Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director - Professional Coding (Remote)
$190K - $252K *
Join a team that's redefining professional coding leadership, overseeing coding operations, quality audits, and education initiatives. Drive strategic objectives that enhance patient care and revenue...
Today
IT Service Delivery Program Manager, Healthcare
$110K - $130K *
Empower healthcare IT delivery by managing a dynamic team, ensuring operational excellence, and driving EMR performance. Collaborate with clinical stakeholders to enhance patient care through effectiv...
1 week ago
$150K - $180K *
Lead a high-performing sales team to drive new logo acquisition and revenue growth in enterprise software. Develop strategies, foster collaboration, and engage executive customers to expand market sha...
3 days ago
$110K - $130K *
Empower client relationships by managing outsourcing engagements, optimizing processes, and leading a team. Drive operational excellence and identify new opportunities for service expansion while ensu...
1 week ago
$120K - $150K *
Empower a healthcare association by leading strategic initiatives, fostering partnerships, and driving revenue growth. Collaborate with stakeholders to enhance program excellence and ensure effective...
3 weeks ago
Account Executive - Integrator Sales
$95K *
Join a team that's driving growth by managing key Integrator accounts, developing sales strategies, and fostering relationships to exceed corporate goals in the material handling industry...
2 weeks ago
Manager, Clinical Stewardship Operations (RN)
$150K - $165K *
Build and manage clinical stewardship operations, driving client success through effective program implementation and cross-functional collaboration. Leverage clinical expertise to enhance client rela...
2 days ago
Product Manager - Data Migration
$113K - $197K *
Unlock the potential of product strategy and execution by leading cross-functional teams to deliver innovative solutions. Drive enterprise transformations and ensure alignment with business objectives...
1 week ago
Project Manager, Delivery Lead
$95K - $115K *
Elevate project delivery by leading cross-functional teams in Interactive Response Technology, ensuring client satisfaction and timely execution while managing risks and fostering continuous improveme...
3 weeks ago
Clinical Operations Manager-F- budgets and contracts - FSP
$110K - $130K *
Drive clinical operations excellence by managing protocol compliance, delivering budget oversight, and ensuring successful study start-up in alignment with regulatory standards and internal policies w...
Reposted yesterday
People Ops Process Transformation Lead
$101K - $204K *
Unlock potential by leading the redesign of People Operations processes. Drive operational excellence through strategic assessments, workflow mapping, and implementation of innovative solutions that e...
2 weeks ago
Director, Real World Data Strategy
$197K - $239K *
Join us to lead AI-driven innovation in real-world data strategy, translating business priorities into actionable insights. Drive data intelligence and collaboration across teams to enhance evidence g...
Reposted 1 week ago
$175K - $200K *
Transform compliance within a dynamic enterprise by designing and overseeing an effective Ethics and Compliance Program that aligns with regulations and promotes enterprise growth. Drive culture and a...
Reposted yesterday
$140K - $170K *
Join a dynamic team to optimize operational systems, drive growth, and enhance performance across departments. Collaborate with leadership to ensure strategic goals translate into measurable results a...
6 days ago
$98K - $130K *
Drive financial excellence by leading cost accounting operations, ensuring accurate reporting and analysis. Collaborate across departments to support strategic business decisions and contribute to tim...
Today
Lead Director - Digital Engineering
$144K - $288K *
Lead the charge in transforming customer identity platforms, driving modernization and operational excellence while overseeing a multi-team engineering organization to enhance security and customer en...
1 week ago
Director, Field Effectiveness, Rare Disease and Oncology
$193K - $262K *
Champion the sales force's success by leading a dynamic team focused on optimizing field effectiveness and operational efficiency, driving excellence in performance and insights...
1 month ago
Sr. Manager, Revenue Accounting
$120K - $145K *
Drive the end-to-end revenue lifecycle and lead a high-performing team in optimizing order-to-cash operations. Collaborate cross-functionally to ensure compliance with ASC 606 while enhancing automati...
1 week ago
$110K - $145K *
Shape the future of energy efficiency by leading complex client programs and strategic initiatives. Drive portfolio success through operational excellence, financial performance, and strong client rel...
Today
Senior Coding Compliance Auditor - Outpatient
$76K - $131K *
Join a team that's redefining healthcare compliance by leading detailed coding audits, mentoring auditors, and driving innovative solutions to enhance compliance and operational excellence in a dynami...
3 weeks ago
$194K - $285K *
Innovate in the credit space by leading a dynamic underwriting team. Drive strategy, mentor talent, and establish best-in-class credit programs while collaborating with internal and external partners...
1 week ago
$160K - $190K *
Transform ambiguity into action by driving strategic initiatives across functions. Collaborate with executives to architect programs that enhance operational efficiency and deliver measurable business...
3 weeks ago
Client Success Executive - Prescription Benefits
$80K - $95K *
Drive client success by leading strategic account teams, ensuring satisfaction, and fostering strong relationships. Leverage expertise to enhance service delivery and support client retention through...
Reposted yesterday
Manager, Client Delivery Experience (Output Solutions and Commercialization) - Remote
$105K - $163K *
Lead and manage client-facing teams to deliver high-quality card processing projects, ensuring successful implementations and client satisfaction through effective project management and strategic ove...
6 days ago
$150K - $180K *
Accelerate channel growth by leading a high-performing team of Channel Managers, establishing strategic partnerships, and driving execution across the ecosystem to enhance overall performance and deve...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.