Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Field Reimbursement Manager - Central
$110K - $130K *
Drive patient access to Provenge by removing reimbursement barriers and collaborating with healthcare stakeholders. Develop strategies to enhance business growth while navigating complex payer policie...
6 days ago
Director, Nursing Inpatient Trauma
$100K - $120K *
Unlock potential by providing clinical and administrative leadership to enhance patient care standards. Collaborate with medical staff and departments to ensure compliance and drive strategic initiati...
2 weeks ago
$100K - $120K *
Explore opportunities to partner with engineers and stakeholders, translating technical discussions into actionable deliverables while supporting CI/CD initiatives and repository governance with a foc...
3 weeks ago
Senior Enterprise Account Executive, Western US
$145K - $165K *
Champion revenue growth by building partnerships with city officials and transport operators. Navigate complex sales cycles, execute market plans, and provide strategic insights for sustainable public...
Reposted 2 weeks ago
$135K - $155K *
Drive impactful data solutions by bridging business needs with engineering teams. Own project intake, prioritize requests, and ensure clear communication across departments to enhance efficiency and d...
1 week ago
Director, Industry Practice Lead - Corporate Enterprise
$160K - $200K *
Elevate your career by joining a dynamic team focused on transforming corporate learning. As a senior leader, you'll drive strategic initiatives, engage with top executives, and shape the future of wo...
1 week ago
Senior Manager, REMS Operations
$141K - $212K *
Deliver strategic oversight and operational management for FDA-mandated REMS programs, ensuring compliance, governance, and collaboration across teams and vendors to enhance program effectiveness and...
3 weeks ago
$125K - $150K *
Transform your career by leading GTM enablement initiatives that equip sales and marketing teams with essential training, certifications, and resources to drive success in a rapidly scaling organizati...
3 weeks ago
Sr. Practice Manager -- Data Platforms
$150K - $190K *
Lead the charge in shaping data platform strategies and governance, driving innovative solutions and team development. Collaborate with partners to enhance AI readiness and ensure successful technical...
2 weeks ago
Manager, Strategic Finance (GTM & Revenue)
$120K - $145K *
Take ownership of financial planning and analysis efforts, driving insights and process improvements to enhance business performance as we support a rapidly growing, innovative dental technology compa...
Reposted 1 week ago
$100K - $120K *
Drive your career with a team leading customer renewals. Manage a skilled group focused on achieving retention targets, effective negotiations, and proactive customer engagement, all while collaborati...
4 weeks ago
Associate Vice President, Clinical Services - Market Access Marketing
$180K - $220K *
Champion clinical services initiatives, driving strategic content development and mentoring teams to enhance market access and client success. Lead projects, ensure compliance with standards, and reso...
Reposted 3 weeks ago
$140K - $176K *
Lead the charge in managing a high-performing PMO team, driving project success through strategic financial oversight, talent development, and cross-functional collaboration to enhance operational eff...
3 weeks ago
Director of Sales - Healthcare and Life Sciences
$100K - $140K *
Accelerate your career by driving new business growth and managing enterprise client relationships. Leverage your expertise in managed sales solutions to exceed targets and optimize sales processes in...
1 week ago
Head of National Strategic Accounts
$250K - $300K *
Champion strategic growth by leading the charge to secure complex health system accounts. Drive transformative deals with hands-on coaching, leveraging deep relationships and expertise to elevate team...
Reposted 2 weeks ago
$176K - $293K *
Develop and implement strategic account plans to drive sales growth and build relationships with key decision-makers in healthcare. Collaborate with cross-functional teams to achieve business goals an...
3 weeks ago
$102K - $120K *
Join a team that's transforming healthcare analytics by bridging complex data with strategic insights. Leverage your SQL expertise and analytics engineering skills to empower stakeholders and drive va...
3 weeks ago
Value & Access Insights Sr. Manager, Medical Benefit Products
$163K - $220K *
Shape the future of healthcare by leading analytics for managed care, driving payer strategies, and delivering insights to enhance access to medical benefit products. Collaborate with cross-functional...
3 weeks ago
$83K - $155K *
Contribute to the success of hygienic sensors by owning product strategy, collaborating with engineering, and driving market insights into actionable requirements. Lead product launches and manage lif...
1 week ago
Claims Configuration Senior Manager
$110K - $150K *
Unlock potential by leading claims adjudication logic to enhance accuracy and efficiency. Drive strategic improvements, collaborate across teams, and ensure compliance while optimizing operations in a...
4 days ago
Supply Chain Contracting Manager- GPO
$96K - $118K *
Join a dynamic team to develop and manage supply chain contracting strategies that optimize costs and enhance value for member pharmacies. This role involves supplier negotiations, category performanc...
2 weeks ago
$95K - $149K *
Lead the charge in delivering complex product development projects by managing cross-functional teams, ensuring customer satisfaction, and driving operational excellence from initiation to delivery in...
3 weeks ago
Manager, Global Central Operations - Remote
$100K - $120K *
Drive operational excellence by leading global partnerships and enhancing efficiency. Collaborate with teams to achieve strategic goals, support change management, and ensure accountability in meeting...
3 weeks ago
Director, Strategic Advisory Services - Theranostics, Radiopharmaceuticals, and Oncology
$156K - $235K *
Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...
6 days ago
Director, Sales & Operation Planning
$130K - $160K *
Transform the planning landscape by leading integrated sales and operations processes. Drive cross-functional collaboration, develop robust planning models, and ensure alignment on business objectives...
Reposted yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.