Explore $100K+ Jobs in California

Discover professional opportunities across California with Ladders. From established business centers to growing regional economies, the state offers senior-level roles in technology, healthcare, finance, entertainment, manufacturing, and more. Browse vetted job listings with salaries of $100,000 or higher and find positions that align with your experience and career goals.

California industries and career opportunities

California’s diverse economy supports leadership and specialized roles at companies of all sizes. Depending on your background, you may find opportunities in software and technology, life sciences, healthcare, financial services, clean energy, media, aerospace, and professional services. Job availability and compensation vary by role, employer, and location.

Find jobs throughout the state

Explore openings in major employment centers such as Los Angeles, San Francisco, San Diego, San Jose, Sacramento, and surrounding communities. Listings may include on-site, hybrid, and remote arrangements; review each posting for its work location and requirements.

Search with Ladders

Use Ladders to focus your search on vetted professional jobs paying $100,000 or more. Review role responsibilities, qualifications, compensation details, and workplace expectations, then apply directly to opportunities that fit your goals. Keep your profile and resume current so employers can better understand your experience.

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1,000+

Jobs in California

Average Salary in USD

Average Salary: $142,597

Sort By: Relevance

$80K - $95K *

Manage community health initiatives to enhance wellness and outcomes. Oversee program logistics, documentation, and education while fostering collaboration and compliance within a supportive environme...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $220K *

Empower innovation in clinical trials by developing strategies, overseeing operations, and cultivating partnerships. Drive excellence in research, enhance compliance, and manage a high-performing team...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Champion high-quality patient care by delivering compassionate nursing services, conducting assessments, and collaborating with an interdisciplinary team to enhance recovery outcomes in a fast-paced e...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Join us to deliver compassionate, high-quality nursing care in a dynamic labor and delivery environment. Collaborate with a multidisciplinary team to ensure optimal patient outcomes and support matern...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform patient care by delivering tailored physical therapy solutions. Collaborate with a dedicated team to enhance patient outcomes, ensuring effective treatment plans and a supportive environment...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Deliver high-quality, compassionate nursing care while collaborating with an interdisciplinary team to enhance patient outcomes. Utilize critical thinking and assessment skills in a fast-paced environ...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Join a team that's dedicated to delivering precise diagnostic results through advanced laboratory testing. You'll perform complex analyses, maintain equipment, and ensure quality control, playing a vi...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Join a dynamic team to oversee daily operations in Care Coordination, ensuring high-quality patient transitions. Lead and mentor staff, drive strategic initiatives, and collaborate with interdisciplin...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Manage administrative operations while leveraging clinical expertise to enhance patient care coordination. Drive process improvements and ensure adherence to policies in a dynamic healthcare environme...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Deliver compassionate, high-quality nursing care while collaborating with an interdisciplinary team to enhance patient outcomes. Utilize critical thinking and assessment skills in a fast-paced environ...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Join a team that's dedicated to optimizing patient care through comprehensive pharmaceutical services. Collaborate with healthcare professionals to enhance medication therapy and improve clinical outc...

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Empower patient recovery by delivering high-quality, compassionate care. Collaborate with an interdisciplinary team to assess, implement, and evaluate individualized care plans, ensuring optimal outco...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Transform lives by helping patients regain independence through tailored occupational therapy. Assess diverse needs, develop collaborative treatment plans, and educate families in a dynamic, high-volu...

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$300K - $350K *

Transform your career by leading a groundbreaking initiative that bridges technology and foreign policy. Shape strategy, build relationships, and create innovative programs while collaborating with to...

California, USRemote

Today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Join us in shaping the future of maternal and newborn health by leading innovative strategies in commodity financing and procurement. Drive impactful change at global and country levels to ensure esse...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$85K - $125K *

Elevate your career by driving sales and marketing for specialty medications. Collaborate with healthcare professionals to achieve revenue goals while managing relationships across multiple locations...

San Diego, CARemote

Today

  •   Less than 5 years exp.  •   Healthcare

$179K - $246K *

Drive your career forward by leading a dynamic team that crafts and delivers exceptional digital experiences. Oversee web content, UX design, and front-end development while ensuring quality and opera...

California, USRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$179K - $246K *

Shape the future of content strategy by guiding messaging across campaigns, mentoring writers, and aligning editorial work with business goals to drive measurable outcomes in a dynamic B2B environment...

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$179K - $246K *

Shape the future of integrated marketing campaigns by leading multidisciplinary teams, ensuring creative excellence and scientific accuracy across all channels. Drive impactful product launches while...

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$79K - $86K *

Empower a dynamic team as you lead operations, enhance guest experiences, and drive performance in a fast-paced coffee environment. Your leadership will shape a culture of excellence and growth while...

Today

  •   Less than 5 years exp.  •   Food & Beverages

$117K - $139K *

Elevate data-driven decision-making by enhancing the actuarial sandbox datamart and automating analytical processes. Collaborate with cross-functional teams to deliver reliable data solutions that sup...

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $250K *

Join a dynamic team as a sales-driven professional, leveraging pre-qualified leads to excel in residential sales. Enjoy uncapped commission potential and comprehensive training while building lasting...

Today

  •   Less than 5 years exp.  •   Technical Services

$209K - $273K *

Drive innovation by owning customer-facing products end to end, leading technical strategy, and shaping product direction. Collaborate across teams to build AI-native experiences that enhance user eng...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$115K - $125K *

Drive a vibrant EHS culture through strategic leadership and collaboration. Empower stakeholders with expert guidance, ensure compliance, and elevate safety standards across all operations in a dynami...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Transportation

$87K - $127K *

Unlock potential by managing clinical operations, fostering partnerships, and ensuring quality education experiences for nursing students. Collaborate with clinical sites to enhance student placements...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in California?question toggle

    California listings may include senior and specialized roles in technology, healthcare, finance, life sciences, entertainment, clean energy, manufacturing, and other fields. Available positions depend on current employer needs.

  • Where in California can I search for jobs?question toggle

    You can explore opportunities across the state, including major employment hubs such as Los Angeles, San Francisco, San Diego, San Jose, and Sacramento. Check each posting for its specific location and work arrangement.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review each listing for compensation information and details, since pay can vary by position and employer.

  • Can I find remote or hybrid California jobs?question toggle

    Some listings may offer remote or hybrid work, while others require on-site work. The job posting provides the employer’s location and work arrangement requirements.

  • How can I improve my California job search?question toggle

    Narrow your search by role, location, industry, and work arrangement. Keep your resume and profile updated, and carefully compare each opportunity’s qualifications and compensation details.