Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Product Manager, Provider Experience
$170K - $220K *
Drive product strategy and development to enhance clinician experience, optimizing patient care through innovative solutions and stakeholder collaboration across a nationwide healthcare network...
2 weeks ago
Director of Product , Data Flywheel
$200K - $245K *
Pioneer data-driven engineering for our Autonomy Data Flywheel initiative, overseeing the entire lifecycle to enhance AI-driven operations. Collaborate with cross-functional teams to achieve quality a...
Reposted 4 weeks ago
Manager, CMC Quality, Pulmovant
$110K - $130K *
Lead quality oversight for drug manufacturing, ensuring compliance with cGMPs. Collaborate with vendors on batch record review and product disposition for global clinical programs, thriving in a dynam...
1 week ago
$140K - $170K *
Champion the go-to-market strategy for streaming advertising, leading a product marketing team to craft compelling messaging and drive revenue growth. Collaborate across departments to ensure alignmen...
1 week ago
$100K - $120K *
Unlock potential by leading the General Accounting function, ensuring accurate financial reporting and robust internal controls while driving continuous improvement and team development in a dynamic e...
6 days ago
$150K - $180K *
Unlock potential by leading a dynamic team in Workforce Management and Quality Assurance. Drive operational excellence, vendor partnerships, and innovative strategies to enhance service delivery and p...
1 week ago
Director, Sales Strategy & Operations - Groups
$170K - $230K *
Elevate the sales strategy and operations by partnering with leadership to enhance productivity, implement AI solutions, and drive data-driven decision-making. Lead a team to optimize processes and en...
1 week ago
$110K - $125K *
Drive the Reuse function within the Product Lifecycle team, ensuring efficient operations, stakeholder communication, and process consistency to support the mission of serving Veterans. Lead a team fo...
2 weeks ago
Director of Strategic Partnerships
$100K - $150K *
Transform the future of business development by building strategic partnerships across key professional services. Drive growth through relationship-building and co-closing deals, while shaping a natio...
3 weeks ago
Sr. Director, Cybersecurity Advisory Services
$160K - $200K *
Drive growth in a leading Cyber Consulting Services organization by enhancing operational performance, managing diverse teams, and delivering high-quality cybersecurity solutions while ensuring client...
3 weeks ago
Senior Director / Director , Breast Oncology Lifecycle Management
$186K - $233K *
Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...
3 weeks ago
Medical Affairs and Evidence Generation Asset Lead – Executive Director
$325K - $447K *
Elevate medical affairs by providing strategic insights for clinical asset development and commercialization. Lead cross-functional teams, execute evidence generation plans, and foster collaboration t...
Reposted 1 week ago
Project Director-Hydro Projects
$132K - $220K *
Lead the charge in managing Renewable Energy Hydro Projects, driving execution strategies to maximize performance, ensuring timely delivery, and fostering strong customer relationships while overseein...
3 weeks ago
Unified Communications Analyst
$80K - $95K *
Champion seamless communication by managing VoIP and telephony systems, ensuring optimal performance and user satisfaction. Collaborate across departments to analyze data, enhance workflows, and uphol...
2 weeks ago
$175K - $210K *
Elevate your career by owning the sales cycle for major employers, building strategic partnerships, and driving innovative health programs that shape enterprise success and market presence...
1 month ago
Senior Business Systems Architect
$167K - $183K *
Lead the charge in optimizing G&A technology solutions, enhancing business processes through AI and automation. Collaborate with stakeholders to drive efficiency and compliance, ensuring scalable grow...
3 weeks ago
$95K - $115K *
Partner with us to drive sales operations excellence, ensuring effective workflows, data integrity, and actionable insights in a dynamic environment while supporting strategic initiatives and enhancin...
Reposted 1 week ago
Sr Program Manager, Client Delivery
$155K - $180K *
Drive successful delivery of complex, multi-year programs in a dynamic environment. Collaborate with cross-functional teams to manage scope, budget, and timelines while ensuring client satisfaction an...
3 weeks ago
Product Owner - Professional Coding
$110K - $130K *
Transform product vision into reality by leading the Encoder solution, managing backlogs, and collaborating with stakeholders to maximize value and user satisfaction. Drive strategic decisions and ens...
3 weeks ago
$120K - $160K *
Manage labor and employment legal matters, ensuring compliance and providing strategic counsel. Collaborate with HR and stakeholders to develop solutions, supervise outside counsel, and educate on pol...
Yesterday
$90K - $100K *
Join a team that's dedicated to ensuring sales compensation accuracy and integrity. You'll support deal desk operations and provide analytical insights, making a significant impact on revenue processe...
1 week ago
Senior Director, Service Manager
$163K - $261K *
Shape the future of electrification services by leading operations across the West U.S. region, driving performance excellence, and managing nationwide digital automation initiatives while advancing r...
Reposted 2 weeks ago
Sr. Account Manager - Health Plans
$180K - $205K *
Champion client success by managing strategic accounts, driving growth, and enhancing relationships with health plans. Collaborate cross-functionally to deliver tailored solutions and ensure seamless...
1 week ago
Business Information Security Officer
$125K - $225K *
Champion cybersecurity initiatives by aligning strategies with business goals, managing risks, and fostering a security-conscious culture. Collaborate with stakeholders to enhance security posture and...
Today
$133K - $210K *
Lead the charge in shaping security operations by architecting SIEM, driving automation, and mentoring a dedicated team. Your expertise will enhance threat detection and incident response, ensuring ro...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.