Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Assistant Director, Global Service Delivery
$100K - $120K *
Advance global service delivery by managing offshore partnerships, ensuring performance excellence, and driving operational improvements across teams to enhance productivity and quality outcomes...
6 days ago
Assistant General Counsel - Managed Services Organization
$150K - $235K *
Elevate your legal career by delivering strategic counsel and effective services to Managed Services Organizations and physician practices, while managing complex legal projects and mentoring a team i...
2 weeks ago
$120K - $145K *
Accelerate progress at the forefront of pricing strategy and operations. Lead cross-functional teams to innovate pricing models, enhance profitability, and drive market competitiveness while managing...
3 days ago
Director, Business Development
$110K - $130K *
Drive growth by shaping strategic partnerships and optimizing processes in a dynamic business development role. Collaborate with teams to enhance e-commerce performance, create lead generation strateg...
Reposted 4 weeks ago
Director, Project Controls, Project & Development Services (Data Centers)
$161K - $190K *
Drive strategic planning and scheduling for large-scale capital programs, focusing on data center delivery. Lead teams, establish best practices, and influence stakeholders to ensure successful projec...
1 week ago
Account Executive (CPQ Solutions)
$135K - $200K *
Unlock potential by driving customer growth and engagement through consultative selling, leveraging AI insights to enhance account strategies and foster strong relationships with existing clients and...
3 weeks ago
Group Director, Client Media Solutions
$175K - $200K *
Lead the charge in developing integrated media strategies and client partnerships across pharmaceutical and life sciences accounts, driving business growth and ensuring exceptional delivery and client...
1 week ago
$211K - $272K *
Transform your career by leading enterprise applications strategy and delivery. Collaborate with cross-functional teams to enhance processes, drive AI adoption, and ensure robust application architect...
Today
VP Finance & Global Controller
$175K - $210K *
Elevate your career by leading global financial operations, ensuring accurate reporting and compliance across multiple entities. Drive innovation in financial systems and processes while mentoring a h...
2 weeks ago
Sr. Manager, Strategic Growth & Proposal Perf
$116K - $145K *
Optimize proposal performance and strategic growth initiatives, leading a collaborative team to enhance RFP responses, competitive positioning, and resource allocation for maximum impact and success a...
Reposted 2 weeks ago
Senior Director, Facilities, Real Estate & Security Operations
$159K - $215K *
Join a team that's driving operational excellence across 25+ sites, overseeing facilities, real estate, and security operations to ensure safe, efficient environments that support high-quality care de...
Today
Director of Procurement (Remote)
$110K - $130K *
Shape the future of procurement by leading strategic sourcing initiatives, enhancing vendor relationships, and driving financial transparency. Collaborate across teams to streamline processes and leve...
3 weeks ago
Director, Actuarial Science (Medicaid Rate Advocacy, Month End Close, Forecasting)
$135K - $237K *
Shape the future of actuarial science by leading innovation, guiding strategies, and enhancing financial performance through advanced modeling and regulatory compliance. Collaborate with senior leader...
Reposted 1 week ago
$93K - $120K *
Join a dynamic team as you manage clinical data throughout study lifecycles, ensuring compliance and quality. Collaborate with cross-functional teams to drive data strategy and support innovative solu...
3 weeks ago
Regulatory and Legal Operations Manager
$110K - $130K *
Optimize regulatory compliance and legal operations in healthcare. Collaborate with cross-functional teams to ensure adherence to industry standards while driving efficiency and effectiveness in legal...
Yesterday
$124K - $155K *
Champion data-driven insights as you lead a multidisciplinary analytics team, driving client performance and strategic recommendations to enhance business growth and market competitiveness...
3 days ago
Sr. Manager, Sales Performance
$102K - $141K *
Join a team that's dedicated to enhancing sales performance through strategic process development, technology alignment, and targeted training. Collaborate with cross-functional teams to drive effecti...
2 days ago
Regional OFCI Sr. Supply Chain Manager
$160K - $190K *
Transform your career with a pivotal role in supply chain management, overseeing procurement and execution of critical systems for global data center projects, ensuring quality and timely delivery whi...
3 days ago
$160K - $200K *
Shape the future of platform capabilities by leading strategy and execution for data, AI, and user experience initiatives. Collaborate with cross-functional teams to drive innovation and enhance custo...
Yesterday
$185K - $315K *
Join a team that's shaping global tax strategy and compliance. In this leadership role, you'll drive tax planning, manage risks, and collaborate with executives to support business growth in a dynamic...
2 weeks ago
Executive Director, Translational Medicine & Pediatric Planning
$246K - $332K *
Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...
2 weeks ago
Director - AI Digital Product Management - Commercial Value & Access
$199K - $269K *
Grow your career with a leadership role in AI Digital Product Management, driving strategy and innovation across a portfolio of AI products. Collaborate with cross-functional teams to deliver scalable...
3 weeks ago
EverPro: Senior Director Payments
$210K - $250K *
Transform the payments landscape by leading strategy and execution across product, engineering, and operations. Drive growth and innovation in embedded payments, ensuring alignment and measurable outc...
2 weeks ago
Area Director, Electrophysiology & Structural Heart- North
$176K - $243K *
Unlock potential by leading strategic initiatives in cardiovascular imaging, driving adoption of advanced technologies, and fostering partnerships to enhance patient care and clinical outcomes across...
Reposted yesterday
Director, Clinical Research and Cancer Center Advisory Services
$175K - $200K *
Drive impactful change in healthcare consulting by leveraging your expertise in clinical operations and research administration. Collaborate with executive leaders to solve complex challenges and fost...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.