Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Revenue Cycle Jobs in South Dakota

Sort By: Relevance

$110K - $130K *

Champion the end-to-end management of complex healthcare programs, ensuring operational readiness and compliance. Collaborate with teams and clients to drive successful implementations while maintaini...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead complex healthcare project initiatives, ensuring successful implementation and operational readiness while maintaining high standards of governance. Foster strong partnerships with clients, manag...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$133K - $171K *

Shape the future of digital video strategy by leading CTV initiatives, optimizing performance, and fostering innovation. Collaborate with teams to connect audience insights with client goals, ensuring...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$217K - $298K *

Lead the charge in shaping Root's platform and AI engineering strategy, overseeing critical infrastructure and driving operational excellence across teams to deliver intelligent products at scale...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$86K - $138K *

Champion financial analysis and reporting by conducting in-depth research, preparing forecasts, and collaborating across departments to enhance decision-making and drive business success...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $138K *

Lead the strategy and execution of enterprise data exchange products, ensuring secure and standardized data sharing. Collaborate with stakeholders to drive interoperability and maximize business value...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Drive portfolio value creation through strategy execution, leveraging your extensive experience in revenue growth and go-to-market capabilities to lead engagements and mentor GTM teams across technolo...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$200K - $230K *

Lead customer success initiatives by managing federal program delivery, ensuring seamless deployment, support, and renewal processes. Drive team performance and build strategic partnerships to enhance...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$120K - $150K *

Lead the technical authority for anaerobic wastewater treatment, driving innovation and optimization across a growing portfolio. Collaborate with cross-functional teams to enhance biogas production an...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$92K - $115K *

Unlock potential by leading requirements documentation for software projects. Collaborate with stakeholders and technical teams to ensure successful delivery throughout the project lifecycle, while su...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$102K - $154K *

Shape customer success by managing complex escalations, driving improvements, and coordinating cross-functional teams. Your leadership will enhance workflows and ensure high-quality resolutions, makin...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $111K *

Elevate your career by implementing lease accounting solutions, optimizing client software use, and collaborating with teams to enhance product functionality and documentation. Drive success in enterp...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$174K - $234K *

Champion the development and governance of global transfer pricing strategies, ensuring alignment with business operations and compliance across jurisdictions while leading cross-functional collaborat...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Help us drive change management initiatives in life sciences R&D, enhancing efficiency and effectiveness across research, clinical, and regulatory operations while leading stakeholder engagement and a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $140K *

Join a dynamic team as you take ownership of the accounting function, managing spend, payables, and reconciliations. Drive process improvements and leverage AI to enhance workflows, ensuring accuracy...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$175K - $210K *

Join a team that's transforming financial oversight globally, ensuring compliance and efficiency. Lead accounting processes, enhance internal controls, and drive automation while mentoring a high-perf...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$151K - $207K *

Unlock potential by driving strategic growth in healthcare sales, fostering executive relationships, and leading cross-functional teams to achieve commercial targets across Siemens Healthineers' Imagi...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by driving growth through strategic partnerships in the TSD ecosystem. This role focuses on recruiting and managing Trusted Advisors, generating opportunities, and collaborating wi...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$265K - $300K *

Shape the future of neurodegenerative disease diagnostics by leading scientific strategy, driving research programs, and building expert networks to establish industry leadership in innovative solutio...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Business Services

$149K - $248K *

Champion client engagement and operational excellence by managing consulting teams, driving quality standards, and fostering relationships within Military Health Systems. Lead new business development...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$134K - $219K *

Lead clinical laboratory operations for precision medicine projects, ensuring timely deliverables and risk management across therapeutic areas. Collaborate with cross-functional teams to support clini...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$164K - $305K *

Join a team that's redefining account management by driving growth and retention for complex health systems. Build strategic relationships with C-suite executives and lead cross-functional teams to de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$170K - $200K *

Unlock potential by providing strategic legal counsel on clinical and commercial operations, focusing on regulatory compliance, privacy, and data protection in a dynamic biopharmaceutical environment...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Healthcare

$184K - $254K *

Shape the future of corporate strategy by leading cross-functional teams to develop enterprise-wide strategic plans, drive growth initiatives, and influence senior leadership decisions through data-dr...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$275K - $340K *

Drive growth by leading sales and customer success teams, refining strategies, and optimizing processes. Shape the commercial landscape while mentoring talent and ensuring high-value customer relation...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.