Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Executive Director, Sales - West
$295K - $325K *
Drive strategic sales leadership across the Western US, translating brand vision into effective field execution. Build and sustain a high-performing team while collaborating cross-functionally to achi...
Yesterday
Channel Development Manager - Ohio Valley
$110K - $130K *
Empower channel growth by managing key partnerships, driving sales acceleration, and collaborating with cross-functional teams to exceed performance goals in the Ohio Valley Region...
1 week ago
$195K - $230K *
Drive growth by leading go-to-market strategies for TMC partnerships, building and executing plans from the ground up. Collaborate cross-functionally to influence product development and represent the...
1 week ago
Vice President, Media Products| US: Remote
$268K - $282K *
Shape the future of media products by driving strategy and innovation. Collaborate with cross-functional teams to enhance measurement and optimization capabilities, ensuring impactful solutions for cl...
Yesterday
Manager, Corporate Development
$115K - $150K *
Champion strategic growth by leading M&A initiatives, conducting financial analysis, and collaborating with cross-functional teams to drive successful transactions and enhance corporate capabilities...
1 week ago
$125K - $150K *
Drive integrated, compliant media strategies for pharmaceutical brands, leading channel planning, investment decisions, and client engagement to achieve impactful business outcomes throughout launch a...
Reposted 4 weeks ago
Sr Director/Director, Neurology Patient Marketing
$251K - $307K *
Champion innovative patient marketing strategies that drive engagement and awareness for a first-in-class therapy in Becker muscular dystrophy, collaborating across teams to enhance patient experience...
Reposted 2 days ago
Associate Director, Product (Data)
$165K - $175K *
Empower progress at the forefront of data product management, leading the development of innovative solutions. Drive product success through strategic oversight, client engagement, and cross-functiona...
3 weeks ago
Lead Product Manager, Channels
$126K - $173K *
Shape the future of enterprise decisioning by leading cross-functional product initiatives that enhance customer experiences and drive operational readiness across multiple business channels...
2 days ago
Senior Manager, Finance Transformation
$170K - $200K *
Shape the future of finance transformation by prioritizing systems requests and process improvements. Collaborate across teams to enhance operations and drive impactful change in a fast-paced, dynamic...
2 days ago
Senior Technical Program Manager
$115K - $172K *
Shape the future of healthcare by leading complex data ingestion initiatives. Collaborate with cross-functional teams to drive program delivery, manage risks, and ensure operational excellence while t...
Today
$85K - $95K *
Transform client relationships by delivering exceptional service and support, ensuring seamless communication and issue resolution while collaborating with internal teams to enhance client satisfactio...
2 weeks ago
Account Executive, Mid Market (TOLA)
$152K - $190K *
Reimagine how mid-sized organizations leverage IoT data to drive efficiency and safety. As an integral sales force, you will engage with key decision-makers to build relationships, manage projects, an...
Reposted yesterday
Director, Global Total Rewards
$180K - $210K *
Drive the evolution of Total Rewards by integrating compensation, benefits, and technology to enhance employee experience and support organizational growth through strategic leadership and operational...
4 weeks ago
Director, Customer Solutions – Navy
$190K - $200K *
Manage strategic customer engagement and growth within Navy and DoD sectors. Leverage existing networks and industry insights to identify business opportunities that align with Millennium’s objectives...
Reposted today
Vice President & General Manager, Connected Solutions - South Florida
$160K - $200K *
Optimize operational excellence and client service as a senior leader overseeing a complex Connected Solutions hub, ensuring high standards in production, technical operations, and team performance fo...
6 days ago
Senior Executive Director Finance
$121K - $145K *
Strategize financial operations and enhance reporting accuracy while leading the finance team. Collaborate with senior leadership to drive financial sustainability and operational efficiency across bu...
6 days ago
Sr. Manager of Medicare Compliance
$110K - $130K *
Champion compliance excellence by leading innovative technology integration and regulatory strategies across Medicare Advantage and Part D channels, ensuring seamless operations and enhanced agent eff...
2 weeks ago
Associate Director - Finance and Accounting
$125K - $150K *
Join a team that's dedicated to enhancing client engagement through innovative solutions in Finance and Accounting. Collaborate across diverse departments to expand market share and cultivate lasting...
Reposted 3 weeks ago
Sr. Advisory Consultant, Data Governance
$110K - $130K *
Take ownership of data governance by facilitating alignment among stakeholders, executing metadata management, and coaching teams on sustainable stewardship practices. Drive data quality and complianc...
Reposted 3 weeks ago
$130K - $216K *
Lead complex healthcare data initiatives by managing teams, translating business needs into technical solutions, and ensuring data quality and integration. Collaborate with stakeholders to drive analy...
Yesterday
$183K - $220K *
Lead strategic initiatives for Integrated Delivery Networks and health systems, optimizing patient access and formulary adoption. Build executive relationships and drive clinical integration to enhanc...
6 days ago
Director, Upscale Revenue Management
$163K - $192K *
Unlock potential by leading a dynamic team to optimize revenue strategies across Upscale Brands. Drive performance, enhance service delivery, and ensure franchisee success through effective change man...
3 weeks ago
Director of Finance, Care in Action
$110K - $120K *
Partner with us to lead financial management for Care in Action, overseeing budgeting, reporting, and compliance across multiple entities. Drive strategic financial stewardship while ensuring organiza...
1 week ago
$100K - $120K *
Manage diverse tax projects, fostering client relationships and mentoring staff. Oversee tax return reviews and compliance, while identifying growth opportunities in a dynamic environment. Collaborate...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.