lead product marketing, competitive intelligence, and commercial enablement to ensure our innovative solutions resonate w...
3 weeks ago
Associate Director, Global Commercial Trade Compliance
$138K - $188K *
Lead global trade compliance initiatives, ensuring adherence to regulations across multiple jurisdictions. Drive strategic programs for import/export operations, risk management, and partner governanc...
Yesterday
$125K - $220K *
Drive security excellence by leading a dynamic team to enhance our cloud platform's security posture. Collaborate across departments to ensure compliance, resilience, and customer trust while fosterin...
3 weeks ago
Senior Sales Executive, Supply Chain Finance
$125K - $150K *
Take ownership of driving new-logo growth for our Supply Chain Finance solution. Engage with senior executives, manage the full sales cycle, and develop strategies to acquire high-value customers in f...
3 weeks ago
Senior Director, Real Estate & Workplace Strategy
$190K - $210K *
Advance our real estate strategy by leading portfolio planning, workplace design, and data analysis. Collaborate with internal teams and external partners to optimize office spaces, enhance employee e...
6 days ago
Product Manager - Service of Process
$110K - $120K *
Accelerate product development by leading end-to-end processes, integrating advanced technologies, and driving outcomes across a suite of digital solutions for legal service operations, while ensuring...
Reposted 2 weeks ago
Account Executive (San Antonio, TX)
$85K - $100K *
Join a team that's dedicated to building strong client relationships through face-to-face sales. Leverage your expertise in outside sales to drive growth and maximize your earning potential in a dynam...
1 week ago
District Business Manager - Syracuse, NY
$122K - $204K *
Accelerate progress at driving market expansion by leading a high-performing district team, fostering collaboration, and executing strategic business plans to enhance customer engagement and revenue g...
Reposted 4 days ago
Lead Project Manager, Delivery
$115K - $158K *
Join a team that's driving innovation in project management for enterprise decisioning. Collaborate across business and technology teams to ensure successful delivery of complex initiatives while main...
2 days ago
Project Manager - Medical Communications
$80K - $95K *
Advance your career by managing diverse medical communications projects, ensuring timely delivery and client satisfaction while leading multidisciplinary teams and maintaining strong relationships wit...
3 weeks ago
Sr. CRA, FSP - Surgical / Medical Device - Central region
$130K - $133K *
Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...
1 week ago
VP, Global Sales, Inventory & Operations Planning
$175K - $210K *
Lead the global SIOP process, ensuring synchronization across Sales, Marketing, and Supply Chain functions to optimize inventory and enhance operational efficiency for $1.2B in annual sales. Drive str...
Reposted 3 days ago
$112K - $140K *
Elevate your career by managing complex property claims, advising brokers, and resolving coverage issues. Collaborate with teams to ensure positive outcomes and develop strategic solutions in a dynami...
3 weeks ago
$100K - $120K *
Join a team that's redefining employee payment solutions. As an Implementation Manager, oversee the deployment of our SaaS product for diverse clients, ensuring successful integrations and fostering s...
Reposted 2 weeks ago
Vice President, Medicaid Partnerships
$150K *
Elevate Medicaid partnerships by driving strategic sales initiatives, securing contracts, and fostering client relationships. Lead a team to achieve growth targets while navigating market dynamics and...
3 weeks ago
$153K - $210K *
Transform your career by partnering with teams to drive strategic growth through legal expertise in healthcare contracts, negotiations, and compliance. Collaborate with leadership to optimize performa...
3 weeks ago
Energy Cash Management Director
$130K - $235K *
Innovate cash management strategies in a high-volume invoicing environment. Lead a dynamic team to enhance billing accuracy and efficiency, leveraging AI and automation to optimize processes and drive...
2 weeks ago
Internal Communications Manager
$88K - $147K *
Inspire and elevate employee engagement through strategic internal communications. Collaborate with leaders to craft and deliver impactful messaging that drives understanding of company goals and fost...
Reposted 3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.