Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$127K - $155K *

Elevate participant engagement by implementing strategic retention initiatives, analyzing clinical trial data, and collaborating with cross-functional teams to ensure data integrity and minimize dropo...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$192K - $264K *

Oversee the product development lifecycle, leading cross-functional teams to ensure timely and compliant launch of complex diagnostic products, while driving strategic decisions and resolving interdep...

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$139K - $232K *

Champion drug development by leading cross-functional teams to optimize project strategies, manage risks, and ensure timely delivery of critical milestones in a complex life sciences environment...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $110K *

Empower clinical teams to deliver high-quality, evidence-based ABA therapy. Lead and mentor professionals while collaborating across functions to enhance client care and support growth in a compassion...

Today

  •   Less than 5 years exp.  •   Healthcare

$100K - $110K *

Empower clinical teams to deliver high-quality, evidence-based ABA therapy. Lead and mentor professionals while collaborating across functions to enhance client care and support growth in a compassion...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Champion patient-centered care by leading a clinical team to enhance quality, ensure effective provider support, and drive strategic healthcare initiatives. Focus on mentoring and implementing value-b...

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$333K - $450K *

Lead the charge in innovative clinical programs, shaping strategies and executing trials from first-in-human to registration, while ensuring patient safety and compliance in a dynamic regulatory envir...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a dynamic team to drive operational excellence across multiple manufacturing sites, fostering continuous improvement strategies and Lean practices to enhance safety, quality, delivery, and produc...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$130K - $160K *

Drive operational excellence by implementing a unified continuous improvement system across sites, enhancing productivity, and fostering a culture of accountability and innovation while collaborating...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Transform clinical quality by supporting training initiatives, monitoring clinician performance, and ensuring compliance with quality standards for successful operational processes and clinician suppo...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform health information management by leading end-to-end processes, ensuring compliance, and optimizing workflows. Collaborate across departments to enhance operational performance and support or...

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$201K - $360K *

Shape the future of patient safety by leading pharmacovigilance efforts, ensuring compliance, and fostering collaboration across teams to enhance drug development and safety oversight throughout produ...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$254K - $308K *

Shape the future of Global Medical Psychiatry by leading innovative strategies for Schizophrenia. Oversee medical activities, foster key partnerships, and drive the execution of groundbreaking project...

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$303K - $370K *

Unlock your potential as you lead comprehensive care assessments and coordinate individualized plans, ensuring effective participant care in a mission-driven environment focused on value-based relatio...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $190K *

Lead the charge in optimizing and scaling student financial operations, enhancing processes through strategic partnerships and technology. Drive continuous improvement to ensure efficiency, compliance...

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Transform clinical trial operations by supporting planning, execution, and closeout activities. Collaborate with cross-functional teams, ensuring timely communication and quality oversight while takin...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive excellence in patient care by leading clinical operations, enhancing quality standards, and fostering team development. Collaborate on strategic initiatives to improve safety, efficiency, and pa...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Support our EMR and clinical applications projects by leading cross-functional teams, managing timelines, and ensuring successful implementation. Collaborate with stakeholders to enhance workflows and...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$252K - $304K *

Drive innovative biomarker research and lead cross-functional teams to enhance clinical programs. Contribute strategic insights and champion novel approaches in translational medicine, ensuring impact...

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$380K *

Elevate patient care as a Staff Physician in a thriving urgent care setting, managing mid-level providers and delivering comprehensive treatment with opportunities for advancement in medical leadershi...

Reposted yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Pioneer a transformative approach to patient care services by overseeing dental education operations, managing faculty-student interactions, and ensuring high standards in clinic efficiency while adhe...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$188K - $263K *

Empower organizational growth by serving as a strategic HR partner, blending business acumen with HR expertise to enhance team effectiveness, drive change, and support leaders in a dynamic biotech env...

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Transform the safety landscape by supporting comprehensive surveillance of neuroscience products, ensuring compliance with pharmacovigilance regulations, and contributing to critical safety documentat...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Empower a dedicated team to enhance resident health and wellness while ensuring compliance with regulations. Lead daily healthcare operations, develop personalized care plans, and foster a culture of...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $220K *

Oversee strategic physician leadership for clinical documentation initiatives, driving performance improvement and operational excellence while fostering collaboration across healthcare teams to enhan...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.