Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$90K - $110K *
Join a team that's redefining change management in healthcare. Support the adoption of innovative informatics solutions, ensuring seamless transitions and user readiness across the Veterans Health Adm...
4 weeks ago
Associate Director, US Patient Advocacy
$164K - $225K *
Develop and execute patient advocacy strategies, engaging with PAOs and cross-functional teams to elevate the patient voice and ensure successful partnerships for rare disease therapeutic areas...
Reposted 6 days ago
SVP -Business Development Officer -SBA & CRE
$150K - $180K *
Transform your career by driving growth in commercial real estate financing. This role focuses on originating and structuring loans while building strong relationships with clients and industry profes...
Reposted 2 days ago
Director, Business Development
$150K - $180K *
Unlock new opportunities as you drive business growth in the life sciences sector. Focus on building relationships and matching client needs with innovative solutions in commercial consulting, brand c...
Reposted 4 weeks ago
Client Engagement Manager - Post-Pay, Specialist
$125K - $187K *
Elevate client engagement by leading post-payment integrity implementations, ensuring seamless communication and alignment across teams. Drive successful outcomes through expert knowledge and strategi...
Yesterday
VP OmniAnalyst Product Manager
$150K - $180K *
Transform enterprise data into valuable insights while leading AI-powered product strategies. Drive cross-functional collaboration to deliver secure, innovative, and measurable data capabilities that...
Reposted 4 weeks ago
Senior Director, Investor Relations
$192K - $256K *
Deliver impactful investor relations strategies that enhance company visibility, build investor confidence, and drive long-term shareholder value. Collaborate with senior leadership to translate compl...
Reposted yesterday
Tribal Services Accounting Manager
$66K - $182K *
Unlock potential by joining a collaborative team dedicated to delivering exceptional accounting and consulting services to Tribal governments, enhancing client relationships and driving impactful solu...
2 weeks ago
Senior Claims Specialist/Claims Technical Director - Great American Risk Solutions
$90K - $125K *
Transform complex commercial casualty claims management by leveraging your expertise in construction-related exposures and litigation. Collaborate with a dedicated team to deliver exceptional outcomes...
6 days ago
Director of Facilities & Procurement
$110K - $130K *
Drive the safety and efficiency of 100+ schools by managing facilities and procurement. Lead a team, oversee capital planning, negotiate contracts, and ensure operational excellence to create a secure...
Yesterday
Treasury Manager, Capital Markets
$110K - $130K *
Manage key capital markets activities, overseeing debt operations, cash flow forecasting, and financial risk management. Collaborate with stakeholders to prepare executive materials and support pensio...
Yesterday
$100K - $140K *
Transform your career by leveraging your RCM expertise to drive sales success. Collaborate with cross-functional teams to enhance customer experiences and optimize billing solutions for small to mediu...
3 weeks ago
Innovation Portfolio Strategy Principal
$138K - $191K *
Join a team that's redefining healthcare innovation by translating ideas into impactful solutions. Collaborate with senior executives to drive strategic initiatives and enhance population health throu...
2 days ago
Director, Software Engineering - Platform Development
$150K - $180K *
Join a dynamic team to lead the development of innovative Microsoft-based platforms, driving modernization and AI integration while ensuring robust, scalable, and secure solutions in a highly regulate...
1 week ago
$80K - $95K *
Transform your career by enhancing data security and integrity. Collaborate with cross-functional teams to implement robust security measures, conduct audits, and mitigate risks while staying ahead of...
2 weeks ago
$110K - $130K *
Elevate strategic insights and performance reporting for pharmaceutical media. Collaborate across teams, leveraging data analytics and AI solutions to enhance growth and client outcomes in a fast-pace...
Reposted 4 weeks ago
Senior Director, Oncology Pharmacology
$232K - $348K *
Lead the charge in oncology pharmacology, managing scientific teams to drive drug discovery from early stages through regulatory approval while ensuring alignment across cross-functional teams...
Reposted 1 week ago
Director, Identity & Access Management (IAM)
$180K - $200K *
Manage and execute a comprehensive IAM strategy, ensuring robust identity security across corporate and cloud environments. Lead a team to implement Zero Trust principles and enhance identity governan...
2 weeks ago
$64K - $134K *
Drive success by managing key accounts, ensuring revenue growth through strategic upselling and relationship building. Collaborate with clients and internal teams to deliver exceptional service and ac...
1 week ago
$262K - $412K *
Engage with us to redefine market strategies and elevate Thrive's positioning. Lead product marketing, competitive intelligence, and commercial enablement to ensure our innovative solutions resonate w...
3 weeks ago
Associate Director, Global Commercial Trade Compliance
$138K - $188K *
Lead global trade compliance initiatives, ensuring adherence to regulations across multiple jurisdictions. Drive strategic programs for import/export operations, risk management, and partner governanc...
Yesterday
$125K - $220K *
Drive security excellence by leading a dynamic team to enhance our cloud platform's security posture. Collaborate across departments to ensure compliance, resilience, and customer trust while fosterin...
3 weeks ago
Senior Sales Executive, Supply Chain Finance
$125K - $150K *
Take ownership of driving new-logo growth for our Supply Chain Finance solution. Engage with senior executives, manage the full sales cycle, and develop strategies to acquire high-value customers in f...
3 weeks ago
Senior Director, Real Estate & Workplace Strategy
$190K - $210K *
Advance our real estate strategy by leading portfolio planning, workplace design, and data analysis. Collaborate with internal teams and external partners to optimize office spaces, enhance employee e...
6 days ago
Product Manager - Service of Process
$110K - $120K *
Accelerate product development by leading end-to-end processes, integrating advanced technologies, and driving outcomes across a suite of digital solutions for legal service operations, while ensuring...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.