Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$125K - $170K *
Lead the charge in managing complex contracts for a major program, ensuring compliance and strategic alignment. Collaborate with teams to develop proposals, negotiate terms, and maintain strong relati...
1 week ago
$160K - $200K *
Lead the charge in strategic pre-award contracting, driving compliance and operational excellence. Oversee a high-performing team while collaborating across functions to enhance efficiency and support...
4 weeks ago
Director of Data Governance (Remote Work Option)
$165K - $175K *
Drive the strategic execution of an enterprise data governance program, shaping policies and fostering collaboration among stakeholders to enhance data quality and compliance across the organization...
2 weeks ago
Associate Medical Director- Rare Neuro
$175K - $200K *
Drive strategic medical initiatives in Rare Neurology, collaborating with cross-functional teams to enhance patient outcomes. Leverage your expertise to shape launch strategies and foster relationship...
Reposted 2 days ago
$225K - $295K *
Accelerate progress at the forefront of contract lifecycle management by driving innovation and strategic solutions. Collaborate with sales teams to enhance customer satisfaction and market leadership...
3 weeks ago
Regional Sales Director (Chicago)
$112K - $143K *
Unlock new business growth by managing relationships and executing sales strategies across a designated territory. Drive market share expansion and achieve revenue targets through strategic networking...
2 weeks ago
Resource Management & Digitization Leader
$91K - $152K *
Lead workforce planning, optimize resources, and drive digital transformation initiatives while enhancing operational visibility and efficiency across global service operations in a remote capacity...
Reposted 6 days ago
Sr Financial Accounting Specialist
$76K - $142K *
Lead advanced accounting functions, ensuring compliance with GAAP and SAP. Prepare complex financial reports and analyses while collaborating with auditors. Drive financial accuracy and support manage...
2 weeks ago
Senior Financial Analyst - Strategic Finance
$109K - $173K *
Elevate your career by partnering with us to enhance financial forecasting and reporting processes. Leverage your analytical skills to improve business intelligence systems and drive key performance i...
Reposted 4 days ago
$150K - $175K *
Accelerate growth through strategic demand generation and integrated marketing campaigns. Collaborate with Sales and Product teams to optimize the pipeline, drive revenue, and enhance customer engagem...
3 weeks ago
System Director Digital Technology - Information Systems Administration - FT - Day
$145K - $175K *
Transform healthcare technology by leading digital innovation, data management, and AI initiatives. Collaborate across teams to enhance patient experience and operational performance while driving the...
Yesterday
$180K - $220K *
Unlock your potential by driving enterprise growth in healthcare. Join a dynamic team focused on building relationships with health systems and provider organizations, leveraging a robust support engi...
1 week ago
Associate Director, Product Quality
$117K - $189K *
Join a team that's shaping the future of pharmaceutical quality by leading compliance initiatives and building a robust Quality Management System to support innovative therapies in a dynamic, collabor...
2 weeks ago
Operations Lead, Strategic Growth Initiatives
$160K - $180K *
Join us as a strategic operator to drive high-priority growth initiatives, aligning cross-functional teams and transforming ideas into actionable plans while leveraging AI tools for enhanced efficienc...
2 days ago
Manager, Credentialing & Medical Staff Services
$110K - $125K *
Elevate healthcare operations by leading credentialing and medical staff services across multiple states. Drive compliance, streamline onboarding, and enhance workflows to support over 200 professiona...
2 weeks ago
Regional Chief Technology Officer, NAMER West
$170K - $240K *
Unlock potential by serving as a key technical advisor, engaging with C-level executives to drive business growth through strategic enterprise architecture guidance, public speaking, and thought leade...
3 weeks ago
Senior Revenue Operations Leader
$175K - $190K *
Transform revenue operations by leading AI-driven initiatives, optimizing tech stacks, and enhancing cross-functional collaboration. Drive measurable outcomes while building a high-performing team tha...
4 weeks ago
$155K - $185K *
Partner with us to lead high-impact projects in healthcare marketing, managing budgets and teams while ensuring creative excellence and strategic alignment. Drive client success through collaboration...
Today
Director, Market Access - Commercial Coverage & Reimbursement
$187K - $281K *
Redefine market access strategies by leading payer engagement to enhance patient access to genomic testing. Collaborate cross-functionally to drive favorable coverage and reimbursement policies, ensur...
Today
Senior Director, Corporate Counsel
$175K - $210K *
Lead corporate legal strategy and M&A transactions, guiding complex deals and governance. Manage a growing legal team, develop processes, and partner with senior leadership to drive business initiativ...
1 week ago
Associate Director, CMC Regulatory
$177K - $221K *
Lead the development and execution of global CMC regulatory strategies to support clinical trials and market applications, ensuring compliance with regulatory requirements throughout the product lifec...
1 week ago
$135K - $160K *
Optimize our finance function by leading planning and forecasting efforts, transitioning to automated systems, and driving data analysis that informs strategic decisions. This role offers full ownersh...
1 week ago
Associate Director, Omnichannel Marketing - Prostate Cancer
$170K - $213K *
Transform customer engagement by leading omnichannel marketing strategies, collaborating with cross-functional teams, and leveraging data insights to enhance HCP and patient experiences in the pharmac...
2 days ago
$110K - $130K *
Innovate revenue operations by owning the order-to-cash process, enhancing billing systems, and implementing automation. Collaborate with cross-functional teams to streamline revenue recognition and e...
2 weeks ago
Senior Business Analyst (MMIS Finance)
$85K - $111K *
Unlock your potential by leading business and functional requirements for Medicaid financial management. Collaborate with diverse teams to enhance payment operations and ensure compliance while drivin...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.