Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Lead Product Manager, Value realization
$126K - $173K *
Drive impactful measurement strategies by leading cross-functional teams to define and deliver comprehensive reporting solutions that enhance decision-making and optimize business outcomes across the...
3 days ago
Director, Enterprise Enablement
$150K - $180K *
Drive transformative AI initiatives across departments by leading a strategic team in designing scalable, agentic workflows that enhance decision-making and efficiency, ensuring measurable business ou...
Reposted 3 days ago
Director, Project Management & Resource Operations
$150K - $172K *
Drive strategic leadership for project and resource management, ensuring timely delivery and optimal resource utilization. Collaborate with cross-functional teams to enhance customer experience and fi...
3 weeks ago
Associate Director Commercial Strategy and Planning
$146K - $178K *
Shape the future of biopharma by leading commercial strategy engagements, guiding clients through critical launch decisions, and delivering evidence-based recommendations to drive success in a dynamic...
1 week ago
$72K - $107K *
Join a team that's dedicated to enhancing resident development through effective program management, collaboration with clinical leaders, and innovative professional development sessions to ensure a s...
Today
Director, Procurement & Vendor Management
$150K - $186K *
Transform procurement strategies by leading vendor management and building strategic partnerships. Drive operational efficiency while optimizing spend and enhancing supplier performance to support lon...
3 weeks ago
$80K - $95K *
Join us to lead a dynamic team in optimizing revenue cycle operations for multiple clients. Drive continuous improvement and ensure client satisfaction while managing performance metrics and fostering...
2 days ago
Manager, Regulatory Affairs (Clinical Labeling)
$110K - $130K *
Take ownership of IMP labeling processes, ensuring compliance with global regulations and quality standards while collaborating cross-functionally to support clinical trial timelines and enhance label...
4 weeks ago
Regional Manager, Channel Central
$150K - $180K *
Transform the Central Region's channel strategy by leading a high-performing team, driving revenue growth, and fostering strategic partnerships. Collaborate with executives to align goals and maximize...
2 weeks ago
Senior Director, Investor Relations & Strategic Finance
$217K - $310K *
Elevate your career by leading investor relations and strategic finance initiatives. Collaborate with executives to craft compelling narratives, build investor relationships, and drive impactful finan...
1 week ago
Director, Marketing Operations
$150K - $180K *
Lead the charge in optimizing marketing operations to drive developer adoption, pipeline growth, and revenue. Oversee systems, processes, and insights while collaborating with cross-functional teams t...
2 weeks ago
$132K - $153K *
Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...
6 days ago
Director of Accounting Operations
$115K - $135K *
Shape the future of our Accounting Operations by leading a dynamic team, ensuring accuracy and efficiency in financial processes, and driving improvements through automation and AI integration...
1 week ago
Vice President, CMC Regulatory Affairs
$272K - $340K *
Elevate your career by leading CMC Regulatory strategy and execution. Drive submissions, build a high-performing team, and engage with global health authorities to ensure compliance and success in dru...
1 week ago
$115K - $135K *
Shape the future of clinical trials by leading site monitoring efforts, ensuring compliance, and fostering collaboration across teams. Drive quality and efficiency in trial execution while mentoring j...
3 weeks ago
$164K - $305K *
Lead the charge in developing strategic relationships with C-suite executives to drive growth, retention, and value realization across complex health systems, ensuring integrated solutions and measura...
1 week ago
Executive Director, Key Accounts Lead
$228K - $285K *
Shape the future of market access by leading strategic account initiatives, fostering key relationships, and driving collaboration across teams to enhance product access and reimbursement in the oncol...
1 week ago
$120K - $250K *
Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...
2 weeks ago
Senior Vice President, Growth & Commercialization
$210K - $250K *
Lead a dynamic team to drive growth and commercialization strategies, enhancing market presence and client acquisition. Collaborate cross-functionally to transform insights into actionable plans, ensu...
Today
$80K - $95K *
Empower our rehabilitation team by leading operations, ensuring compliance, and enhancing patient care. Drive financial success and foster strong relationships with staff and clients while maintaining...
2 weeks ago
Manager, Commercial Accounting
$134K - $145K *
Optimize commercial accounting processes by managing revenue, inventory, and accounts receivable. Collaborate with cross-functional teams to ensure accurate financial reporting and drive process impro...
4 weeks ago
Regional Business Manager - Midwest Region
$110K - $130K *
Transform sales performance by leading and coaching a high-performing team, optimizing strategies, and driving innovative customer engagement in a dynamic biopharmaceutical environment...
3 weeks ago
$75K - $105K *
Tackle comprehensive project management for onboarding HME providers, driving digital transformation across healthcare. Collaborate strategically, enhance platform adoption, and leverage data insights...
4 weeks ago
12 - Director, Business Development 1
$140K - $195K *
Engage in strategic business development, overseeing global projects and teams. Drive long-term planning, policy formation, and customer negotiations while fostering collaboration with senior manageme...
Reposted 3 days ago
Senior Director, Clinical Quality Assurance (CQA)
$245K - $286K *
Elevate clinical quality assurance through strategic leadership and oversight of global trials, ensuring compliance with GCP regulations. Drive quality culture and inspection readiness while mentoring...
Reposted 3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.