Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Strategic Account Manager - Southeast
$125K - $150K *
Drive strategic growth as you build relationships with C-level executives, lead complex sales cycles, and exceed quotas in selling enterprise-level SaaS solutions to $20bn+ clients while managing a de...
Reposted 4 weeks ago
$120K - $145K *
Shape the future of cyber claims management by leading a dynamic team, driving strategic initiatives, and ensuring exceptional service delivery while adhering to industry standards and regulatory requ...
1 week ago
Regional Director of Clinical Operations
$100K - $120K *
Shape the future of healthcare by leading clinical operations across 3-5 skilled nursing facilities in eastern South Dakota, ensuring regulatory compliance and quality care while managing multiple tea...
Reposted 1 week ago
$110K - $130K *
Empower your career by joining a dynamic Deal Desk team to support global sales. Drive deal execution and manage the end-to-end deal lifecycle, enhancing operational efficiency and collaborating acros...
Reposted 1 week ago
Medical Review Nurse - Commercial DME Auditor
$80K - $95K *
Transform healthcare auditing by conducting thorough medical claims reviews. Collaborate with a dynamic team to ensure compliance and improve processes while working remotely in a fast-paced environme...
1 week ago
$115K - $145K *
Transform product strategy into actionable backlogs, guiding delivery through agile practices. Collaborate with cross-functional teams to prioritize features, manage defects, and ensure alignment with...
1 week ago
$90K - $110K *
Lead the charge in optimizing business processes and technology solutions, serving as the primary liaison between stakeholders and technical teams to enhance operational efficiency and customer experi...
2 weeks ago
Director, Utility Field Services
$215K - $235K *
Transform operations at multiple locations by leading field services, ensuring safety, quality, and profitability while driving growth in relay protection and controls. Collaborate with teams to execu...
1 week ago
Director, Translational Pharmacokinetics - DMPK
$177K - $283K *
Unlock potential by leading pharmacokinetic modeling for early-stage drug development. Collaborate with cross-functional teams to enhance drug absorption, distribution, metabolism, and excretion (ADME...
1 week ago
$120K - $145K *
Drive impactful program management by leading cross-functional initiatives, ensuring alignment with strategic goals, and delivering measurable results in a dynamic environment. Collaborate effectively...
1 week ago
Director of Enterprise Reporting and Special Projects
$125K - $150K *
Champion the enhancement of financial reporting processes and efficiencies, ensuring accurate visibility into organizational performance. Collaborate with leadership on strategic projects to drive ope...
1 week ago
Payer Engagement Lead - Regional Accounts
$214K - $234K *
Champion strategic payer engagement across regional markets, building relationships that enhance patient access to therapies. Connect national strategies with local execution for optimal outcomes in c...
Reposted 3 weeks ago
$150K - $180K *
Shape the future of security by leading our first dedicated security function. You'll build and execute a comprehensive security program, ensuring safe AI adoption while protecting sensitive health da...
1 week ago
Senior Operational Strategy Director
$203K - $304K *
Champion innovative operational strategies in clinical research, driving excellence in bid defense meetings and proposal development. Collaborate with cross-functional teams to enhance study execution...
2 weeks ago
Associate Director, Clinical Data Integration & AI Programming
$158K - $197K *
Unlock potential by leading the automation of clinical data integration and dashboard development. Collaborate across teams to enhance data usability and implement AI solutions, ensuring compliance an...
4 weeks ago
Sr. Practice Manager -- AI Agentic Ops
$150K - $190K *
Help us shape the future of AI operations by leading a dynamic team focused on innovative solutions, strategic partnerships, and technical excellence in agentic environments. Drive growth and operatio...
1 week ago
$110K - $130K *
Lead the optimization of cross-pillar workflows, ensuring technical soundness and operational effectiveness. Collaborate with engineering and product teams to enhance product adoption and drive measur...
2 weeks ago
Cross-Centers Service Delivery Operations Lead
$120K - $145K *
Transform enterprise service delivery by leading cross-center operations, enhancing efficiency, and ensuring high-quality IT services across multiple locations. Drive initiatives that improve performa...
3 weeks ago
$100K - $125K *
Shape the future of organizational change by developing strategies, managing transitions, and driving transformation initiatives. Collaborate with teams to enhance productivity and ensure successful i...
1 week ago
$95K - $112K *
Transform legal operations by streamlining processes, enhancing data management, and implementing innovative technology solutions. Collaborate cross-functionally to optimize workflows and support a sc...
6 days ago
Manager, Business Development, National Center for Clinical Trials (NCCT)
$114K - $171K *
Join a team that's driving growth in clinical trials by identifying and securing partnerships. Collaborate with cross-functional leaders to enhance visibility and expand opportunities, ensuring seamle...
3 weeks ago
$100K - $130K *
Transform healthcare by leading a dynamic PMO, ensuring program transparency and compliance across multiple customer accounts while fostering collaboration and continuous improvement...
Yesterday
Customer Journey Operations Manager
$120K - $150K *
Accelerate customer journey operations by driving scalable processes and systems. Collaborate cross-functionally to enhance customer success, technical support, and partner engagement, ensuring effici...
1 week ago
$75K - $90K *
Unlock potential by leading accounting services for diverse clients, managing month-end closings, and mentoring junior staff. Utilize your expertise to build client relationships and drive operational...
Today
Director, Product Management (Remote)
$150K - $180K *
Unlock potential by leading the product strategy for B2B email and identity data solutions. Collaborate with cross-functional teams to drive product launches, enhance capabilities, and engage with cli...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.