Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Revenue Cycle Jobs in South Dakota

Sort By: Relevance

$225K - $281K *

Join a team that's pushing the boundaries of oncology research! This key role involves designing and leading clinical trials, ensuring data integrity, and collaborating with global experts to advance...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$225K - $281K *

Explore your career in clinical development as you design and lead innovative oncology studies, ensuring data integrity and compliance while collaborating with cross-functional teams and cultivating r...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$170K - $185K *

Champion technical sales execution across diverse domains, driving alignment with growth priorities. Lead a high-performing team, enhance customer outcomes, and provide strategic insights to elevate s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $170K *

Pioneer innovative solutions in P&C insurance by owning the product roadmap for policy administration and commercial underwriting, integrating AI capabilities to enhance decision-making and streamline...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$174K - $203K *

Empower clinical innovations by leading statistical strategies in oncology trials. Collaborate with cross-functional teams to design studies, analyze data, and support regulatory submissions, ensuring...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$274K - $371K *

Elevate patient care through innovative clinical strategies in obesity and cardiometabolic development. Collaborate across teams to design and implement late-phase studies, ensuring alignment with glo...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Drive the marketing strategy and execution from the ground up. Collaborate with cross-functional teams to build scalable demand-generation programs to boost qualified pipeline and revenue for innovati...

United StatesRemote

Reposted 1 month ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join us to lead strategy and implementation for long-term services and supports, ensuring compliance and enhancing participant experience in a dynamic healthcare environment. Drive impactful partnersh...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$121K - $176K *

Transform operational excellence by leading a team to implement Lean strategies, drive continuous improvement initiatives, and enhance safety, quality, and cost performance across multiple sites while...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$138K - $150K *

Analyze and manage corporate portfolio growth through strategic projects and business development. Collaborate with cross-functional teams to drive M&A initiatives and evaluate market opportunities, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $150K *

Accelerate progress at a leading firm by managing corporate portfolio growth through strategic projects and business development in digital health and emerging technologies. Collaborate with managemen...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $147K *

Lead a dynamic team in enhancing member-centered care through effective utilization management. Drive quality improvement, ensure compliance, and foster strategic partnerships to optimize healthcare d...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$134K - $185K *

Drive financial systems integration and automation projects, collaborating with global teams to support month-end tasks and enhance SAP Finance operations. Ensure seamless financial close and effectiv...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$144K - $160K *

Champion operational excellence by leading teams to enhance efficiency and care delivery. Drive AI integration, manage P&L, and collaborate cross-functionally to support growth and sustainability in h...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$247K - $309K *

Unlock potential by leading medical strategy for hematologic malignancies. Collaborate cross-functionally to drive evidence generation, stakeholder engagement, and launch readiness, ensuring impactful...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the charge in overseeing a dynamic transaction management team, driving commercial real estate activities, and ensuring alignment with client goals while fostering staff development and operation...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$120K - $150K *

Lead enterprise account renewals, driving retention and growth through strategic relationships with executives. Manage a significant book of business, ensuring customer satisfaction and navigating com...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $135K *

Join a team that's transforming Medicaid agencies through expert OCM strategies. Leverage your project management and change management skills to enhance health outcomes and build stronger communities...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$170K - $205K *

Drive the integration and growth of a newly acquired business, overseeing P&L, client relationships, and operations. Collaborate with teams to ensure seamless transition and performance against revenu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$192K - $288K *

Join a team that's driving strategic initiatives in Neuroscience and Oncology. In this pivotal role, you'll partner with leadership to enhance operations, manage budgets, and streamline workforce plan...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$128K - $178K *

Lead the evolution of our CMS and AI web strategy, driving product vision and execution for public sector clients. Collaborate with cross-functional teams to deliver innovative, customer-focused solut...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $152K *

Elevate the synergy between Sales strategy and technology delivery, translating business needs into actionable engineering specifications. Drive system enhancements and ensure seamless collaboration a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Join a team that's driving growth in the biopharmaceutical sector by developing strategic business relationships, prospecting new clients, and leading sales initiatives to achieve organizational objec...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $202K *

Drive product operations excellence by leading cross-functional teams, enhancing AI integration, and optimizing UX design to ensure a seamless product development lifecycle that empowers rapid, high-q...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$78K - $83K *

Shape the future of audit excellence by developing innovative concepts, mentoring teams, and ensuring quality control. Drive client satisfaction and enhance audit productivity through strategic oversi...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.