Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Sys SVP Financial Planning and Analysis
$210K - $250K *
Drive strategic financial planning and analysis to optimize resource allocation, support executive decision-making, and enhance operational performance across the organization, ensuring alignment with...
2 weeks ago
Director, Data & Distribution Partnerships
$190K - $275K *
Advance the Data & Distribution Partnerships function by innovating and scaling data reseller and distribution models, building commercial arrangements, and leading a team to create revenue-generating...
Reposted 2 weeks ago
$104K - $130K *
Join a team that's driving project success in mission-critical environments. As a Project Manager, you'll oversee design and construction phases, manage stakeholder relations, and ensure project profi...
4 weeks ago
Senior Manager, Finance Operations
$110K - $130K *
Manage and oversee finance operations, leading accounts payable and billing functions across multiple regions. Ensure accuracy and compliance in procure-to-pay and order-to-cash processes while buildi...
1 week ago
$120K *
Empower change by leading legislative engagement strategies in Texas, driving clean energy initiatives, and building impactful relationships with policymakers and coalitions to advance the advanced en...
Reposted 3 weeks ago
Client Success Manager, Payer Retrieval
$108K - $130K *
Unlock your potential by leading customer projects, ensuring seamless communication, and driving success in healthcare solutions. Collaborate with diverse teams to enhance client satisfaction and oper...
1 week ago
Vice President- Advanced Technical Services
$250K - $500K *
Transform delivery services by owning P&L and driving strategy across complex networks and AI solutions. Lead a large-scale team, ensuring quality and efficiency while enhancing customer satisfaction...
Reposted 3 weeks ago
Account Executive, Midwest ECM
$80K - $95K *
Unlock potential by driving growth in our Enterprise Content Management business. Engage with diverse stakeholders, navigate complex sales cycles, and expand client relationships across the Midwest wh...
Yesterday
Director of Business Operations
$125K - $150K *
Transform business operations by leading systems and technology initiatives that enhance efficiency, drive AI enablement, and streamline processes across the organization, ensuring a robust foundation...
2 weeks ago
$160K - $175K *
Empower client success by leading account health, driving growth, and managing budgets. Collaborate with cross-functional teams to deliver integrated campaigns while mentoring your account team and en...
Reposted 5 days ago
$120K - $145K *
Lead the charge in defining and executing a comprehensive value stream vision, driving cross-industry adoption through innovative workflows and AI-enabled experiences, while collaborating with industr...
6 days ago
Director, PDM Planning & Operations
$125K - $150K *
Deliver strategic leadership for a centralized partner data management system, ensuring alignment with business priorities and enhancing user experience. Collaborate with cross-functional teams to dri...
2 weeks ago
$135K - $170K *
Optimize your sales career by managing the full sales cycle for a leading engineering software. Leverage your technical expertise to drive revenue growth and deliver impactful solutions to industrial...
2 weeks ago
Director, Client Strategy and Growth
$185K - $210K *
Engage with clients to drive retention and growth strategies, fostering deep relationships and collaboration across teams. Leverage market insights to enhance product offerings and ensure client succe...
3 weeks ago
Senior Manager, Finance & Strategy - Go-To-Market
$183K - $228K *
Drive strategic financial insights as a key partner to the go-to-market teams, owning revenue forecasts and investment economics. Collaborate with leadership to shape long-term growth strategies and e...
Reposted 2 weeks ago
Senior Director, Business System Strategy & Transformation
$180K - $215K *
Lead the charge in transforming supply chain technology strategies, driving innovation and operational excellence across S2P and O2C value streams. Collaborate with cross-functional teams to enhance d...
Reposted 3 weeks ago
Associate Director, Regional Marketing (Midwest Region)
$120K - $145K *
Join a team that's driving regional marketing initiatives in hematology and oncology. Engage with key thought leaders, execute strategic plans, and leverage local opportunities to enhance brand presen...
3 weeks ago
Associate Director, Real-World Analytics Programming
$186K - $233K *
Empower the future of real-world analytics by leading programming activities for observational studies, ensuring high-quality deliverables through collaboration with cross-functional teams and innovat...
3 weeks ago
Program Manager - United Concordia Dental
$94K - $151K *
Shape the future of enterprise strategy by leading a diverse portfolio of programs and initiatives. Collaborate with cross-functional teams to drive measurable business value and ensure alignment with...
2 weeks ago
Director, Mainframe Systems Programming
$135K - $205K *
Lead the charge in delivering client-focused mainframe solutions. Oversee diverse projects, manage teams, and leverage strategic insights to enhance hardware and software lifecycle management while fo...
3 weeks ago
Director, Strategy and Special Projects
$141K - $204K *
Drive strategic growth for DSD by leveraging data, analytics, and tools to enhance operational performance and achieve expansion goals. Collaborate with leadership to support initiatives that elevate...
1 week ago
$144K - $173K *
Shape the future of pharmaceutical media by leading client strategy and integrated media delivery. Drive audience engagement, manage high-impact relationships, and leverage data insights to achieve me...
2 weeks ago
Senior Revenue Operations Analyst
$80K - $100K *
Optimize revenue growth by driving GTM excellence and data-driven insights. Collaborate across Sales, Customer Success, and Finance to establish streamlined operations and enhance performance reportin...
Reposted 2 weeks ago
Director, Merchant Experience - Strategy & Operations
$197K - $290K *
Transform the merchant support experience by leading strategy and execution to enhance satisfaction and retention. Collaborate cross-functionally to implement data-driven initiatives that drive seamle...
1 week ago
Program Manager, Implementation (Launch)
$100K - $120K *
Transform healthcare delivery by leading program initiatives that drive partner success in value-based care. Utilize data-driven strategies to manage launch processes, ensuring alignment across teams...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.